Cholesterol Lowering : A Practical Guide to Therapy

by Jonathan Abrams

• ISBN13: 9780340761328
• ISBN10: 0340761326
• Format: Paperback
• Copyright: 2003-12-25
• Publisher: Hodder Arnold Publishers

Summary

Over the past decade there has been a revolution in our understanding of hypercholesterolemia and its effect on clinical coronary artery disease. While a number of controversies and unresolved issues remain, the benefit of lowering blood lipid levels and, in particular, LDL cholesterol isfirmly established. This handy practical guide takes this complex subject and puts it into context for the non-specialist. Summarizing recent clinical data, it outlines the basis for the current view that aggressive lipid lowering in selected individuals is an imperative in controlling coronaryevents. Opening with a general and broad introduction to the subject, this is followed by consideration of the biology and pathophysiology of the vascular wall, and a discussion of the basic science that underlies the impact of elevated LDL cholesterol on the function and patho-anatomy of thecoronary arteries. Subsequent chapters review practical aspects of lipid management such as what to measure and when, patient selection and the role of diet and lifestyle in disease progression. Presented in a compact format for ease of reference, the general physician, general or officepractitioner, trainee doctor and cardiac nurse specialist will find this an invaluable guide to be reached for frequently in the busy clinical setting.

Table of Contents

List of contributors	v
Foreword	vii
Antonio M Gotto, Jr
Preface	ix
Current rationale for lipid lowering	1	(19)
Jonathan Abrams
Lipids and atherosclerosis	20	(16)
Bradford C Berk
Daniel A Wuthrich
Physiology and pathophysiology of lipid metabolism	36	(16)
Robert H Knopp
Secondary causes of hyperlipidemia	52	(14)
Sylvia Vela
What to measure and when	66	(25)
Ernst J Schaefer
Leo J Seman
Judith R McNamara
Who to treat?	91	(17)
Sanjeev Puri
Jerome D Cohen
Role of diet and lifestyle	108	(21)
Neil J Stone
Drug treatment of dyslipoproteinemia	129	(18)
Donald B Hunninghake
Costs of lipid-lowering therapy with statins	147	(10)
Michael D Klein
Practical issues in implementation of lipid management	157	(14)
Merle Myerson
Report of the Adult Treatment Panel III (ATP III)	171	(6)
Richard C Pasternak
Index	177