9780198529972

Economic Evaluation in Clinical Trials

by ; ; ;
  • ISBN13:

    9780198529972

  • ISBN10:

    019852997X

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2007-03-29
  • Publisher: Oxford University Press
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Summary

It is becoming increasingly important to examine the relationship between the outcomes of a clinical trial and the costs of the medical therapy under study. The results of such analysis can affect reimbursement decisions for new medical technologies, for example drugs, devices or diagnostics;aid companies seeking to make claims about the cost-effectiveness of their product; allow early consideration of the economic value of therapies, which may be important to improving initial adoption decisions; or address the requirements of regulatory bodies. Economic evaluation in clinical trialsuses a consistent set of data collected within the trial, or by projection from this data, and avoids having to incorporate unrelated (and potentially inconsistent) data from many different sources. This book provides a practical guide to conducting economic evaluation in ongoing clinical trials. It covers issues and techniques related to the collection of both cost and outcome data, as well as a framework for reporting and interpreting economic reports from clinical trials. This is illustratedby detailed supporting examples and exercises, designed to teach the reader how to apply this model. These exercises are supported with datasets, programmes and solutions made available online.ABOUT THE SERIES - series editors Alastair Gray and Andrew BriggsEconomic evaluation of health intervention is a growing specialist field, and this series of practical handbooks tackles, in depth, topics superficially addressed in more general health economics books. Each volume includes illustrative material, case histories and worked examples to encourage thereader to apply the methods discussed, with supporting material provided online. This series is aimed at health economists in academia, the pharmaceutical industry and the health sector, those on advanced health economics courses, and health researchers in associated fields.

Table of Contents

Series prefacep. v
Web resourcesp. vii
Acknowledgmentp. ix
Introductionp. 1
Designing economic evaluations in clinical trialsp. 7
Valuing medical service usep. 31
Assessing quality-adjusted life yearsp. 59
Analyzing costp. 89
Analyzing censored costp. 115
Comparing cost and effect: point estimates for cost-effectiveness ratios and net monetary benefitp. 133
Understanding sampling uncertainty: the conceptsp. 145
Sampling uncertainty: calculation, sample size and power, and decision criteriap. 179
Evaluating transferability of the results from trialsp. 207
Relevance of trial-based economic analysesp. 229
Indexp. 237
Table of Contents provided by Ingram. All Rights Reserved.

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