Fatty Liver Disease: NASH and Related Disorders

by Editor: Geoffrey C. Farrell; Editor: Jacob George; Editor: Pauline de la M. Hall; Editor: Arthur J. McCullough (Case Western Reserve University)

• ISBN13: 9781405141000
• ISBN10: 140514100X
• Format: eBook
• Copyright: 2008-06-01
• Publisher: Wiley-Blackwell

Summary

Fatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It appeals to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease. It will improve your diagnostic acumen for people with abnormal liver tests, advance your knowledge about this important subject and help with your specialist or undergraduate exams, and management of a common disorder.

Table of Contents

Contributors

Preface

Overview: an introduction to NASH and related fatty liver disorders

Pathology of hepatic steatosis, NASH and related conditions

The epidemiology and risk factors of NASH

Insulin resistance in NAFLD: potential mechanisms and therapies

NASH as part of the metabolic (insulin resistance) syndrome

NASH is a genetically determined disease

The pathogenesis of NASH: human studies

Animal models of steatohepatitis

Fatty acid metabolism and lipotoxicity in the pathogenesis of NAFLD/NASH

Cytokines and inflammatory recruitment in NASH: experimental and human studies

Mitochondrial injury and NASH

Cell biology of NASH: fibrosis and cell proliferation

Clinical manifestations and diagnosis of NAFLD

The clinical outcome of NAFLD including cryptogenic cirrhosis

Practical approach to the diagnosis and management of people with fatty liver diseases

Management of NASH: current and future perspectives on treatment

NAFLD, NASH and orthotopic liver transplantation

NAFLD/NASH is not just a æWesternÆ problem: some perspectives on NAFLD/NASH from the East

NAFLD/NASH in children

Steatohepatitis resulting from intestinal bypass

Specific disorders associated with NAFLD

Hepatocellular carcinoma in NAFLD

Does NASH or NAFLD contribute to comorbidity of other liver diseases?

Recent advances

Index

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