Central Nervous System Diseases

by Emerich, Dwaine F.; Dean, Reginald L.; Sanberg, Paul R.

• ISBN13: 9780896037243
• ISBN10: 089603724X
• Format: Hardcover
• Copyright: 2000-01-01
• Publisher: Humana Pr Inc

Summary

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.

Table of Contents

Preface	vii
Contributors	xiii
Part I. Aging and Alzheimer's Disease
The Cholinergic Hypothesis a Generation Later: Perspectives Gained on the Use and Integration of Animal Models	3	(44)
Raymond T. Bartus
Patterns of Cognitive Decline in the Aged Rhesus Monkey	47	(18)
Mark B. Moss
Ronald J. Killiany
James G. Herndon
Cholinergic Lesions as a Model of Alzheimer's Disease: Effects of Nerve Growth Factor	65	(16)
James M. Conner
Mark H. Tuszynski
The Immunolesioned Animal as a Model of Transmitter Dysfunction	81	(12)
Gary L. Wenk
An Intracerebral Tumor Necrosis Factor-&alfa; Infusion Model for Inflammation in Alzheimer's Disease	93	(20)
Kimberly B. Bjugstad
Gary W. Arendash
The Senescence-Accelerated Mouse as a Possible Animal Model of Senile Dementia	113	(10)
Yasuyuki Nomura
Yasunobu Okuma
Yoshihisa Kitamura
Transgenic Mice Overexpressing Presenilin cDNAs: Phenotype and Utility in the Modeling of Alzheimer's Disease	123	(8)
Karen Duff
Part II. Parkinson's Disease
Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism: Optimizing Behavioral Assessment of Outcome	131	(22)
Timothy Schallert
Jennifer L. Tillerson
Development of Behavioral Outcome Measures for Preclinical Parkinson's Research	153	(18)
Mark D. Lindner
Behavioral Assessment in the Unilateral Dopamine-Depleted Marmoset	171	(16)
L. E. Annett
R. E. Smyly
J. M. Henderson
R. M. Cummings
A. L. Kendall
S. B. Dunnett
Molecules for Neuroprotection and Regeneration in Animal Models of Parkinson's Disease	187	(22)
O. Isacson
L. C. Costantini
W. R. Galpern
Antisense Knockdown of Dopamine Receptors	209	(18)
Simranjit Kaur
Ian Creese
Is Trophic Factor Gene Disruption a ``Knockout'' Model for Parkinson's Disease?	227	(22)
Ann-Charlotte Granholm
Barry Hoffer
Part III. Huntington's Disease
Operant Analysis of Striatal Dysfunction	249	(26)
Peter J. Brasted
Mate D. Dobrossy
Dawn M. Eagle
Falguni Nathwani
Trevor W. Robbins
Stephen B. Dunnett
Intrastriatal Injections of Quinolinic Acid as a Model for Developing Neuroprotective Strategies in Huntington's Disease	275	(26)
Dwaine F. Emerich
Systemic Administration of 3-Nitropropionic Acid: A New Model of Huntington's Disease in Rat	301	(32)
Emmanuel Brouillet
Philippe Hantraye
M. Flint Beal
Replicating Huntington Disease's Phenotype in Nonhuman Primates	333	(22)
Philippe Hantraye
Stephane Palfi
Vincent Mittoux
Caroline Dautry
Francoise Conde
Emmanuel Brouillet
Transgenic Mouse Models of Huntington's Disease	355	(16)
Gillian P. Bates
Laura Mangiarini
Stephen W. Davies
Part IV. Traumatic Brain Injury and Stroke
Rigid Indentation Models of Traumatic Brain Injury in the Rat	371	(22)
Richard L. Sutton
Rodent Ischemia Models of Embolism and Ligation of the Middle Cerebral Artery: Clinical Relevance to Treatment Strategies of Stroke	393	(14)
Cesario V. Borlongan
Hitoo Nishino
Yun Wang
Paul R. Sanberg
A Primate Model of Hypertensive Cerebrovascular Disease	407	(24)
Mark B. Moss
Part V. Innovations Leading to Clinical Therapy
Nictotinic Therapeutics for Tourette Syndrome and Other Neuropsychiatric Disorders: From Laboratory to Clinic	431	(10)
R. Doug Shytle
Archie A. Silver
Mary B. Newman
Paul R. Sanberg
Neural Grafting for Parkinson's and Huntington's Disease	441	(44)
Ben Roitberg
Peter Shin
Joseph Sramek
Jeffrey H. Kordower
Future Prospects of Gene Therapy for Treating CNS Diseases	485	(24)
Daniel A. Peterson
Jasodhara Ray
Fred H. Gage
Index	509