Genetic Susceptibility to Infectious Diseases

by Kaslow, Richard A.; McNicholl, Janet; Hill, Adrian V. S.

• ISBN13: 9780195174908
• ISBN10: 0195174909
• Format: Hardcover
• Copyright: 2008-03-03
• Publisher: Oxford University Press

Summary

Infectious diseases are commonly regarded as a distinct category, withdifferent causes and patterns than chronic or genetic disease. But in fact thereare many varieties of genetic susceptibility to infection, the subject of thisbook, which will be divided into three sections: 1) concepts and methods, 2)genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. Nocurrently plubished text on either genetics or infectious diseases focuses onthe genetic aspects of the special relationship between host and pathogen in theway envisioned for Section 1. No other work on the selected genes regulatingimmunity deals as systematically with the sequence variation/functionrelationships most pertinent to infection as planned for Section 2. And no otherbook gives as meaningful a picture of how these genes operate in infectiousdisease as Section 3 will.

Table of Contents

Methods and Tools
Genetic Epidemiology of Infectious Disease	p. 3
Laboratory Analysis of Genetic Variation	p. 18
Mouse Models for Genetic Susceptibility to Infection in Humans	p. 32
Immune Response Genes and Infection
MHC Class I and Related Genes	p. 47
MHC Class II and Related Genes	p. 62
MHC Class I Polypeptide-Related Sequence A and B (MICA and MICB) Genes	p. 83
Killer Immunoglobulin-Like Receptor and Related Genes	p. 89
Red Blood Cell Genes and Malaria	p. 107
Immunoglobulin (Fc) and Related Receptor Genes	p. 120
Mannose-Binding Lectin Genes	p. 137
Complement Genes	p. 151
Toll-Like Receptor Genes	p. 165
Metal Transport Genes	p. 175
Tumor Necrosis Factor and Related Genes	p. 190
Cytokine Genes I: IL10, IL6, IL4, and the IL1 Family	p. 208
Cytokine Genes II: IL12, IFNG, and Their Receptor Genes	p. 227
Chemokine Receptor and Ligand Genes	p. 247
Genetic Determinants of Infectious Diseases and Response to Vaccines
Immune Deficicncy Disorders	p. 265
Human Inununodeficiency Virus Type I (HIV-I) and Acquired Immunodeficiency Syndrorne (AIDS)	p. 282
Human T-Lymphotropic Virus Type I (HTLV-1)-Associated Diseases	p. 303
Hepatitis Band Hepatitis C Injection	p. 318
Tuberculosis, Leprosy, and Other Mycobacterial Diseases	p. 333
Diseases Due to Encapsulated Bacteria	p. 351
Malaria	p. 372
Leishmaniasis	p. 387
Schistosomiasis	p. 403
Genetics and Immune Response to Vaccines	p. 414
Selected Useful Web Sites	p. 431
Glossary	p. 433
Index	p. 437
Table of Contents provided by Blackwell. All Rights Reserved.