Genomics and Proteomics in Nutrition

by Berdanier; Carolyn D.

• ISBN13: 9780824754303
• ISBN10: 0824754301
• Format: Hardcover
• Copyright: 2004-08-11
• Publisher: CRC Press

Summary

With contributions from 66 world-renowned authorities on the subject, Genomics And Proteomics In Nutritionfocuses on the effect of genetic expression on protein production, establishing links between gene expression and nutrition, the influence of micro- and macronutrients on cellular homeostasis, and the relationship between diet, genetic predisposition, and human disease. Shows how bioinformatics and functional genomic databases can transform molecular biology research using a yeast ELO2/ human HELO1 protein cloning example. A cutting-edge reference, Genomics and Proteomics in Nutrition reveals new applications and insights in nutrition science and explores tools for nutrition research in the post-genomic era.

Table of Contents

Preface	iii
Contributors	ix
PART I: MOUSE MODELS OF HUMAN DISEASES AND GENE TRANSCIPTION
1. Genetic Modifiers in Rodent Models of Obesity	1	(16)
Yun Wang, Patsy M. Nishina, and Jürgen K. Naggert
2. Quantitative Trait Loci in Obesity and Type II Diabetes in Rodents	17	(34)
Jung Han Kim
3. The Human Sweet Tooth and Its Relationship to Obesity	51	(20)
Amanda H. McDaniel and Danielle R. Reed
4. The Adipose Renin-Angiotensin System: Genetics, Regulation, and Physiologic Function	71	(20)
Brynn H. Voy, Suyeon Kim, Sumithra Urs, Melissa Derfus, Young-Ran Heo, Rashika Joshi, Florence Massiera, Michele Teboul, Gerard Ailhaud, Annie Quignard-Boulangé, and Naima Moustaid-Moussa
5. Regulation of Fat Synthesis and Adipogenesis	91	(28)
Kee-Hong Kim, Michael J. Griffin, Josep A. Villena, and Hei Sook Sul
6. Transcriptional Regulation of Energy Metabolism in Liver	119	(26)
Manabu T. Nakamura
PART II: GENOMICS: LARGE-SCALE ANALYSIS OF GENE EXPRESSION BY MICROARRAY
7. Design and Analysis of Microarray Studies for Obesity Research	145	(60)
Marie-Pierre St-Onge, Steven B. Hy-msfield, Grier P. Page, Kui Zhang, Kyoungmi Kim, Maria DeLuca, and David B. Allison
8. Solving Clinical Problems in Nutrition Research with Microarrays	205	(32)
Steven R. Smith, Andrey Ptitsyn, Dawn M. Graunke, Hui Xie, and Robert A. Koza
9. Genomic Approaches to Understanding Vitamin D Action	237	(20)
James C. Fleet
10. Gene Expression Profiling in Adipose Tissue	257	(24)
Naima Moustaid-Moussa, Sumithra Urs, Brett Campbell, Hyoung Yon Kim, Suyeon Kim, Patrick Wortman, Richard Giannone, Bing Zhang, Jay Snoddy, and Brynn H. Voy
11. Phytochemicals and Gene Expression	281	(16)
Orsolya Mezei and Neil F. Shay
12. Gene Expression Profiling of Immune Cells: Application for Understanding Aging of Immune Cells	297	(20)
Sung Nim Han and Simin Nikbin Meydani
13. Improving the Nutritional Value of Cereal Grains Using a Genomic Approach	317	(14)
Liang Shi and Tong Zhu
PART III: PROTEOMICS: LARGE-SCALE ANALYSIS OF PROTEIN EXPRESSION AND REGULATION
14. Proteomics and Genomics to Detail Responses to Extracellular Stimuli	331	(24)
James A. Carroll and Clayton E. Mathews
15. 2D Gel Proteomics Studies on Leukocytes	355	(20)
Ivan C. Gerling and Michael J. Pabst
16. Proteomics: Tools for Nutrition Research in the Postgenomic Era	375	(20)
Arthur Grider
17. Proteomic Analysis of the Adipocyte Secretome	395	(20)
Nieves Ibarrola, Akhilesh Pandey, and Chaerkady Raghothama
18. Mass Spectrometry Strategies for Proteomic Studies	415	(34)
Maya Belghazi and Helene Rogniaux
19. Bioinformatics Tools	449	(24)
Simon M. Lin, Kimberly F. Johnson, and Seth W. Kullman
20. Statistical Principles for Analysis of Array Experiments	473	(20)
Arnold M. Saxton and E. Barry Moser
Index	493