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9780849392245

Cytochromes P450

by
  • ISBN13:

    9780849392245

  • ISBN10:

    0849392241

  • Format: Hardcover
  • Copyright: 1996-09-01
  • Publisher: CRC Pr I Llc
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List Price: $249.95

Summary

Cytochromes P450: Metabolic and Toxicological Aspects examines cytochrome P450 proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals. Studying the function of these proteins enables us to:o Predict the pathways and outcome of chemical metabolism to rationalize species, sex, and age differences in toxicityo Anticipate drug interactionso Modify doses to fit the needs of patientsContributions from internationally acknowledged experts are organized into three sections. The first section provides an overview, the next profiles each of the cytochrome P450 families and subfamilies involved in chemical metabolism, and the last section discusses new issues and developments of current interest.This detailed and thorough examination of cytochrome P450 will be a useful source for research scientists, especially those working in the pharmaceutical industry, dealing with the safety evaluation of chemicals and the study of their metabolism, pharmacokinetics, and toxicological properties.

Table of Contents

Foreword, R.L. Smith
General Considerations
Cytochrome P450: From a Single Protein to a Family of Proteins-With Some Personal Reflections, R.W. Estabrook
Role of Metabolism in Chemical Toxicity, N.P.E. Vermeulen
The Chemistry of Cytochrome P450 Reactions, F.P. Guengerich
Cytochrome P450 Families/Subfamilies
The CYP1 Family, K. Kawajiri and S-.I. Hayashi
The CYP2A Subfamily, T.H.K. Chang and D.J. Waxman
The CYP2B Subfamily, R.W. Nims and R.A. Lubet
The CYP2C Subfamily, T.H. Richardson and E.F. Johnson
The CYP2D Subfamily, F.J. Gonzalez
The CYP2E Subfamily, M.J.J. Ronis, K.O. Lindros, and M. Ingelman-Sundberg
The CYP3A Family, P. Maurel
The CYP4 Family, B.G. Lake and D.F.V. Lewis
Current Issues
Expression of Cytochrome P450 Proteins in Disease, C. Ioannides, C.R. Barnett, A. Irizar, and P.R. Flatt
Cytochromes P450 and Immunotoxicity, M. Pirmohamed and B.K. Park
Molecular Modeling of Mammalian Cytochromes P450, D.F.V. Lewis
Index

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