Hematopoietic Stem Cells VIII

by Kanz, Lothar; Lengerke, Claudia; Fibbe, Willem E.; Dick, John E.

• ISBN13: 9781573318679
• ISBN10: 1573318671
• Edition: 1st
• Format: Paperback
• Copyright: 2012-09-25
• Publisher: Wiley-Blackwell

Summary

This volume stems from the eighth international symposium and workshop entitled "Hematopoietic Stem Cells VIII" held hosted by the University of Tuebingen, Germany in the fall of 2011. The meeting was designed to bring ~30 leading scientists together to discuss the state-of-the-art in the field of hematopoietic stem cells. Topics reviewed in this volume include: differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches; hematopoietic stem cell expansion; TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia; regulatory factors for hematopoietic stem cells; reprogramming factors; immune reconstitution and strategies for rebuilding of the immune system after haploidentical stem cell transplantation; zebrafish xenografts as a tool for in vivo studies on human cancer; enhancing engraftment of cord blood cells; current insights into neutrophil homeostasis; and molecular live cell bioimaging in stem cell research, among others. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Author Biography

Lothar Kanz is a Professor in Hematology, Oncology und Immunology at the University of Tübingen, Tübingen, Germany.

Claudia Lengerke, M.D. is Head of the Laboratory for Developmental Biology, Division of Hematology and Oncology, at the University of Tuebingen Medical Center.

Willem E. Fibbe is a Professor at Leiden University Medical Center, Leiden, the Netherlands.

John E. Dick, PhD is a Senior Scientist in the Division of Cellular & Molecular Biology at Toronto General Research Institute (TGRI), University of Toronto, Toronto, Ontario, Canada.

Table of Contents

Preface for Hematopoietic Stem Cells VIII vii
Claudia Lengerke, Willem E. Fibbe, John E. Dick, and Lothar Kanz

Basic aspects of stem cell biology

Epigenetic differences between sister chromatids? 1
Peter M. Lansdorp, Ester Falconer, Jiang Tao, Julie Brind’Amour, and Ulrike Naumann

Reprogramming cell fates: insights from combinatorial approaches 7
Carlos-Filipe Pereira, Ihor R. Lemischka, and Kateri Moore

Molecular live cell bioimaging in stem cell research 18
Max Endele and Timm Schroeder

The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems 28
Stefan Tümpel and K. Lenhard Rudolph

Hematopoietic stem cell development and molecular regulation

In vivo divisional tracking of hematopoietic stem cells 40
Hitoshi Takizawa and Markus G. Manz

Caudal genes in blood development and leukemia 47
Claudia Lengerke and George Q. Daley

Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche 55
Kenichi Miharada, Göran Karlsson, Matilda Rehn, Emma Rörby, Kavitha Siva, Jörg Cammenga, and Stefan Karlsson

G protein-coupled receptor crosstalk and signaling in hematopoietic stem and progenitor cells 63
Robert Möhle and Adriana C. Drost

Molecular and functional characterization of early human hematopoiesis 68
Elisa Laurenti and John E. Dick

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche 72
Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Yoshiko Matsumoto, and Toshio Suda

Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches 78
Paul P.C. Roozen, Martijn H. Brugman, and Frank J.T. Staal

Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets 94
Kavitha Sivasubramaniyan, Daniela Lehnen, Roshanak Ghazanfari, Malgorzata Sobiesiak, Abhishek Harichandan, Elisabeth Mortha, Neli Petkova, Sabrina Grimm, Flavianna Cerabona, Peter de Zwart, Harald Abele, Wilhelm K. Aicher, Christoph Faul, Lothar Kanz, and Hans-Jörg Bühring

Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders 107
Maria Ester Bernardo and Willem E. Fibbe

Stem cells and cancer

TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia 118
Yoshikane Kikushige and Koichi Akashi

Zebrafish xenografts as a tool for in vivo studies on human cancer 124
Martina Konantz, Tugce B. Balci, Udo F. Hartwig, Graham Dellaire, Maya C. André, Jason N. Berman, and Claudia Lengerke

Translational research

Hematopoietic stem cell expansion: challenges and opportunities 138
Marta A. Walasek, Ronald van Os, and Gerald de Haan

Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function 151

Hal E. Broxmeyer

Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation 161
Lena Oevermann, Peter Lang, Tobias Feuchtinger, Michael Schumm, Heiko-Manuel Teltschik, Patrick Schlegel, and Rupert Handgretinger

Current insights into neutrophil homeostasis 171
Stefanie Bugl, Stefan Wirths, Martin R. Müller, Markus P. Radsak, and Hans-Georg Kopp

Prospects and challenges of induced pluripotent stem cells as a source of hematopoietic stem cells 179
Dirk W. van Bekkum and Harald M.M. Mikkers