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9781441932488

Cytochrome P450: Structure, Mechanism, and Biochemistry

by
  • ISBN13:

    9781441932488

  • ISBN10:

    1441932488

  • Edition: 2nd
  • Format: Paperback
  • Copyright: 2010-12-01
  • Publisher: SPRINGER

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Summary

The Second Edition reviews the impressive progress that has been made in the last ten years in cytochrome P450 research. Chapters emphasize structure, mechanism, biochemistry, and regulation. This edition offers expanded coverage of P450 crystal structures, site-specific mutagenesis as a probe of structure and function. New chapters explore the hormonal regulation of P450 enzymes, the cytochrome P450-catalyzed oxidation of eicosanoids, human P450 enzymes, and thiolate-ligated hemoproteins other than P450.

Table of Contents

Model Systems
Models and Mechanisms of Cytochrome P450 Actionp. 3
Comparison of the Peroxidase Activity of Hemoproteins and Cytochrome P450p. 49
Structurally Defined Bacterial Enzymes
Twenty-five Years of P450cam Research: Mechanistic Insights into Oxygenase Catalysisp. 83
Structural Studies on Prokaryotic Cytochromes P450p. 125
Bacterial P450s: Structural Similarities and Functional Differencesp. 151
Structures and Mechanisms of Membrane-Bound P450 Enzymes
Structures of Eukaryotic Cytochrome P450 Enzymesp. 183
NADPH Cytochrome P450 Reductase and Its Structural and Functional Domainsp. 225
Oxygen Activation and Reactivityp. 245
Inhibition of Cytochrome P450 Enzymesp. 305
Regulatory Mechanisms and Physiological Roles of Cytochrome P450
Induction of Cytochrome P450 Enzymes that Metabolize Xenobioticsp. 367
Hormonal Regulation of Liver Cytochrome P450 Enzymesp. 391
Regulation of Steroidogenic and Related P450sp. 419
Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoidsp. 443
Human Cytochrome P450 Enzymesp. 473
Heme-Thiolate Proteins Different from Cytochromes P450 Catalyzing Monooxygenationsp. 537
Appendices
Cytochrome P450 Nomenclature and Alignment of Selected Sequencesp. 575
Rat and Human Liver Cytochromes P450: Substrate and Inhibitor Specificities and Functional Markersp. 607
Indexp. 631
Table of Contents provided by Ingram. All Rights Reserved.

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