A History of Nerve Functions: From Animal Spirits to Molecular Mechanisms

by Sidney Ochs

• ISBN13: 9780521247429
• ISBN10: 052124742X
• Edition: 1st
• Format: Hardcover
• Copyright: 2004-04-19
• Publisher: Cambridge University Press

Summary

Recent developments have extended our knowledge of the basic functions of nerves: notably, the demonstration of the mechanism within nerve fibers which transports a wide range of essential materials. In order to understand how this discovery occurred, it is necessary to examine its history. The story begins in ancient Greece when nerves were conceived of as channels through which animal spirits carried sensory impressions to the brain. As science developed, the discoveries of various physical and chemical agents supplanted the agency of animal spirits until the molecular machinery of transport was recognized. In this fascinating and complete history, Sidney Ochs begins with a chronological look at this path of discovery, followed in the second half by a thematic approach wherein the author describes the electrical nature of the nerve impulse, fiber form and its changes in degeneration and regeneration, reflexes, learning, memory and other higher functions in which transport participates.

Table of Contents

1. Introduction: Greek science and the recognition of nerves' function

2. Galen's physiology of the nervous system

3. Nerve, brain, and soul in the Middle Ages

4. Renaissance and the New Physiology

5. New physical and chemical models of nerve in the Enlightenment

6. New systematizations of nerve function in the Enlightenment

7. Electricity as the Agent of Nerve Action

8. Nerve fiber form and transformation

9. Wallerian degeneration: early and late phases

10. Nerve regeneration

11. Characterization of axoplasmic transport

12. Molecular models of transport

13. Actions of neurotoxins and neuropathic changes related to transport

14. Purposeful reflexes and instinctive behavior

15. Neural events related to learning and memory

16. Epilogue

Bibliography.