Fetal Therapy

by Kilby, Mark D.; Oepkes, Dick; Johnson, Anthony

• ISBN13: 9781107012134
• ISBN10: 1107012139
• Edition: 1st
• Format: Hardcover
• Copyright: 2013-01-28
• Publisher: Cambridge Univ Pr

Summary

Fetal treatment, particularly complex fetal therapy, is an emergent and expanding field. This comprehensive text focuses on areas of fetal disease and pathophysiology that can be treated in utero and the benefits and problems with such therapy. Both medical (non-invasive) and surgical procedures are discussed, drawing on the expertise of an internationally renowned author team. Each chapter includes a comprehensive overview of the basic science underlying fetal pathology, as well as discussing the highest level of technical performance of fetal interventions. Contributions from fetal therapy 'centers-of-excellence' around the world collectively emphasize the need for an evidence-based approach to the field. This volume is useful both as a quick reference guide to the latest fetal therapy options and as an in-depth study book for maternal-fetal medicine and neonatology specialists at any stage of their career who are seeking to acquire essential background knowledge. Indispensable on any bookshelf in fetal medicine units.

Table of Contents

Preface

Foreword

General Principles

The rationale for fetal therapy

Insights into pathogenesis of adult cardiovascular disease from fetal animal studies

Human embryology: molecular mechanisms of embryonic disease

Ethics of fetal therapy

Fetal therapy choices: about risks, emotions, and the doctor's role in the decision making process

Fetal Disease: Pathogenesis and Principles

Red cell alloimmunization: immunobiology, clinical disease, and management

Fetal and neonatal alloimmune thrombocytopenia

Fetal dysrhythmias: the effects of antiarrhythmic therapy on the immature heart

Fetal dysrhythmias: clinical management

Structural heart disease: embryology

Structural heart disease: genetic influences

Structural heart disease: fetal cardiac interventions

Manipulation of amniotic fluid volume: homeostasis of fluid volumes in the amniotic cavity

Manipulation of amniotic fluid volume: oligohydramnios and polyhydramnios

Twin-to-twin transfusion syndrome: scientific basis

Twin-to-twin transfusion syndrome: placental circulation

Twin-to-twin transfusion syndrome: cardiovascular manifestations

Twin-to-twin transfusion syndrome: treatment by fetoscopic laser ablation

Twin-to-twin transfusion syndrome: management of stage I disease

Twin reverse arterial perfusion (TRAP) sequence: pathophysiology

Twin reverse arterial perfusion (TRAP) sequence: in-utero treatment

Fetal infections: fetal immune responses to congenital infections

Fetal infections: clinical management

Fetal urinary tract obstruction: pathophysiology

Fetal urinary tract obstruction: prenatal assessment and prognosis

Fetal urinary tract obstruction: fetal cystoscopy

Fetal urinary tract obstruction: in-utero intervention

Fetal lung growth, development and lung fluid: physiology and pathophysiology

Fetal lung growth, development, and lung fluid: clinical management of pleural effusion and pulmonary pathology

Neural tube defects: pathophysiology and prevention

Neural tube defects: clinical management

Fetal tumors: pathophysiology

Fetal tumors: clinical management

Intrauterine growth restriction: placental basis and implications for clinical practice

Intrauterine growth restriction: differential diagnosis and management

Congenital diaphragmatic hernia: pathophysiology

Congenital diaphragmatic hernia: clinical antenatal management

Fetal stem cell transplantation: stem cell biology basics

Fetal stem cell transplantation: clinical potential

Fetal stem cell transplantation: fetal tissue engineering

Gene therapy: physiological principles and clinical potential

The future: fetal therapies and translation studies: global alignment, coordination and collaboration in perinatal research: The Global Obstetrics Network (GONet) initiative

Index

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