Contemporary Issues in Modeling Psychopathology

by Myslobodsky, Michael S.; Weiner, Ina

• ISBN13: 9780792379423
• ISBN10: 079237942X
• Format: Hardcover
• Copyright: 2000-09-01
• Publisher: Kluwer Academic Pub

Summary

Despite considerable progress in clinical and basic neurosciences, the cure of psychiatric disorders is still remote, little is known about their prevention, and the etiology and molecular mechanisms of mental disorders are still obscure. Diagnoses are still guided by patients' stories. The mission of animal models is to bridge the gap between 'the story and the synapse.' Contemporary Issues in Modeling of Psychopathology attempts to do this by examining such questions as 'What good might come from such a model? Are we wasting our time? How far can we carry results from model animals, such as rats and mice, without causing a highly distorted view of the field and its goals?' This book serves as the opening volume for a new series, Neurobiological Foundation of Aberrant Behaviors .

Table of Contents

Involvement of Dopamine Transporters in Psychiatric Disorders	1	(18)
Gary W. Miller
Raul R. Gainetdinov
Marc G. Caron
The Long-Term Behavioral and Neurobiological Consequences of Treatment with Psychomotor Stimulant Drugs: Implications for Psychopathology	19	(10)
Terry E. Robinson
Anxiety and Impulse Control in Rats Selectively Bred for Seizure Susceptibility	29	(16)
Dan C. McIntyre
Hymie Anisman
Behavioral and Neurohormonal Sequelae of Prenatal Strees: a Suggested Model of Depression	45	(10)
Marta Weinstock
promises and Limitations of Transgenic and Knockout Mice in Modeling Psychiatric Symptoms	55	(24)
Andrew Holmes
Jacqueline N. Crawley
Viral Mechanisms of Schizophrenia	79	(24)
Bradley D. Pearce
Prepulse Inhibition as a Cross-Species Model of Sensorimotor Gating Deficits in Schizophrenia	103	(10)
Mark A. Geyer
Neural Systems Involved in Fear Inhibition: Extinction and Conditioned Inhibition	113	(30)
Michael Davis
William A. Falls
Jonathan Gewirtz
Brain laterality as a Source of Individual Differences in Behavior: Animal Models of Depression and Substance Abuse	143	(22)
Jeffrey N. Carlson
Isabelle M. maisonneuve
Stanley D. Glick
Animal Models of Bipolar Disorder: From a Single Episode to progressive Cycling Models	165	(16)
Haim Einat
Ora Kofman
Robert H. Belmaker
Emergence of PTSD-type Reactivity in Sprague-Dawley Rats Following Prenatal Gamma Irradiation	181	(16)
Matti Mintz
Michael Myslobodsky
The Latent inhibition model of Schizophrenia	197	(34)
Ina Weiner
Rat Latent Inhibition and Prepulse Inhibition are Sensitive to Different Manipulations of the Social Environment: a Comprehensive Study of the Environmental Approach to Neurodevelopmental Models of Schizophrenia	231	(16)
Joram Feldon
Julia Lehmann
Christopher Pryce
Isabelle Weiss
Animal Models of Set-Formation and Set-Shifting Deficits in Schizophrenia	247	(12)
Trevor W. Robbins
Early Disruption of Corticolimbic Circuitry as a Model of Schizophrenia	259	(16)
Barbara K. Lipska
Daniel R. Weinberger
Coping with Uncertainty: What would an Animal Model of Schizophrenia Look Like?	275	(18)
Loring J. Ingraham
Michael Myslobodsky
Models of Psychoses: Which One, When, and Why?	293	(20)
Michael Myslobodsky
Ina Weiner
Index	313