Hematopoietic Stem Cell Transplantation

by Champlin; Richard

• ISBN13: 9780824702731
• ISBN10: 0824702735
• Format: Hardcover
• Copyright: 2000-07-25
• Publisher: CRC Press

Summary

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation summarizes current understanding and development of clinical allogeneic HSC transplantation discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors details detection of bone marrow contamination by tumor cells and removal procedures focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors explores the effects of growth factor administration and leukapheresis on PB stem cell donors shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study, Hematopoietic Stem Cell Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

Table of Contents

Preface	iii
Contributors	ix
Novel Cytokines and Cellular Components
Thrombopoietin: Basic Biology and Clinical Effects	1	(22)
Kenneth Kaushansky
C. Glenn Begley
Preclinical Biology and Potential Clinical Utility of flt3 Ligand	23	(8)
Douglas E. Williams
Stem Cell Factor	31	(16)
Leo Lacerna, Jr.
Russell Basser
C. Glenn Begley
Jeffrey Crawford
George Demetri
Craig H. Moskowitz
Guido Tricot
Andrew Weaver
William P. Sheridan
John A. Glaspy
Cytokine Modulation of Hematopoietic Stem Cell Phenotype	47	(22)
Ahmad-Samer Al-Homsi
Peter J. Quesenberry
Homing and Self-Renewal of Hematopoietic Stem Cells	69	(18)
Anthony D. Ho
Michael Punzel
Stefan Fruehauf
Shiang Huang
Bernhard Palsson
Requirements for Hematopoietic Stem Cell Engraftment and Graft Engineering: Role of Facilitating Cells	87	(24)
Michael Neipp
Christina L. Kaufman
Marianne Bergheim
Beate G. Exner
Suzanne T. Ildstad
Ins and Outs of Hematopoietic Stem Cells: Regulation by Genes and Stromal Cells	111	(14)
Christa E. Muller-Sieburg
Rajeev Soni
Cell-Signaling by Adhesion Receptors in Normal and Leukemic Hematopoiesis	125	(12)
Catherine M. Verfaillie
Yuehua Jiang
Robert C. H. Zhao
Felipe Prosper
Ravi Bhatia
Detection of Infrequent Cells in Blood and Bone Marrow by Flow Cytometry	137	(16)
Leon W. M. M. Terstappen
Animal Models
Human/Sheep Hematopoietic Chimeras	153	(18)
Graca Almeida-Porada
Christopher D. Porada
Nam D. Tran
Joao L. Ascensao
Esmail D. Zanjani
Canine Models for Transplantation and Gene Therapy	171	(24)
Hans-Peter Kiem
Rainer Storb
Murine Model of In Utero Transplantation	195	(28)
Ewa Carrier
CD34+ Selection
CD34 Selection Using Immunomagnetic Beads	223	(16)
Robert A. Preti
Andrew L. Pecora
Tauseef Ahmed
Timothy J. Farley
Autologous and Allogeneic Transplantation with Blood CD34+ Cells: A Pediatric Experience	239	(12)
Yoshifumi Kawano
Yoichi Takaue
Tsutomu Watanabe
Yasuhiro Okamoto
Takanori Abe
Yasuhiro Kuroda
Arata Watanabe
Using Allogeneic Graft Engineering to Improve Long-Term Survival	251	(24)
Stephen J. Noga
Purging
Detection and Significance of Minimal Residual Disease from Solid Tumor Malignancies in Stem Cell Autografts	275	(16)
Amy A. Ross
Stem Cell Isolation with Immunomagnetic Beads and Tumor Cell Contamination	291	(12)
Gunnar Kvalheim
Anne Pharo
Harald Holte
Elisabeth Lenschow
Mengyu Wang
Bjorn Erikstein
Stein Kvaloy
John Magne Nesland
Erlend Smeland
Ex Vivo Expansion
CD34 Cell Culture: Clinical Needs and Applications	303	(18)
Dennis E. Van Epps
Critical Parameters Influencing the Expansion and Differentiation of Cultured Human CD34+ Cells	321	(12)
Jane S. Lebkowski
Lisa R. Schain
Advances in Allogeneic Transplantation
Mobilization of Peripheral Blood Stem Cells from Normal Donors	333	(28)
Thomas A. Lane
Ping Law
Innovative Approaches for Allogeneic Blood and Marrow Transplantation for Treatment of Hematological Malignancies: Graft Engineering and Nonmyeloablative Preparative Regimens	361	(22)
Richard E. Champlin
Peripheral Blood Stem Cells for Allogeneic Transplantation	383	(20)
Lutz Uharek
Peter Dreger
Bertram Glass
Matthias Zeis
Norbert Schmitz
Mechanisms of Cure of Acute Myeloid Leukemia with Allogeneic Transplantation	403	(10)
Frederick R. Appelbaum
Late Complications of Hematopoietic Stem Cell Transplantation	413	(22)
Emin Kansu
Keith M. Sullivan
GVHD, GVL
Prevention of Acute Graft-Versus-Host Disease by Delayed or Selected Lymphocyte Add Back	435	(12)
John Barrett
Dimitrios Mavroudis
Advances in Autologous Transplantation
Blood Stem Cell Versus Bone Marrow Transplantation: A Critical Appraisal	447	(10)
Anne Kessinger
Autologous Peripheral Blood Stem Cell Collection and Engraftment	457	(22)
Stefan Hohaus
Maria Teresa Voso
Simona Martin
Rainer Haas
Stem Cell Transplantation for Hodgkin's Disease	479	(20)
Ram Kancherla
Tauseef Ahmed
Stem Cell Transplantation for Multiple Myeloma-10 Years Later	499	(18)
David S. Siegel
Seah H. Lim
Guido Tricot
K. R. Desikan
A. Fassas
Jayesh Mehta
Seema Singhal
Elias Anaissie
Sundar Jagannath
Barthel Barlogie
High-Dose Therapy for Primary and Metastatic Breast Cancer	517	(20)
Gary Spitzer
Kenneth Meehan
Douglas Adkins
Genetic and Immune Therapy
Gene Therapy Using Hematopoietic Stem Cells	537	(16)
Donald B. Kohn
Gay M. Crooks
Jan A. Nolta
Gene Therapy for Human Immunodeficiency Virus Infection Using Stem Cell Transplantation	553	(16)
Alain Gervaix
Flossie Wong-Staal
Autografting Followed by Low-Intensity Conditioning Regimen for Allografting	569	(6)
Angelo M. Carella
Development of Retroviral Vectors that Target Hematopoietic Stem Cells	575	(20)
Chris A. Benedict
Yi Zhao
Nori Kasahara
Paula M. Cannon
W. French Anderson
Index	595