Handbook of Tuberculosis Molecular Biology and Biochemistry

by Kaufmann, Stefan H. E.; Rubin, Eric

• ISBN13: 9783527318865
• ISBN10: 3527318860
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-03-03
• Publisher: Wiley-Blackwell

Summary

Tuberculosis (TB), a deadly airborne disease caused by the bacterium Mycobacterium tuberculosis, takes the lives of almost 2 million people each year and is considered to be the most common infectious disease in the world. However, thanks to the efforts of researchers such as the volumes' lead editor, Dr. Stefan H. E. Kaufmann, there have been several recent advances in fighting the disease. Dr. Stefan Kaufmann, the Founding Director of the Max Planck Institute for Infection Biology in Berlin and Professor of Microbiology and Immunology at the Charit_ at the Humboldt University, Berlin, has published more than 600 scientific articles and currently serves as President of the European Federation of Immunological Societies and Chair of the Immunology Division of the American Society of Microbiology. Dr. Kaufmann is considered the world's leading expert in the field of tuberculosis. The Handbook of Tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study. Each volume provides an essential resource to molecular and cell biologists, bacteriologists, immunologists, pathologists and pathophysiologists, clinicians and those working in the pharmaceutical industry and interested in world health. Volume 1: Molecular Biology and Biochemistry highlights the molecular mechanisms of tuberculosis. Volume 2: Immunology and Cell Biology is co-edited by Dr. Warwick Britton, Professor of Medicine at the University of Sydney and head of the Mycobacterial Research Program at the Centenary Institute, Sydney, Australia. It presents the pre-eminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development. Volume 3: Clinics, Diagnostics, Therapy and Epidemiology introduces a comprehensive overview of clinical aspects of tuberculosis, including drug resistance, epidemiological aspects and clinical trials.

Author Biography

Prof. Dr. Stefan H.E. Kaufmann is Founding Director of the Max Planck Institute for Infection Biology, Berlin. He has published more than 600 scientific articles and is member of numerous scientific societies and committees e.g. current President of the European Federation of Immunological Societies, and Chair of the Immunology division of the American Society of Microbiology. He has won numerous prestigious awards including the Scientific Prize of Smith Kline Beecham and the Pettenkofer Prize.

Eric Rubin is Professor of Immunology and Infectious Diseases at the Harvard School of Public Health. He carried out both his MD and PhD work at Tufts University.

Table of Contents

Tuberculosis - Molecular Genetics and Biochemistry: Introduction Biochemistry of the Cell Wall Glycolipids and Polyketides of M. tuberculosis

Physiology of M. tuberculosis Nutrient Transport Iron Uptake by M. tuberculosis Protein Transport PE and PPE Gene Family Members in M. tuberculosis

Virulence/Persistence Mechanisms of M. tuberculosis Genomics Transcriptomics and Transcriptional Regulation Proteomics of M. tuberculosis

Structure Molecular Mechanisms of Dormancy and Resuscitation M. tuberculosis in the Phagosome

Molecular Mechanisms of Drug Resistance of M. tuberculosis Experimental

Genetics of M. tuberculosis Molecular Evolution of Mycobacteria

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