A Decade of HAART The Development and Global Impact of Highly Active Antiretroviral Therapy

by Zuniga, José M; Whiteside, Alan; Ghaziani, Amin; Bartlett, John G

• ISBN13: 9780199225859
• ISBN10: 0199225850
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-12-15
• Publisher: Oxford University Press

Summary

Highly active antiretroviral therapy (HAART) is a therapeutic intervention developed by clinicians and researchers in order to fight the HIV pandemic. It has contributed to a significant reduction in AIDS-related mortality and allowed many previously bed-ridden patients to live healthier, more productive lives. Until the advent of HAART in 1996, a diagnosis of HIV infection was considered a death sentence. A decade later, the disease has been transformed into a serious, yet potentially manageable, medical condition for thousands of people living with HIV/AIDS in the developed world - almost overnight creating a generation of "HIV Survivors" - and forged a global movement to ensure that its Lazarus-like benefit reaches millions more in the developing world. This book reviews the achievements of HAART over the past decade, and explores the challenges that may arise in the future. It recounts key landmarks in the development and introduction of HAART from the perspective of clinicians, researchers, economists, sociologists, and public policy experts, including the co-discoverers of HIV, Luc Montagnier and Robert Gallo. It explores the evolution of the disease, the evolution of HIV treatment, and the economic, social, and public policy impacts of both HIV and the introduction of HAART.

Table of Contents

List of Contributors	p. xiii
List of Figures	p. xvii
List of Tables	p. xxi
List of Acronyms and Abbreviations	p. xxiii
A decade of HAART: trials, tribulations and successes
Introduction	p. 3
A world ravaged by a disease without HAART	p. 7
Turning the world on its ear: defining milestones on the road to HAART	p. 35
The outcome and impact of 10 years of HAART	p. 45
HAART in HIV-infected children: one decade later	p. 63
HAART in high human development countries
Country review: Australia	p. 85
Country review: Chile	p. 103
Country review: Germany	p. 119
Country review: Italy	p. 137
Country review: United States of America	p. 151
US Cohorts review: The HIV Outpatient Study (HOPS) and the Multicenter AIDS Cohort Study (MACS)	p. 171
The French Hospital Database on HIV (FHDH) ANRS CO4	p. 185
EuroSIDA: a prospective observational study of chronic HIV infection across the European continent	p. 195
The Swiss HIV Cohort Study (SHCS)	p. 213
The OPTIMA Cohort	p. 219
HAART in medium human development countries
Country review: Brazil	p. 241
Country review: China	p. 253
Country review: South Africa	p. 275
Country review: Thailand	p. 291
Cohort studies in Brazil: Projeto Praca Onze	p. 311
The HIV Netherlands-Australia-Thailand research collaboration (HIV-NAT)	p. 329
HAART in low human development countries
Country review: Haiti	p. 359
Country review: Malawi	p. 379
Country review: Senegal	p. 395
Country review: Zambia	p. 403
Future challenges in the next decade of HAART
The clinical challenges of lifetime HAART	p. 421
Maintaining and developing health systems to sustain HAART	p. 463
Redefining HIV/AIDS care delivery in the face of human resource scarcity	p. 477
Closing the gap in the next decade of HAART: one world, one standard	p. 497
Index	p. 509
Table of Contents provided by Ingram. All Rights Reserved.