The Extracellular Matrix

by Mecham, Robert P.

• ISBN13: 9783642165542
• ISBN10: 3642165540
• Format: Hardcover
• Copyright: 2011-02-16
• Publisher: Springer Verlag

Summary

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling.This volume of the series 'œBiology of Extracellular Matrix' provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment.  Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Table of Contents

An Overview of Extracellular Matrix Structure and Function	p. 1
Fibronectin and Other Adhesive Glycoproteins	p. 41
Collagens, Suprastructures, and Collagen Fibril Assembly	p. 77
Basement Membranes	p. 117
Hyaluronan and the Aggregating Proteoglycans	p. 147
Small Leucine-Rich Proteoglycans	p. 197
Microfibrils and Fibrillin	p. 233
Elastin	p. 267
Lysyl Oxidase and Lysyl Oxidase-Like Enzymes	p. 303
The Fibulins	p. 337
Matricellular Proteins	p. 369
Index	p. 415
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