Cellular and Molecular Targets in Allergy and Clinical Immunology: Proceedings of the 26th Symposium of the Collegium Internationale Allergologicum

by Holgate, Stephen

• ISBN13: 9780889373587
• ISBN10: 0889373582
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-06-01
• Publisher: HOGREFE & HUBER PUBLISHERS

Summary

Offers the proceedings of the 26th Symposium of the Collegium Internationale Allergologicum, held in St. Julian's, Malta, in 2006. Text aims to bridge the gap between the rapid progress made in diagnostic and therapeutic applications and the way that allergists practice medicine in the office. For clinicians.

Table of Contents

Preface: Cellular and Molecular Targets in Allergy and Clinical Immunology
Carl Prausnitz Lecture
From Wheals and Wheeze to Tolerance: Allergy quo vadis?	p. 1
Inflammatory Effector Cells
Regulation of c-Kit Expression in Human Mast Cells: Inhibition of SCF-Induced c-Kit Downregulation by STI 571 (Gleevec) in LAD 2 and HMC-1 Cells	p. 11
Costimulation of Mast Cells via Fc[epsilon]RI and Toll-Like Receptors Markedly Augments Production of Inflammatory Cytokines	p. 15
Escherichia coli Hemolysin Provokes Mast Cell Activation	p. 20
Surface Expression, Inhibitory Function and Candidate Ligand for Siglec-8 on Human Mast Cells	p. 23
Pharmacologic Regulation of Eosinophil Activation: New Therapeutic Targets	p. 27
Eosinophil Progenitors at Birth: Intimations of Future Atopy and Inflammation	p. 29
CXCR3 Ligand Production by Human Mast Cells in Response to Infection Associated Stimuli	p. 32
Molecular Mechanism of Hygiene Hypothesis	p. 36
Vascular Endothelial Growth Factor-A Is Stored in and Immunologically Released from Human Basophils	p. 38
Identification of Nitric Oxide Regulated Genes with Potential Roles in Signaling in Mast Cells	p. 43
Molecular Mechanisms for Regulation of the Human High-Affinity IgE Receptor [beta] Subunit (Fc[epsilon]RI[beta]) Gene Expression	p. 46
Integrating Control of Mast Cell Function and Allergic Responses	p. 49
Gene Expression Profiling of Human Mast Cell Lines	p. 54
In vivo Imaging of Activated Eosinophils in Inflamed Tissues	p. 58
Aspirin-Sensitive Rhinosinusitis Is Associated with Reduced E-Prostanoid 2 (EP2) Receptor Expression on Nasal Mucosal Inflammatory Cells	p. 61
Effects of Lipid Mediators on the Activation of Human Lung Fibroblasts	p. 63
Potentially Novel Mediators of Mast Cell-Sensory Nerve Interactions	p. 66
Allergens
Purification of the Natural Peanut Allergen Ara h 1	p. 70
Apples Can Drive Birch-Pollen-Allergic Patients Nuts! T-Cell Crossreactivity as a Basis for Food Allergy	p. 73
Mass Spectroscopic Analysis of Natural and Recombinant Preparations of Pollen (Birch, Grass, Olive) and House Dust Mite Allergens	p. 77
Identification of the Major Components of the Dust Mite Proteome and the Full Repertoire of Its Allergens	p. 80
Nitration of Allergens: Another Pollution Effect to Be Concerned About	p. 84
Modulation of the IgE Response by Blocking Membrane-IgE	p. 87
Artemisia and Ambrosia Hypersensitivity: Cosensitization or Corecognition? A Study Using Recombinant Weed Pollen Allergens	p. 90
Cytokine Responses in Peanut Nonallergic Adults Are Dominated by Th2-Like Responses in the Absence of Detectable Th1 Function	p. 93
Recombinant Hybrid Molecule Consisting of rPhI p 1, 2, 5, and 6: Is it the Best Combination for Grass Pollen Diagnosis in a Group of French Patients?	p. 97
Epitope Mapping and Characterization of the Binding Specificity of Monoclonal Antibodies Directed Against Allergens of Grass Group 1	p. 100
Relevance of Carbohydrate Determinants in Differentiating True Latex Allergy from Asymptomatic IgE Reactivity	p. 103
Immunoglobulin Free Light Chains in Hypersensitivity Reactions: Need for Crosslinking by Antigens	p. 106
Vacuolar Serine Proteases from Cladosporium herbarum and Alternaria alternata	p. 109
Pollen Pave Their Way: Th2 Micromilieu Generated by Pollen-Associated Lipid Mediators (PALMs)	p. 113
More Than 50% of Positive Challenges with Foods Are Associated with Late Eczematous Reactions in Atopic Dermatitis	p. 118
Immunotherapy and Pharmacotherapy
Elevated Histamine Release in Chimeric IgE/IgG1 Antigen Receptor Knock-in- Mice	p. 121
Mechanisms of Inhibition of Human Allergic Th2 Immune Responses by Regulatory T-Cells Induced by Interleukin 10-Treated Dendritic Cells and Transforming Growth Factor [beta]	p. 124
Anaphylactic and Anaphylactoid Reactions to Paclitaxel, Carboplatin, and Doxorubicin: Treatment with Rapid Desensitization	p. 128
Regulatory Natural Killer Cells Suppress Antigen-Specific T Cell Responses	p. 131
Environmental Prenatal Factors of Allergy in Lithuania	p. 134
Antibody Responses to Minor Allergen Bet v 2 During Allergen-Specific Immunotherapy in Birch Pollen-Allergic Patients	p. 138
Induction of "Regulatory" T-Cells by Cynodon dactylon-Specific Allergen Immunotherapy	p. 142
[alpha]-Melanocyte Stimulating Hormone and Fragments: Potential Therapeutic Agents in Inflammation	p. 147
Mechanisms of Immune Tolerance to High Dose Allergen Exposure in Healthy Individuals	p. 150
Clinical Improvement and Immunological Changes of Atopic Dermatitis in Patients Undergoing Subcutaneous Immunotherapy with Depigmented Polymerized House Dust Mite Allergens	p. 154
A Potent Adenosine A[subscript 2B] Receptor Antagonist Attenuates Methacholine-Induced Bronchial Hyperresponsiveness, Mucus Production, and IgE Levels in an Allergic Mouse Model	p. 156
Differential Regulation of Different TLR Responses by IL-10 Derived from Different Cell Types	p. 159
Pharmacodynamics of Latest Generation H[subscript 1]-Antihistamines; Relevance of Drug Concentrations at Receptor Sites and of Affinity Values for H[subscript 1] Receptors	p. 162
Conformational Change in the IgE-Fc[epsilon]RI Interaction as a Target for Inhibitor Design	p. 167
Protective Effects of CORM-3, a Water-Soluble Carbon-Monoxide Releasing Molecule, in a Model of Vascular Inflammation	p. 172
Insufficient T Regulatory Cell Expression and Function in Atopic Dermatitis Skin	p. 176
Hymenoptera Venom Allergy: A New Ultra-Rush Immunotherapy	p. 179
Anti-IgE Treatment Overcomes Intolerability of Honeybee-Venom Ultra-Rush Immunotherapy in Indolent Systemic Mastocytosis	p. 182
Immunomodulatory Effects of Viral Toll-Like Receptor Ligands: An Experimental Approach to the Hygiene Hypothesis	p. 184
Development of a Mucosal Polyvalent Allergy Vaccine for Primary Prevention of Multisensitization	p. 187
The Role of Advanced Glycation End Products in Asthma and Chronic Obstructive Pulmonary Disease	p. 191
Allergenicity and Immunogenicity of Commercially Available Allergoid Products for Birch Pollen Immunotherapy	p. 194
Human Antichimeric Antibodies to Infliximab and Infusion-Related Allergic Reactions in Patients with Rheumatoid Arthritis	p. 198
LAS 36674, A New Generation of H1 Antihistamines: From Bench to Bedside and Back	p. 201
Immune Effector Cells
[Beta]-Cell Development: From Bone Marrow to Peripheral Tissue in Allergy	p. 204
Parasites and Allergy: From Mice to Man	p. 208
C3a and C4a: Complement Split Products Identify Patients with Hyperacute Lyme Disease	p. 212
Plasma Cell Differentiation and Immunoglobulin Secretion Are Induced by Interleukin-4 and Anti-CD40 and Differ in Cord Blood and Adult Naive [Beta]-Cells	p. 216
Single Nucleotide Polymorphisms of CD14 Are Associated with the Development of Respiratory Syncytial Virus Bronchiolitis in Japanese Children	p. 220
CDS T-Cell - Dendritic Cell Cross-Talk	p. 223
Maternal Smoking in Pregnancy Suppresses Neonatal TLR-Mediated Microbial Responses, and This Effect Is Increased by Maternal Allergy	p. 227
The Molecular Basis of IgE-Mediated Autoreactivity	p. 237
The Stromal Microenvironment Is a Potent Regulator of Dendritic Cell Function	p. 239
Induction and Efficacy of Cytolytic Regulatory T-Cells in Experimental Asthma	p. 244
Antigen-Specific Expression of Lymphocyte Activation Markers CD69, CD25, and HLA-DR in Patients with Immediate Reactions to Amoxicillin	p. 247
Integration of Regulatory T-Cells into the Th1/Th2 Paradigm	p. 251
Association Between Epidermal Caspase- 3 Cleavage and Dermal Interferon-[gamma] Expressing Cells in Atopic Dermatitis	p. 256
Plasticity of Histamine H[subscript 1] Receptor Expression in Human Mononuclear Phagocytes	p. 259
The Role of NKT-Cells in the Development of Asthma	p. 263
Ten Years' Experience in Epidermal Dendritic Cell Phenotyping (EDCP) as a Diagnostic Tool	p. 267
Diseases of Impaired Barrier Function
Probability of Hospital Admission with Acute Asthma Exacerbation Increases with Increasing Specific IgE Antibody Levels	p. 270
IgE-Dependent Cytokine Release from Human Lung Tissue	p. 274
Detailed Sequence and Haplotype Analysis of the [beta]2 Adrenergic Receptor Gene in Caucasians and African Americans	p. 277
Atheroma - Another "Modern Disease" Explained by the Hygiene Hypothesis	p. 285
Systemic Corticosteroid Treatment Reduces Bronchial Mucosal Activation of Activator Protein-1 (AP-1) Components in Corticosteroid Sensitive, but Not Resistant Asthmatics	p. 288
Biphasic Itch Stimulus Model for Investigations Using Functional Magnetic Resonance Tomography	p. 293
Further Considerations on the Mechanisms of NSAID Hypersensitivity	p. 297
Mechanotransduction of uPA-uPAR in Airway Epithelial Cells	p. 301
Eosinophilic Esophagitis: Escalating Epidemiology?	p. 304
Interleukin-4 Regulates the Expression of Thymus- and Activation-Regulated Chemokine (TARC)/CCL17 by a Signal Transducer and Activator of Transcription 6 (STAT6)-Dependent Mechanism	p. 308
The Functional Role of Hepatocyte Growth factor in Allergic Inflammation	p. 312
Involvement of Periostin in Subepithelial Fibrosis of Bronchial Asthma Downstream of IL-4 and IL-13 Signals	p. 315
CD48 Is Critically Involved in Experimental Asthma	p. 318
Interaction of Allergic Rhinitis and Bacterial Sinusitis in a Mouse Model	p. 321
Retinol Concentrations After Birth Are Inversely Associated with Atopic Manifestations in Children and Young Adults	p. 324
Evaluation of Chronic Rhinosinusitis and the Role of Nitric Oxide Measurements	p. 327
Epigallocatechine-3-gallate Reduces Allergic Lung Inflammation in Guinea Pig Asthma-Like Reaction	p. 332
Epidemiology of the Allergic Respiratory Syndrome in Residents of Urban US Public Housing Communities	p. 336
Caspase Activation and Loss of Mitochondrial Membrane Potential Precedes Phosphatidylserine Exposure in CD45-Dependent Eosinophil Apoptosis	p. 339
Impact of IL-13 on Epidermal Inflammation in Atopic Dermatitis	p. 342
PPAR[gamma]- and Toll-Like Receptor-2 Agonists Might Have Therapeutical Value in Respiratory Syncytial Virus (RSV)-Induced Airway Disease: PPAR[gamma] Agonists May Act in a PPAR[gamma]-Independent Manner	p. 345
Author Index
Keyword Index
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