Destruction of Hazardous Chemicals in the Laboratory

by Lunn, George; Sansone, Eric B.

• ISBN13: 9781119848806
• ISBN10: 1119848806
• Edition: 4th
• Format: Hardcover
• Copyright: 2023-01-25
• Publisher: Wiley

Summary

Destruction of Hazardous Chemicals in the Laboratory

Single volume reference providing procedural information for the destruction of a wide variety of hazardous chemicals

Destruction of Hazardous Chemicals in the Laboratory is a practical reference that describes procedures for the destruction of a comprehensive list of hazardous chemicals and provides general methods for the destruction of hazardous chemicals in the laboratory without the need for exotic reagents and equipment.

Unlike most other sources on this subject, detailed reaction parameters are provided to readers. These details will help the reader decide if a procedure will be appropriate. To further aid in reader comprehension, numerous tables throughout the book allow for ready comparison of procedures.

Destruction of Hazardous Chemicals in the Laboratory also describes the critical aspects of various protocols (e.g., UV lamp type and rate of ozone flow).

The updated fourth edition Includes an updated survey of the literature from 2012-2021 and features data mined from 1,500 papers. It also describes recent examples of methods that are generally applicable to organic compounds and greatly expands the section on methods for the destruction of pharmaceuticals in the laboratory.

In this book, readers can expect to find detailed information on:

• Specific methods for the destruction of hazardous chemicals in the laboratory, such as aflatoxins, butyllithium, complex metal hydrides, ethidium bromide, MPTP, nitrosamines, and polycyclic aromatic hydrocarbons
• Methods for the destruction of pharmaceuticals in the laboratory, such as those using ozone, persulfate, and potassium permanganate as well as photolytic degradation procedures
• Procedures for drying organic solvents
• A discussion of the issues concerning nitrosamine formation during the destruction process, particularly when sodium hypochlorite is used
• A variety of indexes, including a general index, cross index of pharmaceuticals and destruction procedures, cross index of dyes and destruction procedures, and cross index of names for dyes and biological stains

Destruction of Hazardous Chemicals in the Laboratory is of immense value to researchers in the laboratory by enabling them to quickly and efficiently get rid of residual amounts of hazardous chemicals when a series of experiments has ended. The procedures in the text can also be incorporated into laboratory protocols.

Author Biography

George Lunn, Ph.D., has been working as a review chemist for the FDA's Office of Pharmaceutical Quality since 1996. Previously he was a senior research scientist in the Environmental Control and Research Program at the NCI-Frederick Cancer Research and Development Center.

Eric B. Sansone, Ph.D., was the director of the Environmental Control and Research Program at the NCI-Frederick Cancer Research and Development Center until his retirement.

Table of Contents

Preface XXX

Acknowledgments          XXX

 

Introduction       XXX

 

SPECIFIC METHODS FOR THE DESTRUCTION OF HAZARDOUS CHEMICALS IN THE LABORATORY      XXX

ACETONITRILE   XXX

ACID HALIDES AND ANHYDRIDES               XXX

AFLATOXINS      XXX

ALKALI AND ALKALINE EARTH METALS    XXX

ALKALI METAL ALKOXIDES            XXX

ANATOXIN-A     XXX

AROMATIC AMINES        XXX

ARSENIC              XXX

AZIDES  XXX

AZO AND AZOXY COMPOUNDS AND TETRAZENES              XXX

BORON TRIFLUORIDE AND INORGANIC FLUORIDES           XXX

BOTULINUM TOXINS      XXX

BREVETOXINS    XXX

BUTYLLITHIUM  XXX

CALCIUM CARBIDE          XXX

CARBAMIC ACID ESTERS XXX

CARBOFURAN   XXX

CHLOROMETHYLSILANES AND SILICON TETRACHLORIDE XXX

N-CHLOROSUCCINIMIDE AND CHLORAMINE-T    XXX

CHLOROSULFONIC ACID XXX

CHROMIUM(VI) XXX

CITRININ              XXX

COMPLEX METAL HYDRIDES        XXX

CYANIDES AND CYANOGEN BROMIDE     XXX

CYLINDROSPERMOPSIN XXX

DIISOPROPYL FLUOROPHOSPHATE           XXX

DIMETHYL SULFATE AND RELATED COMPOUNDS               XXX

 

DYES AND BIOLOGICAL STAINS  XXX

INTRODUCTION XXX

Decontamination Procedures     XXX

Destruction Procedures XXX

Analytical Procedures, Mutagenicity Assays, and Related Compounds      XXX

ETHIDIUM BROMIDE       XXX

HALOETHERS      XXX

HALOGENATED COMPOUNDS    XXX

HALOGENS         XXX

HEAVY METALS XXX

HEXAMETHYLPHOSPHORAMIDE XXX

HYDRAZINES      XXX

HYPOCHLORITES               XXX

MERCURY            XXX

2-METHYLAZIRIDINE       XXX

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE(MPTP)         XXX

MICROCYSTINS XXX

4-NITROBIPHENYL           XXX

3-NITROFLUORANTHENE AND 3-AMINOFLUORANTHENE XXX

NITROGEN TETROXIDE   XXX

N-NITROSO COMPOUNDS: NITROSAMIDES           XXX

N-NITROSO COMPOUNDS: NITROSAMINES          XXX

OCHRATOXIN A XXX

OKADAIC AXID  XXX

ORGANIC NITRILES          XXX

OSMIUM TETROXIDE      XXX

PALYTOXIN         XXX

PATULIN              XXX

PERACIDS            XXX

PEROXIDES AND HYDROPEROXIDES          XXX

PHOSGENE         XXX

PHOSPHORUS AND PHOSPHORUS PENTOXIDE    XXX

PICRIC ACID        XXX

POLYCYCLIC AROMATIC HYDROCARBONS              XXX

POLYCYCLIC HETEROCYCLIC HYDROCARBONS      XXX

-PROPIOLACTONE         XXX

PROTEASE INHIBITORS   XXX

RICIN     XXX

SAXITOXIN          XXX

SELENIUM COMPOUNDS              XXX

SODIUM AMIDE XXX

STERIGMATOCYSTIN      XXX

SULFONYL FLUORIDE ENZYME INHIBITORS            XXX

SULFUR-CONTAINING COMPOUNDS        XXX

T-2 TOXIN AND OTHER TRICOTHECENES XXX

TETRODOTOXIN XXX

TRIACETONE TRIPEROXIDE           XXX

URANYL COMPOUNDS  XXX

 

DESTRUCTION OF PHARMACEUTICALS   XXX

General Considerations XXX

POTASSIUM PERMANGANATE    XXX

NICKEL-ALUMINUM ALLOY REDUCTION XXX

FENTON REACTION         XXX

HYDROGEN PEROXIDE    XXX

OZONE XXX

FERRATE                              XXX

PERSULFATE       XXX

HYDROGEN PEROXIDE AND HORSERADISH PEROXIDASE XXX

SPECIFIC  DEGRADATION PROCEDURES FOR ß-LACTAMS XXX

DECONTAMINATION OF AQUEOUS SOLUTIONS  XXX

MISCELLANEOUS CHEMICAL DEGRADATION PROCEDURES            XXX

General Considerations For Photolytic Procedures            XXX

Photolysis Without Added Reactants (UV Only)  XXX

Photolysis With Hydrogen Peroxide (UV/H2O2)  XXX

PHOTO-FENTON REACTION         XXX

PHOTOLYSIS WITH TITANIUM DIOXIDE (UV/TiO2)              XXX

Photolysis with Zinc Oxide (UV/ZnO)       XXX

Photolysis with Ozone (UV/O3) XXX

Photolysis with Persulfate (UV/Persulfate)           XXX

Photolysis with Chlorine (UV/Cl2)             XXX

Miscellaneous Photolytic Procedures (UV/miscellaneous)              XXX

                XXX

PROCEDURES CLASSIFIED BY METHOD    XXX

General Considerations XXX

Potassium Permanganate            XXX

Fenton Reaction               XXX

Ozone   XXX

Persulfate           XXX

Miscellaneous Procedures           XXX

Photolysis Without Added Reactants (UV only)   XXX

Photolysis with hydrogen peroxide (UV/H2O2)   XXX

Photo-Fenton Reaction XXX

Photolysis with Titanium Dioxide (UV/TiO2)         XXX

Photolysis with Zinc Oxide (UV/ZnO)       XXX

Photolysis with Ozone (UV/O3) XXX

Photolysis with Persulfate (UV/Persulfate)           XXX

Photolysis with Chlorine (UV/Cl2)             XXX

Biologicals           XXX

 

APPENDIX I         XXX

 

APPENDIX II        XXX

 

Index    XXX