Cerebral Vasospasm

by Seiler, R. W.; Steiger, H. j.

• ISBN13: 9783211836507
• ISBN10: 3211836500
• Format: Hardcover
• Copyright: 2001-10-01
• Publisher: Springer Verlag

Summary

Cerebral vasospasm remains a major clinical problem in patients with subarachnoid hemorrhage. Neuroprotection with calcium antagonists, hemodynamic therapy and interventional angioplasty have an established role in the management of this disease, but an effective single drug for prevention or treatment of the vasospasm is still lacking.This book contains selected contributions to the 7th International Conference on Cerebral Vasospasm held in Interlaken, Switzerland, in June 2000. Part I of the book concentrates on basic science and experimental vasospasm. The molecular biology of vasospasm, the role of endothelin and nitric oxide as well as the potential of gene therapy are presented.Part II concentrates on the diagnosis and therapy of clinical vasospasm. New diagnostic tools are presented, including diffusion and perfusion-weighted MRI, MR spectroscopy and microdialysis with metabolic monitoring. Leaders in the field discuss the current indications and results of endovascular treatment of cerebral vasospasm. The latter chapters are devoted to the treatment of clinical vasospasm with new drugs and to the prevention and treatment of ischemic deficits with neuroprotective drugs and hemodynamic therapy. The book provides the state-of-the-art in the major subjects of the molecular biology of vasoconstriction and experimental vasospasm as well as the diagnosis and treatment of clinical vasospasm.

Table of Contents

Is Cerebral Vasospasm still a Clinical Problem?	1	(4)
Seiler, R. W.
Binggeli, R.
Part 1: Basic Science and Experimental Vasospasm
Molecular Biology of Vasospasm	5	(54)
Pathophysiology and Molecular Genetics of Vasospasm	7	(6)
Macdonald, R. L.
Identification of Genes Differentially Expressed in Canine Vasospastic Cerebral Arteries after Subarachnoid Hemorrhage	13	(1)
Kasuya, H.
Onda, H.
Kawashima, A.
Sasahara, A.
Hori, T.
Complimentary Deoxyribonucleic Acid Array Analysis of Cerebral Arteries after Experimental Subarachnoid Hemorrhage	13	(8)
Zhang, Z.-D.
Marton, L. S.
Ono, S.
Komuro, T.
Weir, B.
Macdonald, R. L.
Which Protein Kinase C Isoforms are Involved in the Development of Vasospasm After Subarachnoid Haemorrhage?	21	(4)
Nishizawa, S.
Obara, K.
Nakayama, K.
Koide, M.
Yokoyama, T.
Yokota, N.
Ohta, S.
Role of Mitogen-Activated Protein Kinase in the Contractions of Rabbit Basilar Artery Induced by Hemolysate, Oxyhemoglobin, and Bloody CSF	25	(4)
Zubkov, A. Y.
Rollins, K. S.
McGehee, B.
Parent, A. D.
Zhang, J. H.
Apoptosis in Basilar Endothelial Cells in a Canine Double Hemorrhage Model	29	(4)
Zubkov, A. Y.
Tibbs, R. E.
Clower, B.
Ogihara, K.
Aoki, K.
Zhang, J. H.
Delayed Clot Removal and Experimental Vasospasm	33	(4)
Zhang, Z.-D.
Yamini, B.
Komuro, T.
Ono, S.
Johns, L.
Marton, L. S.
Weir, B.
Macdonald, R. L.
Influence of Brain Natriuretic Peptide on Phenotypic Change of Cerebral Vasculature	37	(4)
Hansen-Schwartz, J.
Sviri, G.
Edvinsson, L.
Brain Natriuretic Peptide and Cerebral Vasospasm in Subarachnoid Hemorrhage	41	(4)
Sviri, G. E.
Shik, B.
Raz, B.
Soustiel, J. F.
Phosphatidylcholine Peroxidized by Hemoglobin Increases Intracellular Calcium in Dog Basilar Artery Smooth Muscle Cells	45	(4)
Jahromi, B. S.
Komuro, T.
Macdonald, R. L.
Marton, L. S.
Weir, B. K.
Importance of Rho-Kinase-Mediated Phosphorylation of Myosin Light Chain in Vasospasm	49	(6)
Sato, M.
Tani, E.
Fujikawa, H.
Yamaura, I.
Arita, N.
Kaibuchi, K.
Role of MAPK in Chronic Cerebral Vasospasm	55	(4)
Aoki, K.
Zubkov, A. Y.
Tibbs, R. E.
Meguro, T.
Zhang, J. H.
Endothelin and Nitric Oxide	59	(22)
Endothelin: The ``Prime Suspect'' in Cerebral Vasospasm	61	(6)
Zuccarello, M.
Nitric Oxide and Vasospasm	67	(6)
Pluta, R. M.
Thompson, B. G.
Afshar, J. K.
Boock, R. J.
Iuliano, B.
Oldfield, E. H.
Effect of Endothelin-Converting Enzyme Inhibitors on Big Endothelin-1 Induced Contraction of Rabbit Basilar Artery	73	(4)
Zimmermann, M.
Jung, C.
Raabe, A.
Spanehl, O.
Seifert, V.
The Role of Endothelin I As Predictor of the Symptomatic Vasospasm in Acute Stage of Subarachnoid Hemorrhage	77	(4)
Kim, J. M.
Bak, K. H.
Kim, C. H.
Park, I. K.
Oh, S. J.
Choi, H. K.
Gene Therapy	81	(16)
Gene Therapy for Vasospasm	83	(6)
Findlay, J. M.
The Functional Significance of Heme Oxygenase-1 Gene Induction in a Rat Vasospasm Model	89	(4)
Suzuki, H.
Kanamaru, K.
Tsunoda, H.
Inada, H.
Kuroki, M.
Sun, H.
Waga, S.
Tanaka, T.
Adenovirus-Mediated Heme Oxygenase-1 Gene Transfection Prevents Hemoglobin-Induced Contraction of Rat Basilar Artery	93	(4)
Ono, S.
Komuro, T.
Macdonald, R. L.
Experimental Vasospasm	97	(22)
In Vivo Animal Models of Cerebral Vasospasm: A Review	99	(4)
Megyesi, J. F.
Findlay, J. M.
Functional Characteristics of the Spasm Model by the Polystyrene Latex Bead	103	(4)
Kang, S.
The Effect of Sympathetic Nervous System Exclusion on Cerebral Vasospasm Following Subarachnoid Hemorrhage in Rabbits	107	(4)
Bunc, G.
Kovacic, S.
Strnad, S.
Comparison of Cerebral Vasospasm Between Young and Old Animals: Preliminary Report	111	(4)
Date, I.
Nakajima, M.
Takahashi, K.
Ono, S.
Satoh, M.
Iseda, K.
Manabe, H.
Ninomiya, Y.
Asari, S.
Ohomoto, T.
Molecular Weight Interactions in Experimental Vasospasm	115	(4)
Mcdonald, R. L.
Ono, S.
Johns, L.
Marton, L. S.
Weir, B.
Zhang, Z.-D.
Yamini, B.
Komuro, T.
Ahmed, I.
Stoodley, M.
Part 2: Diagnosis and Therapy of Clinical Vasospasm
Diagnosis of Vasospasm	119	(20)
Diffusion-Weighted and Perfusion-Weighted MR of Cerebral Vasospasm	121	(6)
Lovblad, K.-O.
El-Koussy, M.
Guzman, R.
Kiefer, C.
Remonda, L.
Taleb, M.
Reinert, M.
Wels, T.
Barth, A.
Schroth, G.
Seiler, R. W.
Assessment of Cerebral Microcirculatory Changes During Cerebral Vasospasm by Analyzing Cerebral Circulation Time on DSA Images	127	(4)
Ohkuma, H.
Ogane, K.
Tanaka, M.
Suzuki, S.
Beside Monitoring of Cerebral Blood Flow in Patients with Subarachnoid Hemorrhage	131	(4)
Hegner, T.
Krayenbuhl, N.
Hefti, M.
Yonekawa, Y.
Keller, E.
Changes in Neuronal Metabolites in Brain Following Subarachnoid Haemorrhage Evaluated by Proton MR Spectroscopy	135	(4)
Handa, Y.
Kimura, H.
Arishima, H.
Ishida, M.
Ishii, H.
Kubota, T.
Microdialysis and Metabolic Monitoring	139	(20)
On-Line Microdialysis Following Aneurysmal Subarachnoid Hemorrhage	141	(4)
Sakowitz, O. W.
Sarrafzadeh, A. S.
Benndorf, G.
Lanksch, W. R.
Unterberg, A. W.
Time Course of Various Interstitial Metabolites Following Subarachnoid Hemorrhage Studied by On-Line Microdialysis	145	(4)
Sarrafzadeh, A. S.
Sakowitz, O.
Lanksch, W. R.
Unterberg, A. W.
Monitoring Subtle Neurometabolic Changes in Subarachnoid Hemorrhage Patients Using Microdialysis: A Study on 16 Cases	149	(6)
De Micheli, E.
Pinna, G.
Piovan, E.
Prisco, R.
Hillered, L.
Persson, L.
Monolo, L.
Bricolo, A.
Microdialysis Nitric Oxide Levels and Brain Tissue Oxygen Tension in Patients with Subarachnoid Hemorrhage	155	(4)
Reinert, M.
Zauner, A.
Khaldi, A.
Seiler, R.
Bullock, R.
Prevention of Vasospasm by Clot Lysis	159	(16)
Cisternal Washing Therapy for the Prevention of Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrage	161	(6)
Nakagomi, T.
Takagi, K.
Narita, K.
Nagashima, H.
Tamura, A.
Sequential Changes of Oxyhaemoglobin in Drained Fluid of Cisternal Irrigation Therapy - Reference to the Effect of Ascorbic Acid	167	(4)
Konno, Y.
Sato, T.
Suzuki, K.
Matsumoto, M.
Sasaki, T.
Kodama, N.
Cisternal Irrigation Therapy with Urokinase and Ascorbic Acid for Prevention of Vasospasm	171	(4)
Kodama, N.
Matsumoto, M.
Sasaki, T.
Konno, Y.
Sato, T.
Endovascular Treatment of Cerebral Vasospasm	175	(24)
Endovascular Treatment of Cerebral Vasospasm Following S.A.H.	177	(4)
Barreau, X.
Pastore, M.
Piotin, M.
Spelle, C.
Moret, J.
Current Indications and Results of Cerebral Angioplasty	181	(4)
Newell, D. W.
Eskridge, J. M.
Aaslid, R.
Balloon Prophylaxis of Aneurysmal Vasospasm	185	(6)
Muizelaar J. P.
Madden, L. K.
Effect of Intra-Arterial Infusion of Papaverine Hydrochloride on Brain Tissue Oxygen Pressure in the Management of Servere Vasospasm Following Aneurysmal Subarachnoid Hemorrhage	191	(4)
Reisch, R.
Filippi, R.
Bocher-Schwarz, H.
Mauer, D.
Ringel, K.
Stoeter, P.
Perneczky, A.
Long Term Follow-Up of Angioplasty for Cerebral Vasospasm	195	(4)
Srinivasan, J.
Moore, A.
Eskridge, J.
Winn, H. R.
Newell, D. W.
Treatment of Clinical Vasospasm and Neuroprotection	199	(32)
Effect of Fasudil HCI, a Protein Kinase Inhibitor, on Cerebral Vasospasm	201	(4)
Shibuya, M.
Asano, T.
Sasaki, Y.
Combined Administration of Fasudil Hydrochloride and Nitroglycerin for Treatment of Cerebral Vasospasm	205	(4)
Tanaka, Y.
Masuzawa, T.
Saito, M.
Yamada, T.
Ebihara, A.
Iwasa, H.
Mori, S.
Clinical Effect of Fasudil Hydrocloride for Cerebral Vasospasm Following Subarachnoid Hemorrhage	209	(4)
Masaoka, H.
Takasato, Y.
Nojiri, T.
Hayakawa, T.
Akimoto, H.
Yatsushige, H.
Toumori, H.
Miyazaki, Y.
Honma, M.
A Novel Drug Delivery System As Prophylaxis for Cerebral Vasospasm	213	(4)
Takanashi, Y.
Ishida, T.
Meguro, T.
Kirchmeier, M. J.
Allen, T. M.
Zhang, J. H.
Development of Nicardipine Prolonged-Release Implants for Preventing Vasospasm	217	(4)
Kasuya, H.
Kawashima, A.
Sasahara, A.
Onda, H.
Hori, T.
Inhibition of Overexpression of Endothelin-1 by an RNA Synthesis Inhibitor, Doxorubicin, in the Rat Vasospasm Model	221	(4)
Mima T.
Mostafa, M. G.
Effects of High Cervical Spinal Cord Stimulation (CSCS) on Regional Cerebral Blood Flow after Induced Subarachnoid Haemorrhage in Rats	225	(4)
Ebel, H.
Semmelmann, G.
Schomacker, K.
Balogh, A.
Volz, M.
Funke, J.
Schicha, H.
Klug, N.
Vasodilating Effect of Spinal Cord Stimulation for Cerebral Vasospasm	229	(2)
Shinonaga, M.
Takanashi, Y.
Hemodynamic Therapy and Neuroprotection	231	(36)
Metaanalysis of Trials of Tirilazad Mesylate in Aneurysmal SAH	223	(14)
Dorsch, N. W. C.
Kassell, N. F.
Sinkula, M. S.
Triple-H Therapy after Aneurysmal Subarachnoid Hemorrhage. A Review	237	(6)
Romner, B.
Reinstrup, P.
Triple-H Therapy does not Increase Cerebral Blood Flow after Induced Subarachnoid Hemorrhage in Pigs. Results of a Pilot 99mTc HMPAO-Single Photon Emission Computed Tomography Study	243	(4)
Dueck, M.
Ebel, H.
Volz, M.
Lee, J. Y.
Semmelmann, G.
Cerebral Vasospasm after Subarachnoid Hemorrhage: hypertensive Hypervolemic Hemodilution (3-H) Therapy According to New Systemic Hemodynamic Parameters	247	(4)
Krayenbuhl, N.
Hegner, T.
Yonekawa, Y.
Keller, E.
Antiischemic Therapy of Severe Prolonged Vasospasm after Aneurysmal SAH: Effects on Quality of Life	251	(4)
Kreitschmann-Andermahr, I.
Hutter, B. O.
Gilsbach, J. M.
Hypothermia Reduces Acute Vasospasm Following SAH in Rats	255	(4)
Thome, C.
Schubert, G.
Piepgras, A.
Elste, V.
Schilling, L.
Schmiedek, P.
Neuroprotective Treatment Paradigms in Neurovascular Surgery - Efficacy in a Rat Model of Focal Cerebral Ischemia	259	(8)
Zausinger, S.
Westermaier, T.
Baethmann, A.
Steiger, H. J.
Schmid-Elsaesser, R.
Author Index	267	(2)
Index of Keywords	269