Cyclic Nucleotide Phosphodiesterases in Health and Disease

by Beavo; Joseph A.

• ISBN13: 9780849396687
• ISBN10: 0849396689
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-12-05
• Publisher: CRC Press

Summary

Since the last major compendium on the topic was published over 15 years ago, substantial progress has led to a vastly improved understanding of cyclic nucleotide phosphodiesterases (PDEs). Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. With contributions from pioneers in the field, this book collates current information concerning the fundamental biochemical features of each known PDE family, their structure and genetics, and their involvement in signaling, physiology, and disease processes. It points toward future directions of research and advancements in developing therapeutic selective inhibitors for these various enzymes.

Table of Contents

Introduction
Cyclic Nucleotide Phosphodiesterase Superfamily	3	(16)
Joseph A. Beavo
Miles D. Houslay
Sharron H. Francis
Phosphodiesterase Isoforms---An Annotated List	19	(16)
Graeme B. Bolger
Section A Specific Phosphodiesterase Families---Regulation, Molecular and Biochemical Characteristics
Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases	35	(20)
Andrew T. Bender
PDE2 Structure and Functions	55	(24)
Sergio E. Martinez
Phosphodiesterase 3B: An Important Regulator of Energy Homeostasis	79	(20)
Eva Degerman
Vincent Manganiello
Cellular Functions of PDE4 Enzymes	99	(32)
Graeme B. Bolger
Marco Conti
Miles D. Houslay
Phosphodiesterase 5: Molecular Characteristics Relating to Structure, Function, and Regulation	131	(34)
Sharron H. Francis
Roya Zoraghi
Jun Kotera
Hengming Ke
Emmanuel P. Bessay
Mitsi A. Blount
Jackie D. Corbin
Photoreceptor Phosphodiesterase (PDE6): A G-Protein-Activated PDE Regulating Visual Excitation in Rod and Cone Photoreceptor Cells	165	(30)
Rick H. Cote
PDE7	195	(10)
Tamar Michaeli
cAMP-Phosphodiesterase 8 Family	205	(16)
Valeria Vasta
PDE9	221	(16)
Jun Kotera
Kenji Omori
PDE10A: A Striatum-Enriched, Dual-Substrate Phosphodiesterase	237	(18)
Christine A. Strick
Christopher J. Schmidt
Frank S. Menniti
PDE11	255	(22)
Kenji Omori
Jun Kotera
Section B Nonmammalian Phosphodiesterases
Protozoal Phosphodiesterases	277	(24)
Laurent Wentzinger
Thomas Seebeck
Studies of Phosphodiesterase Function Using Fruit Fly Genomics and Transgenics	301	(22)
Shireen-A. Davies
Jonathan P. Day
Section C Phosphodiesterases Functional Significance: Gene-Targeted Knockout Strategies
Insights into the Physiological Functions of PDE4 from Knockout Mice	323	(24)
S.-L. Catherine Jin
Wito Richter
Marco Conti
Regulation of cAMP Level by PDE3B---Physiological Implications in Energy Balance and Insulin Secretion	347	(18)
Allan Z. Zhao
Lena Stenson Holst
Section D Compartmentation in Cyclic Nucleotide Signaling
Heart Failure, Fibrosis, and Cyclic Nucleotide Metabolism in Cardiac Fibroblasts	365	(12)
Sara A. Epperson
Laurence L. Brunton
Role of A-Kinase Anchoring Proteins in the Compartmentation in Cyclic Nucleotide Signaling	377	(18)
Oliwia Witczak
Einar M. Aandahl
Kjetil Tasken
Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation in Cardiac Myocytes	395	(22)
Aniella Abi-Gerges
Liliana R.V. Castro
Francesca Rochais
Gregoire Vandecasteele
Rodolphe Fischmeister
Section E Phosphodiesterases as Pharmacological Targets in Disease Processes
Role of PDEs in Vascular Health and Disease: Endothelial PDEs and Angiogenesis	417	(24)
Therese Keravis
Antonio P. Silva
Laure Favot
Claire Lugnier
Regulation of PDE Expression in Arteries: Role in Controlling Vascular Cyclic Nucleotide Signaling	441	(24)
Donald H. Maurice
Douglas G. Tilley
Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases	465	(20)
Chen Yan
David J. Nagel
Kye-Im Jeon
Role of Cyclic Nucleotide Phosphodiesterases in Heart Failure and Hypertension	485	(16)
Matthew A. Movsesian
Carolyn J. Smith
Molecular Determinants in Pulmonary Hypertension: The Role of PDE5	501	(18)
N.J. Pyne
F. Murray
Rothewelle Tate
M.R. MacLean
Role of PDE5 in Migraine	519	(20)
Christina Kruuse
Phosphodiesterase-4 as a Pharmacological Target Mediating Antidepressant and Cognitive Effects on Behavior	539	(20)
Han-Ting Zhang
James M. O'Donnell
Role of Phosphodiesterases in Apoptosis	559	(24)
Adam Lerner
Eun-Yi Moon
Sanjay Tiwari
Section F Development of Specific Phosphodiesterase Inhibitors as Therapeutic Agents
Crystal Structure of Phosphodiesterase Families and the Potential for Rational Drug Design	583	(24)
Kam Y.J. Zhang
Structure, Catalytic Mechanism, and Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases	607	(20)
Hengming Ke
Huanchen Wang
Bench to Bedside: Multiple Actions of the PDE3 Inhibitor Cilostazol	627	(22)
Junichi Kambayashi
Yasmin Shakur
Yongge Liu
Reinventing the Wheel: Nonselective Phosphodiesterase Inhibitors for Chronic Inflammatory Diseases	649	(18)
Mark A. Giembycz
Medicinal Chemistry of PDE4 Inhibitors	667	(34)
Jeffrey M. McKenna
George W. Muller
Index	701