Frontiers in Antimicrobial Resistance

by White, David G.; Alekshun, Michael N.; Mcdermott, Patrick F.; Levy, Stuart B.

• ISBN13: 9781555813291
• ISBN10: 1555813291
• Format: Hardcover
• Copyright: 2005-08-24
• Publisher: Amer Society for Microbiology

Summary

Frontiers in Antimicrobial Resistance: a Tribute to Stuart B. Levy offers a unique examination of the state of antimicrobial and anticancer drug resistance. Written by acknowledged experts who have spent time in Dr. Levy's laboratory or who have otherwise collaborated with him professionally, this new volume is a tribute to Dr. Levy and acknowledges his significant contributions to the field. Offers a unique scope of coverage, integrating the latest science with public education programs to use antimicrobials appropriately Provides comprehensive and detailed coverage of the most current research on antimicrobial resistance Presents contributions from acknowledged experts in the field Covers the most important clinical pathogens and the major drug classes Addresses an urgent medical crisis Recognizes Dr. Stuart B. Levy and his vital contributions to the field

Table of Contents

Contributors	ix
Foreword	xiii
Preface	xv
Introduction	xvii
Photographs	xix
I. Tetracyclines and Resistance
Introduction:
Michael N. Alekshun
Tetracycline Resistance: Efflux, Mutation, and Other Mechanisms	3	(16)
Frederic M. Sapunaric
Mila Aldema-Ramos
Laura M. McMurry
Tetracycline Resistance Due to Ribosomal Protection Proteins	19	(10)
Marilyn C. Roberts
Discovery and Industrialization of Therapeutically Important Tetracyclines	29	(12)
Mark L. Nelson
Steven J. Projan
II. Single Antimicrobial Resistance Mechanisms
Introduction:
Patrick F. McDermott
Fluoroquinolone Resistance	41	(12)
Jordi Vila
β-Lactam Resistance in the 21st Century	53	(13)
George Jacoby
Karen Bush
Macrolide, Lincosamide, Streptogramin, Ketolide, and Oxazolidinone Resistance	66	(19)
Marilyn C. Roberts
Joyce Sutcliffe
Aminoglycoside Resistance Mechanisms	85	(16)
David D. Boehr
Ian F. Moore
Gerard D. Wright
Glycopeptide Resistance in Enterococci	101	(23)
Florence Depardieu
Patrice Courvalin
Phenicol Resistance	124	(27)
Stefan Schwarz
David G. White
III. Multiple Antimicrobial Resistance Mechanisms
Introduction:
Patrick F. McDermott
Multiple Antimicrobial Resistance	151	(14)
Anthony M. George
Metal Resistance Loci of Bacterial Pathogens	165	(9)
Anne O. Summers
Biocides and Resistance	174	(17)
Bonnie M. Marshall
Laura M. McMurry
Merri C. Moken
The Nexus of Oxidative Stress Responses and Antibiotic Resistance Mechanisms in Escherichia coli and Salmonella	191	(7)
Bruce Demple
The mar Locus	198	(11)
Thamarai Schneiders
Herbert Haechler
William Yan
The mar Regulon	209	(15)
Teresa M. Barbosa
Pablo J. Pomposiello
Identification of Mar Mutants among Clinical Bacterial Isolates	224	(11)
JoAnn Dzink-Fox
Margret Oethinger
Structure and Function of MarA and Its Homologs	235	(12)
Robert G. Martin
Judah L. Rosner
Function and Structure of MarR Family Members	247	(14)
Michael N. Alekshun
James F. Head
Role, Structure, and Function of Multidrug Efflux Pumps in Gram-Negative Bacteria	261	(14)
Hiroshi Nikaido
Role of Multidrug Efflux Pumps in Gram-Positive Bacteria	275	(14)
Glenn W. Kaatz
IV. Antimicrobial Resistance in Select Pathogens
Introduction:
David G. White
Advances in Vancomycin Resistance: Research in Staphylococcus aureus	289	(10)
Keiichi Hiramatsu
Maria Kapi
Yutaka Tajima
Longzhu Cui
Suwanna Trakulsomboon
Teruyo Ito
Enterococcus	299	(15)
Roland Leclercq
Patrice Courvalin
Streptococcus pneumoniae	314	(16)
Joyce Sutcliffe
Marilyn C. Roberts
Helicobacter and Campylobacter	330	(10)
Patrick F. McDermott
Diane E. Taylor
Anaerobes	340	(15)
Isabelle Podglajen
Jacques Breuil
Ekkehard Collatz
Pseudomonas aeruginosa	355	(12)
Keith Poole
Antibiotic Resistance in Salmonella and Shigella	367	(7)
E. J. Threlfall
Antibiotic Resistance in Escherichia coli	374	(13)
Mark A. Webber
Laura J. V. Piddock
Epidemiology and Treatment Options for Select Community-Acquired and Nosocomial Antibiotic-Resistant Pathogens	387	(14)
John E. Gustafson
John D. Goldman
Drug-Resistant Falciparum Malaria: Mechanisms Consequences, and Challenges	401	(13)
Karen Hayton
Rick M. Fairhurst
Bronwen Naude
Xin-zhuan Su
Thomas E. Wellems
Antimicrobial Susceptibility Testing of Bacterial Agents of Bioterrorism: Strategies and Considerations	414	(11)
Fred C. Tenover
V. Ecology and Fitness of Drug Resistance
Introduction:
David G. White
Fitness Traits in Soil Bacteria	425	(11)
Fabrice N. Gravelat
Steven R. Strain
Mark W. Silby
Ecology of Antibiotic Resistance Genes	436	(10)
Abigail A. Salyers
Hera Vlamakis
Nadja B. Shoemaker
Resistance in the Food Chain and in Bacteria from Animals: Relevance to Human Infections	446	(19)
Vincent Perreten
Antimicrobial Use in Plant Agriculture	465	(8)
Anne K. Vidaver
VI. Drug Resistance in Cancer Cells
Introduction:
Michael N. Alekshun
Mechanisms of Resistance to Anticancer Agents	473	(27)
Michael P. Draper
Graham K. Jones
Christopher J. Gould
David E. Modrak
Development of Resistance to Anticancer Agents	500	(17)
David E. Modrak
Graham K. Jones
Michael P. Draper
VII. Policy, Education, and Exploration
Introduction:
Michael N. Alekshun
Commentary. The Birth of the Alliance for the Prudent Use of Antibiotics (APUA)	517	(2)
Ellen Koenig
Alliance for the Prudent Use of Antibiotics: Scientific Vision and Public Health Mission	519	(9)
Kathleen T. Young
Thomas F. O'Brien
Antimicrobial Use in Animals in the United States: Developments in Policy and Practice	528	(9)
Stephen J. DeVincent
Christina Viola
From Perplexing Proteins to Paratek Pharmaceuticals: One Scientific Front Forged by Stuart B. Levy	537	(14)
Mark L. Nelson
S. Ken Tanaka
Afterword. Learning and Teaching: a Personal Reflection	551	(4)
Julian Davies
Concluding Remarks	555	(4)
Jay A. Levy
Index	559