Evidence-Based Hematology

by Crowther, Mark A.; Ginsberg, Jeffrey; Schünemann, Holger; Meyer, Ralph M.; Lottenberg, Richard

• ISBN13: 9781405157476
• ISBN10: 140515747X
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-07-21
• Publisher: BMJ Books

Summary

This unique new book uses a series of focussed questions, comprehensive literature evaluations and structured grades of recommendation to provide evidence for the treatment of hematological disorders, both malignant and benign. With contributions from leading international experts who have a real understanding of evidence-based medicine the book provides comprehensive reviews accompanied by clinical commentaries and recommendations on the best treatment regimes to adopt for individual patients. The book is split into two sections: the first examines the methodology underlying evidence based practice, and the second concentrates on the clinical practice of hematology, providing current "best evidence" to guide practice in a series of well-defined clinical situations. This clinical reference is an invaluable source of evidence-based information distilled into guidance for clinical practice which will be welcomed by practitioners, trainees and associated health professionals.

Author Biography

Dr Mark Crowther is Associate Professor of Medicine and Program Director of the Adult Hematology Residency Training Program at McMaster University. He is a member of the Canadian Critical Care Trials Group.

Dr. Jeffrey Ginsberg is a leading expert in the diagnosis, prevention and management of venous thromboembolism and has led many of the "practice changing" studies published in this area in the last 20 years. He is the recipient of numerous awards and distinctions, most recently an endowed chair at McMaster University allowing him to pursue further research in venous and arterial thrombosis.

Dr. Holger Schünemann is a leading expert in evidence based practice with a particular interest in the development and widespread dissemination of validated evidence scoring criteria. Dr. Schünemann has played an important role in the evolution of evidence based guidelines currently written by organizations such as the American College of Chest Physicians and the American Thoracic Society.

Dr. Ralph Meyer has recently joined the National Cancer Institute of Canada after a distinguished career at McMaster University. Dr. Meyer is responsible for administering the Clinical Trial Program at the NCIC. The NCIC has led or participated in many national and international studies which guide current best treatment practices for disorders such as Hodgkin's disease, multiple myeloma and other hematologic malignancies.

Dr. Richard Lottenberg is a professor of medicine and past Division Chair of the division of Hematology and Oncology. He is currently the Training Program Director at the University of Florida and is widely regarded as an expert in the evidence based management of sickle cell anemia.

Table of Contents

About the Contributors

Preface

A Guide to the Evidence

Rating the quality of evidence and making recommendations

An overview of systematic reviews

Interpreting results of clinical research

Finding the evidence

Applying EBM in clinical practice

Using evidence to guide the diagnosis of disease

Diagnosis of Deep Vein Thrombosis

Diagnosis of Pulmonary Embolism

Initial Therapy of Deep Vein Thrombosis and Pulmonary Embolism

Long-term Anticoagulation in Venous Thromboembolism

Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism

Inferior Vena Cava Interruption

Management of Venous Thromboembolism in Pregnancy

Pediatric Thrombosis

Bridging Anticoagulation in Patients who Require

Evidence-based approach to the diagnosis and management of thrombotic thrombocytopenic purpura

Diagnosis and Management of Disseminated Intravascular Coagulation

Diagnosis and Management of Hereditary Bleeding Disorders

Diagnosis and Management of Acquired Bleeding Disorders

Diagnosis and Management of Heparin-Induced Thrombocytopenia

Management of Antiphospholipid Antibody Syndrome

Clinical Questions in iron overload

Aplastic Anemia

Acquired Anemias

Immune thrombocytopenic purpura

Neutropenia

Hypereosinophilia

Porphyrias

Membrane and Enzyme Abnormalities of the Erythrocyte

Sickle cell disease

Evidence-based treatment of thalassemia major

Acute Lymphoblastic Leukemia in Adults

Acute Myeloblastic Leukemia in Adults

Acute Myeloid Leukemia in Adults

Current Areas of Controversy in the Treatment of Patients

Chronic Lymphocytic Leukemia

Chronic Myelocytic Leukemia

Burkitt's Lymphoma

Primary Central Nervous System Lymphoma

Diffuse Large B-cell Lymphoma

Follicular Lymphoma

Lymphoblastic Lymphoma

Mantle Cell Lymphoma

Peripheral T-cell Lymphoma

Classical Hodgkin Lymphoma

Nodular Lymphocyte Predominant Hodgkin Lymphoma

Essential Thrombocythemia

Management of Patients with Polycythemia Vera

Multiple Myeloma

Waldenstroms Macroglobulinemia

Use of Hematopoietic Growth Factors for Hematologic Malignancies

Index

Table of Contents provided by Publisher. All Rights Reserved.