Drug-DNA Interactions Structures and Spectra

by Nakamoto, Kazuo; Tsuboi, Masamichi; Strahan, Gary D.

• ISBN13: 9780470370612
• ISBN10: 0470370610
• Edition: 1st
• Format: eBook
• Copyright: 2008-07-14
• Publisher: Wiley

Summary

Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.

Author Biography

Kazuo Nakamoto pioneered the use of metal isotopes to elucidate the involvement of metals in low-frequency vibrations in metallic complexes and was among the first to use matrix isolation techniques to prepare and characterize unstable specie. He is the author of Infrared and Raman Spectra of Inorganic and Coordination compounds, Fifth Edition (Wiley).

Masamichi Tsuboi studies DNA and RNA structures, drug-DNA interaction, protein conformation, protein-nucleic acid recognition, and virus structure using a variety of physicochemical and biomedical techniques including X-ray diffraction, UV-Visible, IR/Raman , and NMR spectroscopy.

Gary D. Strahan uses physico-chemical techniques to understand biological systems relevant to pharmaceutical discovery and agricultural and natural product analyses. His work has emphasized spectroscopic methods, NMR, and computational modeling to determine the structures and properties of multistranded DNA, drug-DNA complexes, carbohydrates, and other biomolecules, as well as metabonomic and chemometric studies.

Table of Contents

Preface.

Introduction.

1. DNA Structures and Spectra.

1.1. DNA Structures.

1.2. Electronic Spectra.

1.3. Vibrational Spectra.

1.4. NMR Spectra.

1.5. Electron Spin Resonance Spectra.

1.6. X-Ray Crystallography.

1.7. Molecular Modeling an molecular Mechanics.

2. Intercalating Drugs.

2.1. Acridine Dyes.

2.2. Ethidium Bromide.

2.3. Aclacinomycin.

2.4. Sequence Preference.

2.5. Bis- and Tris- Intercalators.

3. Groove- Binding Drugs.

3.1. Netropsin and Distamycin.

3.2. Derivatives of Netropsin and Distamycin.

3.3. Hoechst 33258, SN6999, and their Derivatives.

3.4. Chromomycin, Mithramycin, and Other GC Binders.

3.5. Groove Binding and Intercalation.

4. Covalent Bonding Drugs.

4.1. (+) CC1065 and Related Drugs.

4.2. Anthramycin and Tomaymycin.

4.3. Ecteinascidins.

4.4. Mitomycins.

4.5. Intercalating Alkylators.

5. Strand-Breaking Drugs.

5.1. Bleomycins.

5.2. Enediyne Antibiotics.

6. Metal-Containing Drugs.

6.1. Cisplatin.

6.2. Cisplatin Derivatives.

6.3. Transplatin and Derivatives.

6.4. Monofunctional Platinum Complexes.

6.5. Polynuclear and High-valent Platinum Complexes.

6.6. Complexes Containing Other Metals.

Appendixes.

Index.