The Future of the Oocyte: Basic and Clinical Aspects

by Eppig, John; Hegele-Hartung, Christa

• ISBN13: 9783540437475
• ISBN10: 3540437479
• Format: Hardcover
• Copyright: 2002-12-01
• Publisher: Springer Verlag

Summary

Since the first successful transfer of an in vitro fertilised human egg in 1976, modern endocrinology, genetics, and assisted reproductive technologies have opened new frontiers of research with the aim to treat infertile women. In this workshop we set out to promote an interdisciplinary discussion between experts from various fields of basic, company-based and clinical research related to folliculogenesis and oocyte development. The aim of this workshop was to present, discuss and assess novel approaches in mammalian folliculogenesis and oocyte development that may have an impact on fertility/ infertility in the near or distant future. Key issues were the understanding of new modulators of folliculogenesis and regulators of cytoplasmic as well as meiotic oocyte maturation, modern technologies, the aging oocyte and pathogenetic mechanisms of infertility.

Table of Contents

Hormonal Control of Folliculogenesis: The Key to Successful Reproduction	1	(10)
D.T. Baird
A. Mitchell
Activation of Primordial Follicles	11	(12)
J.E. Fortune
Follicular Development and Apoptosis	23	(20)
H. Billig
E. Markstrom
E.C. Sevensson
R. Shao
A. Friberg
Delivery of the Oocyte from the Follicle to the Oviduct: A Time of Vulnerability	43	(20)
J.S.Richards
Phenotypic Effects of Knockout of Oocyte-Specific Genes	63	(18)
S. Varani
M.M. Matzuk
The Biochemistry of Oocyte Maturation	81	(20)
S.M. Downs
The Structural Basis of Oocyte-Granulosa Cell Communication	101	(10)
D.F. Albertini
Ageing and Aneuploidy in Oocytes	111	(26)
U. Eichenlaub-Ritter
Ovarian Infertility - Reasons and Treatment Paradigms	137	(24)
M. Ludwig
K. Diedrich
Can Stimulation Protocols Improve Oocyte Quality?	161	(16)
J. Smitz
FF-MAS and Its Role in Mammaliam Oocyte Maturation	177	(18)
C. Grøndahl
Subject Index	195	(2)
Previous Volumes Published in This Series	197