HPV and Other Infectious Agents in Cancer Opportunities for Prevention and Public Health

by Krueger, Hans; Stuart, Gavin; Gallagher, Richard; Williams, Dan; Kerner, Jon

• ISBN13: 9780199732913
• ISBN10: 0199732914
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-04-12
• Publisher: Oxford University Press

Summary

After considering the aging population in developed countries, it has become clear to physicians and public policy administrators that prevention of cancer must play a more important role in national anti-cancer policy than it has in the past. The recent introduction of an HPV vaccine, coupled with discoveries concerning the relationship of H. pylori and cancer has brought the role of infectious agents in cancer into sharp focus in the medical community. While interest in the subject has grown, no single source existed to bring clinicians up-to-date on developments in disease mechanisms, population-based risk assessment and policy considerations in the field of cancer prevention. In this current and comprehensive text the authors review the basic science and clinical implications of individual infectious agents, while going beyond a mere update of the literature to offer insights on the current emerging prevention possibilities. This prevention perspective is what makes this particular text so valuable to researchers, epidemiologists, health care policy makers and oncologists. The discussion is organized to highlight the vital role of primary cancer prevention, and suggest directions for future research, practice and policy. Since HPV continues to be at the center of interest in the arena of infectious agents and cancer, the authors frame the majority of their discussion on this now-famous virus. The sheer volume of literature related to this virus and its many related cancers, and the burgeoning research on the development and implementation of a prophylactic vaccine necessitates a much fuller review of this infectious agent. Therefore, the book is roughly divided into two equal parts: one part devoted to HPV and another part devoted to five other prominent infectious agents in cancer.

Author Biography

Hans Krueger, PhD, is a scientist whose firm does research, risk assessment, and consulting for anti-cancer agencies and government across Canada. He holds an appointment I the Dept. of Health Care and Epidemiology at the University of BC, Vancouver
Gavin Stuart, MD is a Gynaecologic Oncologist and the Dean of the Faculty of Medicine at the University of British Columbia in Vancouver
Richard Gallangher, MD, is Head of the Cancer Control Research Program at the British Columbia Cancer Agency and a Clinical Professor in the School of Population and Public Health at the University of British Columbia in Vancouver
Dan Williams is a research associate with Hans Kruegar and Associates in Vancouver
Jon Kerner, PhD, is Chair of the Primary Prevention Action Group for the Canadian Partnership Against Cancer in Toronto

Table of Contents

Introduction-Infection and Cancer: An Expanding Paradigm	p. 3
Human Papillomavirus: Structure, Transmission, and Occurrence	p. 21
Human Papillomavirus: Infection, Natural History, and Carcinogenesis	p. 57
Human Papillomavirus: Associations with Cervical Cancer	p. 79
Human Papillomavirus: Associations with Noncervical Cancer	p. 129
Human Papillomavirus: Detection of Infection and Disease	p. 213
Human Papillomavirus: Prevention of Infection and Disease	p. 259
Hepatitis Viruses	p. 287
Helicobacter pylori	p. 341
Epstein-Barr Virus	p. 385
Human Herpesvirus Type 8	p. 429
Human T-cell Lymphotropic Virus Type 1	p. 471
Conclusion-Infection and Cancer: A Paradigm Shift	p. 505
Index	p. 537
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