Fundus Autofluorescence

by Lois, Noemi; Forrester, John V.

• ISBN13: 9781582557991
• ISBN10: 1582557993
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-07-09
• Publisher: LWW

Summary

This detailed full-color textbook provides up-to-date information on the use of fundus autofluorescence imaging in the evaluation of retinal disease. The basic science chapters explain the synthesis and degradation of lipofuscin, the main fluorophore in the retina generating the fundus autofluorescence signal; the techniques available to image and quantify fundus autofluorescence and their basis; and the anatomo-pathologic correlations of autofluorescence findings. The clinical science chapters describe the distribution of autofluorescence across the fundus in the healthy eye and in various diseases--age-related maculopathy and macular degeneration, inherited retinal dystrophies, posterior uveitis, central serous chorioretinopathy, macular holes and related conditions, and intraocular tumors. Emphasis is on the value of fundus autofluorescence as a diagnostic and prognostic tool. The authors discuss the clinical utility of fundus autofluorescence in the context of other imaging techniques, such as fluorescein and indocyanine green angiography and optical coherence tomography. Each chapter also points out the value of fundus autofluorescence findings in understanding the pathogenesis of the condition, and provides a comprehensive update on all aspects of the condition. A companion Website will offer the fully searchable text and an image bank.

Table of Contents

BASIC SCIENCE 1. Lipofuscin: The "Wear and Tear" Pigment Sabrina S. Seehafer and David. A. Pearce 2. Lipofuscin of the Retinal Pigment Epithelium Michael E. Boulton 3. Lipofuscin: The Origin of the Autofluorescence Signal François Delori 4. Lipofuscin and Autofluorescence in Experimental Animal Models Heping Xu 5. Imaging Techniques of Fundus Autofluorescence Steffen Schmitz-Valckenberg and Fred W. Fitzke 6. Near-Infrared Fundus Autofluorescence Ulrich Kellner and Simone Kellner 7. Interpreting Fundus Autofluorescence Alan C. Bird 8. Quantifying Fundus Autofluorescence Dietrich Schweitzer CLINICAL SCIENCE Fundus Autofluorescence in the Healthy Eye 9. Fundus Autofluorescence in the Healthy Eye R. Theodore Smith Fundus Autofluorescence in the Diseased Eye 10. Age-Related Maculopathy and Age-Related Macular Degeneration 10A. Fundus Autofluorescence in Age-Related Maculopathy Almut Bindewald-Wittich, Robert P. Finger, and Frank G. Holz 10B. Fundus Autofluorescence in Neovascular Age-Related Macular Degeneration Ehab Abdelkader, Vikki McBain, and Noemi Lois 10C. Fundus Autofluorescence in Atrophic Age-Related Macular Degeneration Steffen Schmitz-Valckenberg, Monika Fleckenstein, Almut Bindewald-Wittich, Hendrik P.N. Scholl, and Frank G. Holz 11. Inherited Retinal Dystrophies 11A. Fundus Autofluorescence in Retinitis Pigmentosa Anthony G. Robson, Isabelle Audo, Phil Hykin, and Andrew R. Webster 11B. Fundus Autofluorescence in Cone and Cone-Rod Dystrophies Michel Michaelides 11C. Fundus Autofluorescence in X-linked Retinoschisis Irena Tsui and Stephen H. Tsang 11D. Fundus Autofluorescence in Leber Congenital Amaurosis Hendrik P.N. Scholl and Bettina Wabbels 11E. Fundus Autofluorescence in Pattern Dystrophy Susan M. Downes 11F. Fundus Autofluorescence in Best Disease Markus Preising 11G. Fundus Autofluorescence in Stargardt's Disease Vikki McBain and Noemi Lois 11H. Fundus Autofluorescence in Maternal Inherited Diabetes and Deafness (MIDD) Caren Bellmann and Pamela Rath 11I. Fundus Autofluorescence in Choroideremia Agnes B. Renner 12. Fundus Autofluorescence in Posterior Uveitis John V. Forrester, Lucia Kuffová, Vikki McBain, and Noemi Lois 13. Fundus Autofluorescence in Central Serous Chorioretinopathy Carsten Framme 14. Macular Holes and Related Conditions 14A. Fundus Autofluorescence in Full-Thickness Macular Holes Andrea von Rückmann 14B. Fundus Autofluorescence in Lamellar Macular Holes and Pseudoholes Ferdinando Bottoni 15. Fundus Autofluorescence of Intraocular Tumors: Choroidal Nevus and Melanoma Daniel Lavinsky, Rubens Belfort Mattos Neto, Eduardo V. Navajas, and Rubens Belfort Mattos, Jr.