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Cystic Fibrosis 4E provides everything that the respiratory clinician, pulmonologist or health professional treating patients with cystic fibrosis will need in a single manageable volume. This international and authoritative work brings together current knowledge, and has become established in previous editions as a leading reference in the field.The basic science that underlies the disease and its progression is outlined in detail and put into a clinical context. Diagnostic and clinical aspects are covered in depth and future developments, including gene therapies and novel therapies, are covered in the concluding section. Drawing on the expertise of a team of international specialists from a variety of backgrounds,the fourth edition of Cystic Fibrosis is an invaluable reference for respiratory physicians, pediatricians, specialist nurses and other health professionals working with patients with cystic fibrosis. * Divided into accessible sections reflecting the multi-disciplinary nature ofthe cystic fibrosis care team * Expanded coverage of clinical areas, including chapters covering sleep, lung mechanics and the work of breathing, upper airway disease, insulin deficiency and diabetes, bone disease, and sexual and reproductive issues * Covers management in the hospital and at home * New section on monitoring discusses the use of databases to improve patient care, and covers monitoring in different age groups, exercise testing and the outcomes of clinical trials in these areas. * Chapters devoted to paramedical issues, including nursing, physiotherapy,psychology, and palliative and spiritual care New for the fourth edition Many new chapters including: Living with Cystic Fibrosis, Growing Old with Cystic Fibrosis, Quality Improvement and Outcome of Clinical Trials Much more information on: Animal models, Infecttion and Inflammation of the airway affected by cystic fibrosis, Management of the screened patient and Pulmonary exacerbations A new expert and authoritative editorial team with many new international contributors provide a trusted source of information E book containing many more references, links to pub med, rapid search function, more illustrations and clinical photographs and extra video clips Newly designed for rapid access to information at a glance.