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Dr. Neal R. Cutler, Founder and Chairman of Worldwide Clinical Trials, Inc. Previous positions include Deputy Clinical Director of the National Institute on Aging, and Chief, Section on Brain Aging and Dementia. He is currently President of the American Foundation for Clinical Pharmacology.
Dr. John J. Sramek, Director of Clinical Research at Alamo Pharmaceuticals.
Dr Michael F. Murphy, Chief Medical and Scientific Officer, Worldwide Clinical Trials, Inc.
Dr Henry J. Riordan, Senior Vice President, Medical and Scientific Affairs, Worldwide Clinical Trials, Inc.
Dr Peter Biek, Department of Clinical Research, Worldwide Clinical Trials
Dr Angelico Carta, Cedra Clinical Research LLC
Acknowledgments | p. vi |
Foreword | p. vii |
The impending crisis in CNS drug development | p. 1 |
Animal models and procedures for CNS disorders | p. 14 |
Preclinical antecedents to early human clinical trials | p. 70 |
Biomarkers and surrogate markers in drug development | p. 101 |
Neuroimaging and cognitive assessments in early drug development | p. 167 |
Bridging and CSF studies | p. 187 |
A case study from preclinical to early clinical trials | p. 230 |
Index | p. 254 |
Table of Contents provided by Ingram. All Rights Reserved. |
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