Dedication | p. v |
Acknowledgments | p. xiii |
About the Editors | p. xv |
Contributing Authors | p. xix |
Preface | p. xxiii |
Foreword | p. xxv |
I Recently Did a Colonoscopy on a Patient With Rectal Bleeding. The Patient Had Inflammation in the Rectosigmoid and Also in the Cecal Area. Is This Crohn's Disease? | p. 1 |
When Is it Appropriate to Switch to Another Biologic Therapy? | p. 5 |
Is There Ever a Time to Switch 5-Aminosalicyclic Acids in Ulcerative Colitis? | p. 11 |
When and How Do You Use Aminosalicylates in Crohn's Disease? How Do You Monitor Response to Therapy With These Agents? | p. 13 |
What Is the Role of Concomitant Immunomodulators With Biologic Use in Inflammatory Bowel Disease? | p. 15 |
What New Drugs Have Recently Been Released to Treat Inflammatory Bowel Disease? What New Drugs Can We Anticipate Being Released in the Next 5 Years? How Will They Change Our Treatment Algorithms? | p. 21 |
What Are the Risks of Biologic Therapies, and How Do You Communicate This to Patients? | p. 27 |
Should I Measure Thiopurine Methyltransferase Genotype or Enzyme Activity Before Starting a Patient on Azathioprine or 6-Mercaptopurine? | p. 33 |
How do You Monitor Patients on Azathioprine/6-Mercaptopurine? | p. 39 |
How Long Do You Wait Before Declaring Treatment Failure With Azathiprine/6-Mercaptopurine, and Do You Ever Consider Stopping Therapy With These Agents After a Period of Time? | p. 45 |
My Partner Uses Methotrexate as His First Line Agent in Crohn's Disease. How Do You Choose Between 6-Mercaptopurine and Methotrexate? | p. 47 |
If I Want to Use Methotrexate for My Patients With Crohn's Disease, What Dose(s) and What Route of Administration (Subcutaneous, Intramuscular, or Oral) Should I Use? Is There a Risk of Hepatotoxicity or Pulmonary Toxicity? | p. 49 |
Which Patients Might Be Better for a "Top-Down" Approach (Using Anti-Tumor Necrosis Factor Therapy Before Steroids or Proven Failure of Oral Thiopurines)? What Clinical Behavior or Serological Markers Might You Use to Identify These Patients? | p. 51 |
How Do You Approach Polypoid Lesions in Patient With Inflammatory Bowel Disease? | p. 57 |
Should I Be Using Chromoendoscopy in My Surveillance Colonoscopy in Inflammatory Bowel Disease? How and Which Agent? Would Narrow Band Imaging Be an Alternative for This? | p. 63 |
Can We Follow Flat Low-Grade Dysplasia? Is Any Dysplasia Really Flat or Just a Spectrum of Depth and Size? | p. 67 |
Can Medications Like Folic Acid, Ursodeoxycholic Acid, or 5-Aminosalicyclic Acids Lower the Risk of Colorectal Cancer or Dysplasia in Patients With Inflammatory Bowel Disease? | p. 71 |
Which of My Inflammatory Bowel Disease Patients Should I Screen for Osteoporosis? Should I Also Screen for Vitamin D Deficiency? | p. 75 |
How Do You Screen and Survey for Dysplasia in Crohn's Patients? Can You Perform Segmental Resection in Crohn's Patients With Dysplasia? | p. 79 |
What Should We Be Telling Our Patients and Their Pediatricians About Using Anti-Tumor Necrosis Factor Alpha Therapy During Pregnancy? | p. 83 |
What Are the Risks to the Fetus and to the Baby Regarding Azathioprine and 6-Mercaptopurine in Pregnancy and Nursing? | p. 87 |
My 25-Year-Old Patient With Crohn's Disease on Azathioprine Was Recently Diagnosed With HPV. Is it Safe to Continue the Azathioprine? | p. 91 |
What Is the Role of Computed Tomographic Enterography in the Diagnosis and Management of Inflammatory Bowel Disease? Has it Replaced Barium Radiography? | p. 93 |
I Recently Did a Capsule Endoscopy on a Young Patient With Diarrhea. The Colonoscopy, Endoscopy, and Biopsies Were All Normal, but the Capsule Showed Several Erosions Scattered Throughout the Small Bowel. Is This Crohn's Disease? | p. 97 |
How Do You Diagnose Pouchitis? | p. 101 |
How Do You Treat Pouchitis? | p. 105 |
My Partner Tells Me That "Serology 7" Profiles Can Predict Which Crohn's Disease Patients Will Progress Rapidly. Should I Order This for All of My Newly Diagnosed Crohn's Disease Patients? Are There Additional Clinical or Genetic Factors That Identify a High-Risk Group? | p. 109 |
Do Any Medications Slow the Progression of Primary Sclerosing Cholangitis? | p. 113 |
What Is the Best Approach to Dosing Cyclosporine for Severe Ulcerative Colitis? Can Infliximab Be Used Before Cyclosporine Dosing? Can Cyclosporine Be Used Before Infliximab? | p. 117 |
When Should Bowel Rest or Elemental Feeding Be Used in the Management of Crohn's Disease? | p. 121 |
How Do You Treat Microscopic Colitis? | p. 127 |
Should I Dilate Colonic Strictures in Patients With Crohn's Disease? | p. 131 |
Is There a Role for Measuring C-Reactive Protein, Erythrocyte Sedimentation Rate, or Fecal Calprotectin in My Inflammatory Bowel Disease Patients? | p. 135 |
What Is the Definition of Corticosteroid Dependence? How Do I Treat Patients With Corticosteroid-Dependent Inflammatory Bowel Disease? | p. 139 |
How Can I Clarify the Diagnosis in My Patient With Indeterminate Colitis? | p. 143 |
How Should I Treat My Crohn's Patient Postoperatively? | p. 147 |
Is it Safe and Effective to Vaccinate My Patient With Inflammatory Bowel Disease? | p. 151 |
What Is the Risk of Developing Lymphoma in My Patients With Crohn's Disease, and Do the Immunomodulators and Biologic Agents Increase the Risk? | p. 157 |
How Do You Dose 5-Aminosalicyclic Acids? When Do You Use Topical Therapy? How Do You Monitor During Therapy? | p. 161 |
Do Probiotics Have a Role in Treating Inflammatory Bowel Disease Patients? | p. 165 |
What Is Your First Line Approach to the Diagnosis and Treatment of Patients With Perianal Crohn's Disease? | p. 169 |
How Do You Handle an Inflammatory Bowel Disease Patient With Clostridium Difficile Infection? | p. 173 |
How Do You Manage Moderate to Severe Duodenal Crohn's Disease? | p. 177 |
What Is the Necessary Testing That Should Be Performed Before Initiating Biologic Therapy? | p. 181 |
How Do You Manage Pyoderma Gangrenosum in the Setting of Inflammatory Bowel Disease? | p. 185 |
My 25-Year-Old Patient Has Diffuse Arthralgias. Can He Take Non-Steroidal Anti-Inflammatory Drugs? | p. 189 |
My Patient Has a History of Breast Cancer and Is in Remission From That Condition. She Also Has Crohn's Disease. Can I Use Azathioprine or Infliximab to Treat Her? | p. 193 |
I Have a Patient Whose Brother Has Crohn's Disease. Is There Anything I Should Tell Him to Prevent Disease Onset or to Diagnose the Disease Sooner? | p. 197 |
Is the Diagnosis, Treatment, and Response to Treatment Different in Nonwhites? | p. 201 |
Index | p. 205 |
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