Gut-Liver Interactions

by Blumberg, Richard S.; Gangl, A.; Manns, M. P.; Tilg, H.; Zeitz, M.

• ISBN13: 9781402041433
• ISBN10: 1402041438
• Format: Hardcover
• Copyright: 2005-12-16
• Publisher: Kluwer Academic Pub

Summary

This book, the proceedings of the Falk Symposium No. 146 'Gut-Liver Interactions: Basic and Clinical Concepts', held in Innsbruck, Austria, on March 11-12, 2005, brings together gastroenterologists and hepatologists both at a clinical and a basic scientific level. Topics have been structured in such a way to be of interest to both clinicians and basic scientists. The main focus of the book is to highlight the role of the immune system in gut and liver diseases and potential interactions of the gut and the liver respectively. Special emphasis is based on the importance of the gut flora in intestinal and also in liver diseases. The role of NOD2 is one of the very best examples demonstrating the importance, not only in inflammatory bowel diseases, but also diseases well beyond this barrier.Such intense interactions between gastroenterologists and hepatologists, as shown through this book, might boost and stimulate scientific ideas and research in other unexpected areas.

Table of Contents

List of principal contributors	ix
List of chairpersons	xiii
Preface	xv
SECTION I: GENETICS AND IMMUNOLOGY IN INFLAMMATORY BOWEL DISEASES
D Rachmilewitz
M Zeitz
Inflammatory bowel disease genotypes and phenotypes	3	(12)
R lacob
GV Massouille
J-F Colombel
Abnormalities of Cytokine regulation in the inflammatory bowel diseases	15	(10)
W. Strober
PJ Mannon
IJ Fuss
Dendritic cells -- key players in inflammatory bowel disease	25	(11)
A Kaser
Lipids and inflammatory bowel disease: microsomal triglyceride transfer protein -- the new dimension?	36	(10)
A Kaser
S Betz
S Brozovic
T Nagaishi
M Yoshida
N Corazza
S Colgan
S Young
M Exley
RS Blumberg
The intestinal epithelium and inflammatory bowel disease	46	(7)
DK Podolsky
SECTION II: EVIDENCE-BASED TREATMENT IN INFLAMMATORY BOWEL DISEASES
UR Folsch
A Gangl
Evidence-based therapy with aminosalicylates	53	(9)
W Reinisch
The practical use of steroids in inflammatory bowel disease	62	(5)
G D Haens
Immunosuppressants: clinical use and molecular mechanism of action	67	(4)
MF Neurath
B Weigmann
Biologicals: old and new ones	71	(10)
P Rutgeerts
S Vermeire
G Van Assche
SECTION III: DIFFICULT CASES IN INFLAMMATORY BOWEL DISEASES
P Knoflach
W Kruis
Management of extraintestinal disease in inflammatory bowel disease	81	(22)
J Scholmerich
SECTION IV: INNATE IMMUNITY -- MICROBIAL PRODUCTS
RS Blumberg
S Schreiber
Immunomodulatory properties of the gut microflora	103	(10)
RB Sartor
Defensis and other antimicrobial mediators	113	(9)
CL Bevins
State of the art lecture: Post-infectious irritable bowel syndrome: role of inflammation and gut flora	122	(11)
R Spiller
SECTION V: GUT-LIVER INTERACTIONS -- BASIC AND CLINICAL ASPECTS
G Krejs
MP Manns
The liver and its contribution to induction of oral tolerance	133	(8)
PA Knolle
A Limmer
Molecular regulation of lymphocyte homing between the liver and the gut	141	(12)
B Eksteen
A Miles
A Grant
DH Adams
Modern concepts of coeliac disease pathogenesis	153	(12)
D Schuppan
T Freitag
Hepatobiliary manifestations in inflammatory bowel disease	165	(14)
F Freudenberg
MC Carey
SECTION VI: PRIMARY BILIARY CIRRHOSIS, CHOLESTASIS AND AUTOIMMUNE LIVER DISEASE
H Denk
G Paumgartner
Primary biliary cirrhosis and biliary destruction: 2005; a liver odyssey	179	(12)
S Oertelt
C Selmi
P Invernizzi
M Podda
RL Coppel
ME Gershwin
Primary biliary cirrhosis: clinical aspects	191	(4)
R Poupon
Molecular mechanisms of cholestasis	195	(14)
M Trauner
P Fickert
E Halilbasic
M Wagner
G Zollner
SECTION VII: PRIMARY SCLEROSING CHOLANGITIS, ALCOHOLIC STEATOHEPATITIS, NON-ALCOHOLIC STEATOHEPATITIS
D Schuppan
H Tilg
Basic concepts in primary sclerosing cholangitis: what can we learn from studies of its genetic basis	209	(12)
P Donaldson
Clinical concepts in primary sclerosing cholangitis	221	(20)
U Broome
A Bergquist
Alcoholic liver diseases	241	(8)
CP Day
Should non-alcoholic fatty liver disease be treated differently in elderly patients?	249	(4)
A Suzuki
AM Diehl
SECTION VIII: LIVER FAILURE AND TRANSPLANTATION
I Graziadei
F Muhlbacher
Acute liver failure -- mechanisms of liver cell destruction	253	(11)
C Trautwein
C Liedtke
KLS Streetz
T Luedde
C Klein
Clinical management of acute liver failure	264	(7)
R Williams
Liver and bowel transplantation in 2005	271	(7)
R Margreiter
State-of-the-art-lecture: Established and novel methods for treating inflammatory diseases by inhibition of cytokines	278	(13)
CA Dinarello
Index	291