Cholesterol Regulation of Ion Channels and Receptors

by Levitan, Irena; Barrantes, Francisco

• ISBN13: 9780470874325
• ISBN10: 0470874325
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-07-31
• Publisher: Wiley

Summary

This book brings together the most up-to-date knowledge about the role of cholesterol in regulation of ion channels and receptors and the pathological implications of these effects. It provides a comprehensive critical overview of the field comprised of three sections focusing on the impact of cholesterol on membrane structure, cholesterol regulation of ion channels and cholesterol regulation of receptors. This resource stands as a primary source of information for researchers both in academia and industrial drug development alike.

Author Biography

IRENA LEVITAN, PhD, is Associate Professor of Medicine at the University of Illinois College of Medicine at Chicago. Her research interests focus on the impact of dyslipidemia on K+ channels and endothelial biomechanics.

FRANCISCO J. BARRANTES is the former head of the National Research Council (CONICET) – Bahia Blanca and UNESCO Chair of Biophysics and Molecular Neurobiology. Currently, he is Director of the Laboratory of Molecular Neurobiology and Professor at the Faculty of Medical Sciences, Pontifical Catholic University of Argentina. His current research interests focus on the understanding of nicotinic acetylcholine receptor-membrane cross-talk.

Table of Contents

Preface

Foreword

Contributors

Cholesterol Regulation of Membrane Properties

Cholesterol trafficking and distribution between cellular membranes

Cholesterol regulation of membrane protein function by changes in bilayer physical properties - an energetic perspective

Cholesterol Regulation of Ion Channels

Insights into structural determinants of cholesterol sensitivity of Kir channels

Role for lipid rafts in the regulation of store-operated Ca2+ channels

Cholesterol regulation of cardiac ion channels

Differential contribution of BK subunits to nongenomic regulation of channel function by steroids

Regulation of K+ channels by cholesterol-rich membrane domains in immune system

Indirect channel regulation by cholesterol: The role of caveolae and caveolins in regulating KATP channel function

Cholesterol Regulation of Receptors

Regulation of the nicotinic acetylcholine receptor by cholesterol as a boundary lipid

Specific and non-specific regulation of GPCR function by cholesterol

Structural insights into cholesterol interactions with G protein-coupled receptors

Membrane cholesterol: Implications in receptor function

The role of cholesterol and lipid rafts in regulation of TLR receptors

Index

Table of Contents provided by Publisher. All Rights Reserved.