Handbook of Laboratory Animal Science, Volume I, Third Edition: Essential Principles and Practices

by Hau; Jann

• ISBN13: 9781420084559
• ISBN10: 1420084550
• Edition: 3rd
• Format: Hardcover
• Copyright: 2010-12-02
• Publisher: CRC Press

Summary

Now in its third edition, this comprehensive handbook explores the myriad issues surrounding the use of animals in scientific laboratories. Topics in Volume I include the history of animal research, ethical concerns, regulation and legislation, facilities and equipment, genetics, health monitoring, nutrient requirements and feeding schedules, statistical analysis, surgical and non-surgical techniques, and anesthesia. The book also explores alternatives to lab animal use with a discussion of the refinement, reduction, and replacement of animal uses in the life sciences. The book boasts an array of international contributors.

Table of Contents

Preface	p. ix
Editors	p. xi
Contributors	p. xiii
The Contribution of Laboratory Animals to Medical Progress-Past, Present, Future	p. 1
Ethics of Animal Research	p. 21
An Overview of Global Legislation, Regulation, and Policies	p. 39
Assessment of Animal Care and Use Programs and Facilities	p. 65
Education and Training	p. 81
Laboratory Animal Science and Service Organizations	p. 97
Laboratory Animal Allergies and Zoonoses	p. 115
Laboratory Animal Facilities and Equipment for Conventional, Barrier, and Containment Housing Systems	p. 145
Laboratory Animal Genetics and Genetic Quality Control	p. 209
Health Status and Health Monitoring	p. 251
Nutrient Requirements, Experimental Design, Feeding Schedules in Animal Experimentation	p. 307
Impact of the Biotic and Abiotic Environment on Animal Experiments	p. 343
Experimental Design and Statistical Analysis	p. 369
Common Nonsurgical Techniques and Procedures	p. 401
Applications of Radiotelemetry in Small Laboratory Animals	p. 447
Immunization for Production of Antibodies	p. 467
Laboratory Animal Analgesia, Anesthesia, and Euthanasia	p. 485
Welfare Assessment and Humane End Points	p. 535
Surgery: Basic Principles and Procedures	p. 573
Microsurgical Procedures in Experimental Research	p. 597
Postmortem Procedures	p. 613
Alternatives: Refinement, Reduction, and Replacement of Animal Uses in the Life Science	p. 635
Generation and Analysis of Genetically Modified Mice	p. 653
Physiological, Hematological, and Clinical Chemistry Parameters, Including Conversion Factors	p. 667
Index	p. 709
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