Complete Accounts of Integrated Drug Discovery and Development Recent Examples from the Pharmaceutical Industry, Volume 2

by Pesti, Jaan. A; Abdel-Magid, Ahmed F.; Vaidyanathan, Rajappa

• ISBN13: 9780841234321
• ISBN10: 0841234329
• Format: Hardcover
• Copyright: 2020-10-09
• Publisher: American Chemical Society

Author Biography

Jaan A. Pesti, EnginZyme AB, Stockholm, Sweden

Ahmed F. Abdel-Magid, Therachem Research Medilab, LLC, Chelsea, Alabama, United States

Rajappa Vaidyanathan, Bristol-Myers Squibb, Bangalore, India

Table of Contents

Preface

Chapter 1. Synthetic Routes for Venetoclax at Different Stages of Development Yi-Yin Ku and Michael D. Wendt

Chapter 2. Discovery and Development of Lorlatinib: A Macrocyclic Inhibitor of EML4-ALK for the Treatment of NSCLC Robert Dugger, Bryan Li, and Paul Richardson

Chapter 3. From Discovery to Market Readiness: The Research and Development of the B-Sparing Phosphatidylinositol 3-Kinase Inhibitor Taselisib Remy Angelaud, Steve Staben, Timothy Heffron, Andreas Schuster, and Frederic St-Jean

Chapter 4. Discovery and Development of the First Antibody-Antibiotic Conjugate Linker-Drug Stefan G. Koenig and Thomas H. Pillow

Chapter 5. The Discovery of the Nav1.7 Inhibitor GDC-0276 and Development of an Efficient Large-Scale Synthesis Andreas Stumpf, Daniel Sutherlin, Christoph M. Dehnhardt, and Remy Angelaud

Chapter 6. Discovery and Development of AMG 333: A TRPM8 Antagonist for Migraine Neil F. Langille and Daniel B. Horne

Chapter 7. The Discovery and Chemical Development of PF-06273340: A Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor for Pain David C. Blakemore, Thomas Brandt, Craig Knight, and Sarah E. Skerratt

Chapter 8. Optimization of an Azaindazole Series of CCR1 Antagonists and Development of a Semicontinuous-Flow Synthesis Christian Harcken, Joshuaine Grant, Hossein Razavi, Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, and Jonathan T. Reeves

Chapter 9. Discovery and Development of Non-Covalent, Reversible Bruton's Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853) James J. Crawford and Haiming Zhang

Chapter 10. Discovery and Early Development of Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors David W. Piotrowski and Emma L. McInturff

Chapter 11. Rational Design to Large-Scale Synthesis: Development of GSK8175 for the Treatment of Hepatitis C Virus Infection Andrew J. Peat and Shiping Xie

Editors' Biographies
Author Index
Subject Index