Cavernous Malformations of the Nervous System

by Edited by Daniele Rigamonti

• ISBN13: 9780521764278
• ISBN10: 0521764270
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-10-17
• Publisher: Cambridge University Press

Summary

Questions regarding the nature and appropriate management of cavernous malformation (CM) have clouded researchers and those faced with making clinical decisions for several decades. CMs may be seen as an incidental finding on MRI studies, or they may present with symptoms, such as seizures or intracranial hemorrhage, often causing severe neurologic deficit. Cavernous Malformations of the Nervous System provides a comprehensive and authoritative review of the current practice in diagnosis and management of these cerebrovascular disorders. Emphasis has been laid on the understanding of basic sciences with chapters committed to understanding of CCM1, 2 and 3 genes and their role in CCM biology, as well as clinical genetics. Controversial topics which continue to pose treatment challenges such as safety of anticoagulation and prophylactic management during pregnancy are also discussed. This book will be of interest to basic science researchers, neurosurgeons and vascular neurologists both in academic institutions and private practice.

Table of Contents

Preface

Basic Sciences

Pathology of cavernous malformations

Epidemiology and natural history of cavernous malformations

Familial cavernous malformations: a historical survey

Clinical and molecular genetics of cerebral cavernous malformations

Molecular biology of cerebral cavernous malformation

Cavernous malformations and radiation Eugenio Pozzati

Neuroimaging of cavernous malformations

Clinical features and medical management of cavernous malformations

Clinical Features, Imaging and Diagnostic Work-up

Hemorrhage: new and recurrent Colin

Medical management of seizures and the presurgical evaluation of medically intractable epilepsy

Therapy

The pros and cons of conservative and surgical treatment of cavernous malformations

Surgical treatment of cavernous malformations associated with epilepsy

Surgery of spinal cavernous malformations

Surgical treatment of cavernous malformations in children

Resection of cavernous malformations of the brainstem

Principles for managing cavernous malformations in eloquent locations

Radiosurgery of cavernous malformations: the Pittsburgh experience

Basic Aspects

Genetic counselling

Special problems in cavernous malformations

Index

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