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Clinical Chemistry : Principles, Procedures, Correlations,9780781717762
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Clinical Chemistry : Principles, Procedures, Correlations

by
ISBN13:

9780781717762

ISBN10:
0781717760
Format:
Hardcover
Pub. Date:
11/1/1999
Publisher(s):
Lippincott Williams & Wilkins
List Price: $66.95
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Summary

Organon Teknika Corporation, Durham, NC. Textbook Brandon/Hill Allied Health List selection (#30). Completely revised text incorporates recent technologies, techniques, and opportunities. Balances analytical principles and techniques and the correlation of laboratory results. For students. Two-tone highlighting. Previous edition: c1996. DNLM: Chemistry, Clinical.

Table of Contents

Part 1 Basic Principles and Practice of Clinical Chemistry
Basic Principles and Practice of Clinical Chemistry
Eileen Carreiro-Lewandowski
Units of Measure
2(1)
Temperature
3(1)
Reagent Preparation
3(3)
Clinical Laboratory Supplies
6(8)
Basic Separation Techniques
14(1)
Laboratory Mathematics and Calculations
15(7)
Specimen Considerations
22(4)
Summary
26(1)
Exercises
26(1)
References
27(1)
Laboratory Safety and Regulations
Carolyn Houghton
Mary Ruth Beckham
Laboratory Safety and Regulations
28(1)
Safety Awareness for Clinical Laboratory Personnel
29(1)
Safety Equipment
30(2)
Biologic Safety
32(1)
Chemical Safety
32(2)
Radiation Safety
34(1)
Fire Safety
35(1)
Control of Other Hazards
35(2)
Disposal of Hazardous Materials
37(1)
Accident Documentation and Investigation
38(1)
Summary
38(1)
Review Questions
38(1)
Suggested Readings
39(1)
Quality Control and Statistics
George S. Cembrowski
Anne M. Sullivan
Tammy L. Hofer
Statistical Concepts
40(7)
Reference Intervals (Normal Range)
47(4)
Diagnostic Efficacy
51(2)
Method Selection and Evaluation
53(5)
Quality Assurance and Quality Control
58(13)
Practice Problems
71(2)
Review Questions
73(1)
References
74(3)
Analytical Techniques and Instrumentation
Alan H. B. Wu
Spectrophotometry and Photometry
77(11)
Electrochemistry
88(3)
Electrophoresis
91(3)
Chromatography
94(6)
Osmometry
100(1)
Analytical Techniques for POCT
101(1)
Summary
101(1)
Exercises
102(1)
References
103(2)
Immunoassays and Nucleic Acid Probe Techniques
Catherine Sheehan
Immunoassays
105(13)
Nucleic Acid Probes
118(3)
Summary
121(1)
Review Questions
121(1)
References
122(2)
Principles of Clinical Chemistry Automation
Larry Schoeff
History of Automated Analyzers
124(1)
Driving Forces Toward More Automation
125(1)
Basic Approaches to Automation
125(1)
Steps in Automated Analysis
126(11)
Selection of Automated Analyzers
137(1)
Total Laboratory Automation
137(2)
Future Trends in Automation
139(1)
Summary
140(1)
Review Questions
140(1)
References
140(2)
Point-of-Care Testing
Steve Bradley
Point-of-Care Testing (POCT)
142(1)
Use and Applications for POCT
142(2)
Implementation and Monitoring of POCT
144(3)
Cost Issues
147(1)
Regulatory Issues
148(1)
Summary
148(1)
Review Questions
149(1)
References
149(3)
Part 2 Clinical Correlations and Analytical Procedures
Amino Acids and Proteins
Barbara J. Lindsey
Amino Acids
152(6)
Proteins
158(24)
Summary
182(1)
Review Questions
182(1)
References
183(2)
Enzymes
Robin Gaynor Krefetz
General Properties and Definitions
185(1)
Enzyme Classification and Nomenclature
186(1)
Enzyme Kinetics
186(6)
Enzymes of Clinical Significance
192(16)
Pathophysiologic Conditions
208(4)
Summary
212(1)
Review Questions
213(1)
References
213(1)
Suggested Readings
214(1)
Carbohydrates
Vicki S. Freeman
General Description of Carbohydrates
215(5)
Hyperglycemia
220(4)
Hypoglycemia
224(2)
Role of Laboratory in Differential Diagnosis and Management of Patients With Glucose Metabolic Alterations
226(4)
Summary
230(1)
Review Questions
230(1)
References
231(2)
Lipids and Lipoproteins
Judith R. McNamara
G. Russell Warnick
Lily L. Wu
Lipid Chemistry
233(4)
Lipoprotein Physiology and Metabolism
237(4)
Lipid and Lipoprotein Analyses
241(7)
Lipid and Lipoprotein Distribution in the Population
248(2)
Disease Prevention, Diagnosis, and Treatment
250(4)
Summary
254(1)
References
255(6)
Nonprotein Nitrogen
Dennis W. Jay
Urea
261(2)
Creatinine/Creatine
263(4)
Uric Acid
267(3)
Ammonia
270(2)
Summary
272(1)
Review Questions
272(1)
References
273(2)
Porphyrins and Hemoglobin
Louann W. Lawrence
Porphyrins
275(5)
Hemoglobin
280(11)
Myoglobin
291(1)
Summary
291(1)
Review Questions
292(1)
References
293(1)
Electrolytes
Joan E. Polancic
Water
294(3)
The Electrolytes
297(21)
Anion Gap
318(1)
Electrolytes and Renal Function
318(2)
Summary
320(1)
Review Questions
320(1)
References
320(2)
Trace Elements
Susan A. Hurgunow
Iron
322(4)
Copper
326(2)
Zinc
328(1)
Cobalt
328(1)
Chromium
328(1)
Fluorine
328(1)
Manganese
329(1)
Molybdenum
329(1)
Selenium
329(1)
General Considerations in Laboratory Determinations of Trace Elements
330(1)
Summary
330(1)
Review Questions
330(1)
References
331(4)
Blood Gases, pH, and Buffer System
Sharon S. Ehrmeyer
Kevin D. Fallon
Definitions: Acid, Base, Buffer
335(1)
Acid-Base Balance
335(3)
Assessment of Acid-Base Homeostasis
338(2)
Oxygen and Gas Exchange
340(4)
Measurement
344(3)
Quality Assurance
347(3)
Summary
350(1)
Review Questions
350(1)
References
350(4)
Part 3 Assessment of Organ System Functions
Liver Function
Edward P. Fody
Anatomy
354(1)
Physiology
354(4)
Disorders of the Liver
358(1)
Assessment of Liver Function
359(9)
Summary
368(1)
Review Questions
368(1)
References
369(4)
Endocrinology
Shauna C. Anderson
Hormones
373(2)
Methodologies
375(3)
Components of the Endocrine System
378(20)
Summary
398(1)
Review Questions
399(2)
References
401(2)
Thyroid Function
H. Jesse Guiles
Thyroid Anatomy and Physiology
403(1)
Biosynthesis, Secretion, Transport, and Action of Thyroid Hormones
404(1)
Regulation of Thyroid Hormones
405(1)
Assays for Thyroid Function
406(3)
TSH
409(4)
Thyroid Disorders and Correlation of Laboratory Data
413(7)
Summary
420(1)
Review Questions
420(1)
References
420(3)
Cardiac Function
Lynn Ingram
The Heart
423(2)
Symptoms of Heart Disease
425(1)
Congenital Heart Disease
425(2)
Congestive Heart Failure
427(2)
Coronary Heart Disease
429(1)
Hypertensive Heart Disease
430(1)
Infective Heart Disease
431(1)
Diagnosis of Heart Disease
432(4)
Treatment
436(2)
Summary
438(1)
Review Questions
438(1)
References
439(1)
Renal Function
Carol J. Skarzynski
Alan H. B. Wu
Renal Anatomy
440(1)
Renal Physiology
441(6)
Analytical Procedures
447(6)
Pathophysiology
453(8)
Summary
461(1)
Review Questions
462(1)
References
462(1)
Pancreatic Function
Edward P. Fody
Physiology of Pancreatic Function
463(1)
Diseases of the Pancreas
464(2)
Tests of Pancreatic Function
466(3)
Summary
469(1)
Review Questions
469(1)
References
470(1)
Suggested Readings
470(1)
Gastrointestinal Function
Edward P. Fody
Physiology and Biochemistry of Gastric Secretion
471(1)
Clinical Aspects of Gastric Analysis
471(1)
Tests of Gastric Function
472(1)
Intestinal Physiology
472(1)
Clinicopathologic Aspects of Intestinal Function
473(1)
Tests of Intestinal Function
473(2)
Summary
475(1)
Review Questions
475(1)
References
476(1)
Suggested Readings
476(1)
Body Fluid Analysis
Frank A. Sedor
Amniotic Fluid
477(5)
Cerebrospinal Fluid
482(3)
Sweat
485(1)
Synovial Fluid
486(1)
Serous Fluids
486(1)
Summary
487(1)
Review Questions
488(1)
References
489(1)
Suggested Readings
489(3)
Part 4 Specialty Areas of Clinical Chemistry
Therapeutic Drug Monitoring
David P. Thorne
Routes of Administration
492(1)
Absorption
492(1)
Free Versus Bound Drugs
493(1)
Drug Distribution
493(1)
Drug Elimination
493(2)
Pharmacokinetics
495(2)
Sample Collection
497(1)
Cardioactive Drugs
497(2)
Antibiotics
499(1)
Antiepileptic Drugs
500(1)
Psychoactive Drugs
501(1)
Bronchodilators
502(1)
Immunosuppressive Drugs
502(1)
Antineoplastics
503(1)
Summary
503(1)
Review Questions
504(1)
References
505(1)
Suggested Readings
505(1)
Toxicology
David P. Thorne
Exposure to Toxins
506(1)
Routes of Exposure
507(1)
Dose Response Relationship
507(1)
Analysis of Toxic Agents
508(1)
Toxicology of Specific Agents
508(7)
Toxicology of Therapeutic Drugs
515(1)
Toxicology of Drugs of Abuse
516(3)
Summary
519(1)
Review Questions
519(1)
References
520(1)
Suggested Readings
521(2)
Tumor Markers
Anthony W. Butch
Nicole A. Massoll
Alex A. Pappas
Classification of Tumor Markers
523(1)
Tumor Markers in Cancer Management
523(26)
Properties of an Ideal Tumor Marker
549
Oncofetal Antigens
524(6)
Placental Proteins
530(1)
Enzymes and Isoenzymes as Tumor Markers
531(1)
Hormones
532(1)
Steroid Receptors
533(1)
Immunophenotyping
534(1)
DNA Analyses
534(2)
Summary and Future Developments
536(1)
Review Questions
536(1)
References
537(3)
Vitamins and Nutritional Assessment
A. Michael Spiekerman
Vitamins
540(14)
Nutritional Assessment
554(12)
Summary
566(1)
Review Questions
567(1)
References
568(4)
Clinical Chemistry and the Geriatric Patient
Janet L. Duben-Engelkirk
Sharon M. Miller
The Impact of Geriatric Patients on the Clinical Laboratory
572(1)
Theories of Aging
573(1)
Biochemical and Physiological Changes of Aging
574(4)
Clinical Chemistry Results and Aging
578(3)
Summary
581(1)
Review Questions
581(1)
References
581(2)
Pediatric Clinical Chemistry
John E. Sherwin
Juan R. Sobenes
Age Related Development Changes
583(1)
Phlebotomy and Microchemistry for the Pediatric Patient
584(1)
Acid Base Balance in the Infant
584(1)
Electrolyte and Water Balance
585(3)
Energy Metabolism
588(6)
Developmental Changes in Hormone Balance
594(4)
Drug Therapy and Pharmacokinetics
598(1)
Inborn Errors of Metabolism
598(3)
Humoral and Cellular Immunity
601(6)
Summary
607(1)
Review Questions
607(1)
References
608(1)
Appendices 609(18)
A. Selected Laboratory Abbreviations
610(1)
B. Basic SI Units
611(1)
C. Prefixes to be Used with SI Units
611(1)
D. Basic Clinical Laboratory Conversions
611(1)
E. Conversion of Traditional Units to SI Units for Common Chemistry Analytes
612(1)
F. Greek Alphabet Table
613(1)
G. Concentrations of Commonly Used Acids and Bases with Related Formulas
613(1)
H. Examples of Incompatible Chemicals
614(1)
I. Nomogram for the Determination of Body Surface Area
615(1)
J. Relative Centrifugal Force Nomograph
616(1)
K. Centrifugation---Speed and Time Adjustment
617(1)
L. Percent Transmittance--Absorbance Conversion Table
617(1)
M. Selected Atomic Weights
618(1)
N. Selected Radioactive Elements
619(1)
O. Characteristics of Types of Glass
619(1)
P. Characteristics of Types of Plastic
620(1)
Q. Chemical Resistance of Types of Plastic
620(1)
R. Cleaning Labware
621(1)
S. Summary Table of Pharmacokinetic Parameters
622(2)
T. Selected Information on Commonly Abused Drugs
624(2)
U. Periodic Chart of the Elements
626(1)
Glossary 627(12)
Answers to Review Questions, Exercises, Practice Problems, and Case Studies 639(22)
Index 661


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