Cell Biology of Trauma

by Lemasters; John J.

• ISBN13: 9780849324536
• ISBN10: 084932453X
• Format: Hardcover
• Copyright: 1995-03-06
• Publisher: CRC Press

Summary

This unique book presents an approach to viewing trauma. It examines the cellular consequences of trauma at a molecular level and provides new insights into the treatment of traumatic injury, based on cellular responses. The current of trauma research is reviewed, previously unpublished information on the topic is presented, and research directions are included.

Table of Contents

Mechanisms of Lethal Cell Injury

Models of Toxicity Screening Using Cultured Cells, R.L. Grant and D. Acosta, Jr.

Apoptosis: Cellular Signaling and Molecular Mechanisms, R.B. Evans and J.A. Cidlowski

Role of Mitochondrial Injury During Oxidative Injury to Hepatocytes: Evidence of a Mitochondrial Permeability Transition by Laser Scanning Confocal Microscopy, A.-L. Nieminen, R. Imberti, A.K. Saylor, S.A. Tesfai, B. Herman, and J.J. Lemasters

Cytoprotective Strategies

Glycine Cytoprotection and Inhibition of Nonlysosomal Calcium-Dependent Proteolysis During Anoxia Injury of Rat Hepatocytes, J.C. Nichols, R.C. Dickson, S.F. Bronk, and G.J. Gores

Di-Calciphor-Dependent Protection against Cell Death Due to Mitochondrial Failure, D.P. Jones

Role of Mitochondrial ATPase Inhibitor, IF1, in Cytoprotection During Ischemia in Slow and Fast Heart-Rate Hearts, W. Rouslin and C.W. Broge

The Discovery and Pharmacology of Tirilazad Mesylate, J.M. McCall

Ischemia/Reperfusion Injury

The Role of Neutrophils and Reactive Oxygen Metabolites in Reperfusion Injury, B.J. Zimmerman and D.N. Granger

The Inflammatory Response after Hepatic Ischemia-Reperfusion, H. Jaeschke

The pH Paradox in Reperfusion Injury to Heart Cells, J.J. Lemasters, J.M. Bond, I.S. Harper, E. Chacon. H. Ohata, B. Herman, and W.E. Cascio

Pathophysiology of Spinal Cord Injury in a Rat Model of Decompression Sickness, L. Marzella

Stress Response and Wound Healing

The Stress Response and Stress Proteins, M.E. Feder, D.A. Parsell, and S.L. Lindquist

Cross Talk between Heat Shock and Oxidative Stress Inducible Genes During Myocardial Adaptation to Ischemia, D.K. Das and N. Maulik

Alterations in Cell Cycle Control Factors and the Induction of Oxygen Regulated Proteins by Hypoxic Stress, H.C. Smith, R.L. Howell, and J.W. Ludlow

Stress Proteins in Renal Ischemia, S. Hilden

Human Keratinocyte Migration Involves Extracellular Matrix and Soluble Factors, D.T. Woodley, J.D. Chen, E. Shim, J.P. Kim, J.-C. Lapiere, and C. Peavey

Endothelial Cell Signaling During Wound Healing, L.H. Romer

Preservation of Cells and Organs

Development and Optimization of Preservation Solutions, J.H. Southard

Hypoxia, Free Radicals and Reperfusion Injury Following Cold Storage and Reperfusion of Livers for Transplantation, R.G. Thurman, W. Gao, H.D. Connor, S. Bachmann, R.T. Currin, R.P. Mason, and J.J. Lemasters

Cellular Injury Associated with Organ Cryopreservation: Chemical Toxicity and Cooling Injury, G.M. Fahy, C. da Mouta, L. Tsonev. B.S. Khirabadi, P. Mehl, and H.T. Meryman