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9781439819937

Handbook of Analysis of Oligonucleotides and Related Products

by ;
  • ISBN13:

    9781439819937

  • ISBN10:

    1439819939

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2011-02-23
  • Publisher: CRC Press

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Summary

A first-of-its-kind handbook, this text covers all the analytical techniques and methods commonly employed with oligonucleotides. With contributions from experts in the field, this handbook presents comprehensive coverage for analytical chemists, biochemists, biotechnologists, molecular biologists, and geneticists on the latest analytical technologies currently available. Topics covered include purity determination by HPLC, molecular weight determination, determination of hygroscopicity, analysis of bioburden, and analyses of ionic species by ion chromatography. A chapter on PAT and coverage of bioanalytical techniques is also included, and illustrations of analytical techniques and outputs are presented to aid with comprehension.

Table of Contents

Prefacep. v
Editorsp. vii
Contributorsp. ix
Introductionp. xi
Purity Analysis and Impurities Determination by Reversed-Phase High-Performance Liquid Chromatographyp. 1
Purity Analysis and Impurities Determination by AEX-HPLCp. 47
Purity Analysis and Molecular Weight Determination by Size Exclusion HPLCp. 105
Analysis of Oligonucleotides by Liquid Chromatography and Mass Spectrometryp. 137
Sequence Determination and Confirmation by MS/MS and MALDI-TOFp. 167
Tm Analysis of Oligonucleotidesp. 219
Purity and Content Analysis of Oligonucleotides by Capillary Gel Electrophoresisp. 243
Bioanalysis of Therapeutic Oligonucleotides Using Hybridization-Based Immunoassay Techniquesp. 265
Oligonucleotide Assay and Potencyp. 285
Microbial Analysis: Endotoxin Testingp. 307
Analysis of Residual Solvents by Head Space Gas Chromatographyp. 331
Determination of Extinction Coefficientp. 351
Structural Determination by NMRp. 361
Infrared Analysis of Oligonucleotidesp. 385
Stability Indicating Methods for Oligonucleotide Productsp. 403
Analysis by Hydrophilic Interaction Chromatographyp. 425
Determination of Base Compositionp. 439
Analysis of Metals in Oligonucleotidesp. 453
Regulatory Considerations for the Development of Oligonucleotide Therapeuticsp. 465
Indexp. 487
Table of Contents provided by Ingram. All Rights Reserved.

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