Familial Breast and Ovarian Cancer: Genetics, Screening and Management

by Edited by Patrick J. Morrison , Shirley V. Hodgson , Neva E. Haites

• ISBN13: 9780521803731
• ISBN10: 052180373X
• Format: Hardcover
• Copyright: 2002-12-09
• Publisher: Cambridge University Press

Summary

This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in understanding the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in diagnosis, genetics, screening, prevention, and management. In addition, the volume discusses ethical and insurance issues, distinct cultural differences in breast cancer and use of recently devised cancer genetics clinics. The different referral criteria and patterns to these clinics are detailed.

Table of Contents

List of contributors	ix
Foreword	xiii
Helena Kennedy
Preface	xv
Part 1 Molecular biology and natural history	1	(234)
Introduction	3	(3)
Patrick J. Morrison
Shirley V. Hodgson
Neva E. Haites
Overview of the clinical genetics of breast cancer	6	(16)
Neva Haites
Helen Gregory
Cowden syndrome and related disorders	22	(21)
Charis Eng
Overview of the clinical genetics of ovarian cancer	43	(30)
Pierre O. Chappuis
William D. Foulkes
Ovarian and breast cancer as part of hereditary non-polyposis colorectal cancer (HNPCC) and other hereditary colorectal cancer syndromes	73	(8)
H. F. A. Vasen
M. A. Nooy
The natural history of hereditary breast cancer	81	(27)
Pierre O. Chappuis
Dominique Stoppa-Lyonnet
Bernard Asselain
William D. Foulkes
Pathology of the breast and ovary in mutation carriers	108	(17)
Sunil R. Lakhani
Adrienne M. Flanagan
Risk estimation for familial breast and ovarian cancer	125	(18)
Jenny Chang-Claude
Heiko Becher
Part 2 Screening
Developing a cancer genetics service: a Welsh model	143	(14)
Jonathon Gray
Referral criteria for cancer genetics clinics	157	(9)
Diana M. Eccles
Guidelines for the development of cancer genetics services	166	(28)
Neva E. Haites
Shirley V. Hodgson
Cultural and educational aspects influencing the development of cancer genetics services in different European countries	194	(10)
Shirley V. Hodgson
Screening, detection and survival patterns of breast and other cancers in high-risk families	204	(16)
Pal Moller
C. Michael Steel
Screening for familial ovarian cancer	220	(15)
Barnaby Rufford
Usha Menon
Ian Jacobs
Part 3 Management	235	(158)
Management of BRCA1/2 mutation carriers	237	(38)
Pierre O. Chappuis
William D. Foulkes
Management of familial ovarian cancer	275	(11)
Dirk Brinkmann
Ian Jacobs
Prophylactic mastectomy in mutation carriers	286	(9)
D. G. R. Evans
F. I. Lalloo
A. D. Baildam
Psychosocial aspects of genetic counselling for breast and ovarian cancer	295	(11)
Alison Bish
Steven Sutton
BRCA1/2 testing: uptake and its measurement	306	(33)
Lucy Brooks
Andrew Shenton
F. I. Lalloo
D. G. R. Evans
Breast cancer genetics: ethical, social and insurance issues	339	(33)
Patrick J. Morrison
C. Michael Steel
Gene therapy for breast and ovarian cancer	372	(12)
Richard Kennedy
Patrick G. Johnston
Future directions	384	(9)
Patrick J. Morrison
Shirley V. Hodgson
Neva E. Haites
Index	393