What is included with this book?
Michael Barratt is an independent consultant and previously?Senior Director and Technology Platform Leader at Pfizer's Global Indications Discovery Research Unit. He has?over 15?years of experience in preclinical drug discovery research and leadership.
Donald Frail is an independent consultant and previously?Vice President of Pfizer Global Research and Development and Head of Pfizer's Global Indications Discovery Research Unit. He has over 20 years of industrial research and management experience in preclinical drug discovery and early clinical research.
Introduction | |
Drug Repositioning: Business Case, Strategies and Operational Considerations | |
Drug Repositioning: The Business Case and Current Strategies to Repurpose Shelved Candidates and Marketed | |
Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs | |
Clinical and operational considerations in repositioning marketed drugs and drug candidates | |
Regulatory considerations and strategies for drug repositioning | |
Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs | |
Computational and Bioinformatic Strategies for Drug Repositioning | |
Mining scientific and clinical databases to identify novel uses for existing drugs | |
Predicting the polypharmacology of drugs: Identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches | |
Systemic phenotypic screening for novel synergistic combinations: A new paradigm for repositioning existing drugs | |
Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates | |
Old Drugs Yield New Discoveries: Examples from the Prodrug, Chiral Switch and Site-Selective Deuteration Strategies | |
Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry | |
Repurposing Drugs for Tropical Diseases: Case Studies and Open-source Screening Initiatives | |
Drug Repositioning Efforts by Non-Profit Foundations | |
Repositioning Drugs for Leukemia and Lymphoma: Perspective From The Leukemia & Lymphoma Society | |
Repositioning drugs for Parkinson's disease: Perspective from the Michael J. Fox Foundation | |
Repositioning drugs for Polycystic Kidney Disease (PKD): Perspectives from the Polycystic Kidney Disease Foundation | |
Business Development Strategies in the Repositioning Industry | |
A Case Study in Drug Repositioning: Sosei | |
Table of Contents provided by Publisher. All Rights Reserved. |
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