Developmental Neurotoxicology Research Principles, Models, Techniques, Strategies, and Mechanisms

by Wang, Cheng; Slikker, William

• ISBN13: 9780470426722
• ISBN10: 0470426721
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-03-01
• Publisher: Wiley

Summary

This book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research.

Author Biography

Cheng Wang is Senior Neurobiologist in the Division of Neurotoxicology at the National Center for Toxicological Research, U.S. Food and Drug Administration. He is the author of over fifty-five peer-reviewed publications and book chapters. Dr. Wang was awarded the Outstanding Performance Award at the Society of Toxicology 44th Annual Meeting and the 2007 FDA Scientific Achievement Award for Excellence in Laboratory Science. William Slikker, Jr., is the Director of the National Center for Toxicological Research, U.S. Food and Drug Administration. He has over 260 peer-reviewed scientific publications. Dr. Slikker has served as coeditor of several books and is an Associate Editor of the journals Neuro Toxicology and Toxicological Sciences.

Table of Contents

Preface	p. xi
Contributors	p. xiii
Models, Approaches, and Challenges in Neurotoxicity Research during Development	p. 1
Approaches and Models for Evaluating the Toxic effects of Anesthetics in the Developing Nervous System	p. 5
Systems Biology Approaches to Neurotoxicity Studies during Development	p. 25
Behavioral Approaches for Assessing Nervous System Function during Development in Animal Models	p. 39
Applications of Unbiased Stereology to Neurodevelopmental Toxicology	p. 53
Effects of Anesthetics and their Potential Neurotoxicity during Development	p. 77
Neurotoxic Effects of Anesthetics and Potential Protective Agents	p. 79
Perinatal Rhesus Monkey Models and Anesthetic-Induced Neuronal Cell Death	p. 95
Effects of Gaseous Anesthetic Combinations during Development	p. 111
Perinatal Anesthetic Administration and Short/Long-Term Behavioral Deficits	p. 129
The Developmental basis of Adolescent or Adult Disease	p. 141
Developmental Lead Exposure, Epigentics and Late Onset Alzheimer's Disease	p. 143
Developmental Trajectories of Autism and Environmental Exposures-What We Know and Where We Need to Go	p. 163
Actions of Manganese on Pubertal Development	p. 195
Exposure of the Developing Brain to Polychlorinated Biphenyls Influences the Susceptibility of the Adult Brain to Stress	p. 211
A Neurodevelopmental Origin for Pakinson's Disease: A Link to the Fetal basis for Adult Disease Hypothesis	p. 231
Genetic and Environmental Factors in Attention-Deficit Hyperactivity Disorder	p. 257
Risk Assessment of Methyl Mercury and its Effects on Neurodevelopment	p. 275
Fish Nutrients and Methylmercury: A View From the Laboratory	p. 279
Neurodevelopmental Effects of Maternal Nutrition Status and Exposure to Methyl Mercury from Eating Fish during Pregnancy: Evidence from the Seychelles Child Development Study	p. 319
Methylmercury Neurotoxicology: From Rare Poisonings to Silent Pandemic	p. 335
Oxidative Stress and Methylmercury-Induced Neurotoxicity	p. 357
Learning Deficits and Depression-Like Behaviors Associated with Developmental Methylmercury Exposures	p. 387
Methylmercury Effects on Neural Developmental Signaling Pathways	p. 409
Autism Spectrum Disorders	p. 435
Neurodevelopmental Toxicology and Autism Spectrum Disorders	p. 439
Redox Imbalance and the Metabolic Pathology of Autism	p. 477
Neuroinflammation and Autism	p. 501
Autism, Peripheral Immunity, and Polybrominated Diphenyl Ethers	p. 521
An Emerging Gene-Environment Interaction model: Autism Spectrum Disorder Phenotypes Resulting from Exposure to Environmental Contaminants during Gestation	p. 543
Strategies and Progress In Epilepsy Research	p. 563
Neonatal Seizures	p. 565
Experimental Models of Epileptogenesis	p. 581
Effect of Seizures on the Developing Brain: Lessons from the Laboratory	p. 601
Index	p. 617
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