Glutamate and Addiction

by Herman, Barbara H.; Frankenheim, Jerry; Litten, Raye; Sheriden, Philip H.; Weight, Forrest F.

• ISBN13: 9780896038790
• ISBN10: 0896038793
• Format: Hardcover
• Copyright: 2002-09-01
• Publisher: Humana Pr Inc

Summary

In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states.

Table of Contents

Preface	vii
Contributors	xv
I. Introduction: Physiology and Pharmacology of Glutamate
Philip H. Sheridan
Forrest F. Weight
Barbara H. Herman
Molecular Pharmacology and Physiology of Glutamate Receptors	3	(20)
Karin Borges
Raymond Dingledine
Pharmacology of Glutamate Receptor's	23	(28)
Jeffrey M. Witkin
Rafal Kaminski
Michael A. Rogawski
Glutamate and Neurotoxicity	51	(12)
B. Joy Snider
Dennis W. Choi
Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity	63	(8)
Russell M. Sanchez
Frances E. Jensen
Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia	71	(12)
Marcus Kaul
Stuart A. Lipton
II. Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine)
Jerry Frankenheim
Barbara H. Herman
Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity	83	(24)
Agu Pert
Robert M. Post
Susan R. B. Weiss
Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced Stereotypy and Behavioral Sensitization	107	(20)
Ralph Karler
David K. Thai
Larry D. Calder
Addiction and Glutamate-Dependent Plasticity	127	(16)
Marina E. Wolf
Glutamate and Dopamine Interactions in the Motive Circuit: Implications for Craving	143	(14)
David A. Baker
Jennifer L. Cornish
Peter W. Kalivas
Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication	157	(14)
John Q. Wang
Limin Mao
Yuen-Sum Lau
Glutamate Neurotransmission in the Course of Cocaine Addiction	171	(12)
Luigi Pulvirenti
Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs	183	(18)
Paul Vezina
Nobuyoshi Suto
Roles of Glutamate, Nitric Oxide, Oxidative Stress, and Apoptosis in the Neurotoxicity of Methamphetamine	201	(10)
Jean Lud Cadet
Methamphetamine Toxicity: Roles for Glutamate, Oxidative Processes, and Metabolic Stress	211	(18)
Kristan B. Burrows
Bryan K. Yamamoto
Nitric Oxide-Dependent Processes in the Action of Psychostimulants	229	(14)
Yossef Itzhak
Julio L. Martin
Syed F. Ali
Effects of Novel NMDA/Glycine-Site Antagonists on the Blockade of Cocaine-Induced Behavioral Toxicity in Mice	243	(18)
Rae R. Matsumoto
Buddy Pouw
Clinical Studies Using NMDA Receptor Antagonists in Cocaine and Opioid Dependence	261	(10)
Adam Bisaga
Marian W. Fischman
The Role of mGluR5 in the Effects of Cocaine: Implications for Medication Development	271	(10)
Mark P. Epping-Jordan
III. Glutamate and Opiate Drugs (Heroin) of Abuse
Barbara H. Herman
Jerry Frankenheim
Role of the Glutamatergic System in Opioid Tolerance and Dependence: Effects of NMDA Receptor Antagonists	281	(14)
Jianren Mao
The Role of NMDA Receptors in Opiate Tolerance, Sensitization, and Physical Dependence: A Review of the Research, A Cellular Model, and Implications for the Treatment of Pain and Addiction	295	(28)
Keith A. Trujillo
Modification of Conditioned Reward by N-Methyl-D-aspartate Receptor Antagonists	323	(6)
Piotr Popik
Morphine Withdrawal as a State of Glutamate Hyperactivity: The Effects of Glutamate Receptor Subtype Ligands on Morphine Withdrawal Symptoms	329	(14)
Kurt Rasmussen
IV. Glutamate and Alcohol Abuse and Alcoholism
Forrest F. Weight
Raye Z. Litten
Alcohol Actions on Glutamate Receptors	343	(14)
Robert W. Peoples
Glutamate and Alcohol-Induced Neurotoxicity	357	(18)
Fulton T. Crews
Joseph G. Rudolph
L. Judson Chandler
Role of Glutamate in Alcohol Withdrawal Kindling	375	(14)
Howard C. Becker
Nicole Redmond
Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment	389	(10)
John H. Krystal
Ismene L. Petrakis
D. Cyril D'Souza
Graeme Mason
Louis Trevisan
Mechanism of Action of Acamprosate Focusing on the Glutamatergic System	399	(10)
W. Zieglgansberger
G. Rammes
R. Spanagel
W. Danysz
Ch. Parsons
The NMDA/Nitric Oxide Synthase Cascade in Opioid Analgesia and Tolerance	409	(8)
Gavril W. Pasternak
Yuri Kolesnikov
Overview of Clinical Studies for Acamprosate	417	(10)
Adriaan S. Potgieter
Index	427