Growth, Proliferation, and Apoptosis in Hepatocytes

by Okita, K.

• ISBN13: 9784431703235
• ISBN10: 4431703233
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-11-01
• Publisher: SPRINGER

Summary

To gain a better understanding of the pathology of liver disease, the signaling system controlling hepatocyte differentiation, proliferation, and apoptosis was selected as the theme of the 12th Yamaguchi Symposium on Liver Diseases. Ten leading researchers presented their latest experimental results. Focusing on apoptosis, guest speaker Professor D.A. Brenner, USA, spoke on the regulation of tumor necrosis factor alpha and Fas ligand-induced hepatic apoptosis by nerve factor-kappa B. Other researchers covered the molecular basis for clonal deletion therapy in hepatocellular carcinoma, hepatitis C virus induction of proliferation signals, helix-loop-helix protein in liver-specific gene expression, and reconstitution of hepatic tissues using liver stem cells, among other topics of current interest. These proceedings thus serve as a useful resource for all involved in hepatology research.

Table of Contents

Preface	v
List of Participants	ix
HHM: A Dominant Inhibitory Helix-Loop-Helix Protein Associated with Liver-Specific Gene Expression and Liver Stem Cells	1	(10)
S. Terai
S.S. Thorgeirsson
K. Okita
Expression of Musashi-1 Antigen, A Neural Stem Cell RNA-Binding Protein, in the Liver Tissues of Patients with Hepatitis	11	(8)
T. Saito
H. Mitsui
H. Watanabe
Y. Terui
T. Takeda
M. Aoki
K. Saito
R. Nagashima
H. Takeda
H. Misawa
H. Togashi
M. Yamakawa
S. Kawata
Reconstitution of Hepatic Tissues Using Liver Stem Cells	19	(8)
T. Sugiyama
K. Terada
Regulation of TNF-α- and Fas-Induced Hepatic Apoptosis by NF-KB	27	(6)
D.A. Brenner
E. Hatano
C. Bradham
R. Schwabe
Y. Iimuro
T. Qian
R. Thurman
J. Lemasters
Retinoid-Induced Apoptosis in Hepatocellular Carcinoma: A Molecular Basis for ``Clonal Deletion''. Therapy	33	(8)
M. Okuno
H. Moriwaki
R. Matsushima-Nishiwaki
T. Sano
S. Adachi
K. Akita
S. Kojima
Signal Transduction Involved in Cell Cycle Regulation of Normal Hepatocyte and Hepatoma Cells	41	(12)
Y. Sasaki
M. Horimoto
N. Hayashi
Effects Of Simultaneous Treatment with Growth Factors on DNA Synthesis, MAPK Activity, and G1 Cyclins In Rat Hepatocytes	53	(8)
A. Ido
A. Moriuchi
S. Hirono
H. Tsubouchi
Involvement of p21WAFL/CIPL and p27KIPL in Troglitazone-Induced Cell Cycle Arrest in Human Hepatoma Cell Lines	61	(12)
H. Koga
M. Sata
Role of Fas Ligand in Immunopathogenesis of Hepatocellular Carcinoma	73	(8)
Y. Nakamoto
S. Kaneko
F.V. Chisari
T. Suda
K. Kobayashi
Induction of Proliferation-Related Signals by Hepatitis C Virus	81	(18)
N. Kato
H. Yoshida
M. Otsuka
Y. Shiratori
M. Omata
Subject Index	99