Hughes Syndrome

by Khamashta, Munther A.

• ISBN13: 9781852338732
• ISBN10: 1852338733
• Edition: 2nd
• Format: Hardcover
• Copyright: 2006-02-28
• Publisher: Springer Verlag

Summary

The revised second edition addresses the complete range of conditions produced by this common disorder also known as APS or "sticky blood" syndrome. APS is one of the main causes of strokes (40%), leg deep vein thrombosis, and recurrent miscarriages in women. It is an important risk factor for thrombosis in women taking the oral contraceptive pill.The effects of this syndrome were found initially in thrombosis, obstetrics (APS is the commonest treatable cause of recurrent pregnancy loss) and neurology. Its impact is now felt in a diverse range of conditions, including surgery (graft rejection), orthopedics (avascular necrosis, DVT), psychiatry (memory loss), cardiology (pulmonary hypertension, valvular disease, angina), ENT (vertigo), and pediatrics (young strokes, epilepsy).Described as one of the major new diseases of the late 20th century, APS is a multi-specialty disease and is of increasing interest to obstetricians, rheumatologists, hematologists, dermatologists, neurologists and immunologists.

Table of Contents

Section 1: Clinical Aspects
1 Hughes Syndrome: History
Munther A. Khamashta	3	(6)
2 Antiphospholipid (Hughes) Syndrome: An Overview
David P. D'Cruz	9	(13)
3 Epidemiology of Antiphospholipid Syndrome
Michelle Petri	22	(7)
4 Hemocytopenias in Antiphospholipid Syndrome
Carlomaurizio Montecucco and Roberto Caporali	29	(12)
5 Cardiac Manifestations in Antiphospholipid Syndrome
Josep Font and Ricard Cervera	41	(12)
6 Cerebral Ischemia in Antiphospholipid Syndrome
Debendra Pattanaik and Robin L. Brey	53	(15)
7 Cerebral Disease Other than Stroke and Transient Ischemic Attack in Antiphospholipid Syndrome
Giovanni Sanna	68	(18)
8 Skin Manifestations of Antiphospholipid Syndrome
Carlos A. Battagliotti	86	(13)
9 Kidney Disease in Antiphospholipid Syndrome
Mary-Carmen Amigo and Romeo Garcia-Torres	99	(13)
10 Systemic Hypertension in Antiphospholipid Syndrome
Shirish R. Sangle and David P. D'Cruz	112	(5)
11 Pulmonary Hypertension and Antiphospholipid Antibodies
Jean-Charles Piette and Beverley J. Hunt	117	(10)
12 Osteoarticular Manifestations of Antiphospholipid Syndrome
Maria G. Tektonidou and Haralampos M. Moutsopoulos	127	(13)
13 The Ear and Antiphospholipid Syndrome
Elias Toubi and Aharon Kessel	140	(7)
14 The Eye in Primary Antiphospholipid Syndrome
Cristina Castalñon and Pedro A. Reyes	147	(8)
15 Primary Antiphospholipid Syndrome
Tonia L. Vincent and Charles G. Mackworth-Young	155	(16)
16 Catastrophic Antiphospholipid Syndrome
H. Michael Belmont	171	(10)
17 Obstetric Antiphospholipid Syndrome
T. Flint Porter, Robert M. Silver, and D. Ware Branch	181	(15)
18 Infertility and Antiphospholipid Antibodies
Lisa R. Sammaritano	196	(13)
19 Transplantation of Solid Organs, Tissues, and Prosthetic Devices in Patients with Antiphospholipid Antibodies
Dawn R. Wagenknecht and John A. McIntyre	209	(32)
20 Antiphospholipid Syndrome in Children
Lori B. Tucker and Rolando Cimaz	241	(17)
21 Ethnic and Geographic Variation in Antiphospholipid Syndrome
Wendell A. Wilson and Elena Cucurull	258	(6)
22 Antiphospholipid Syndrome: Differential Diagnosis
Beverley Hunt and Paul R.J. Ames	264	(11)
Section 2: Laboratory Investigation
23 Anticardiolipin Testing
Silvia S. Pierangeli	275	(16)
24 Lupus Anticoagulants: Mechanistic and Diagnostic Considerations
Jef M.M.C. Arnout and Jos Vermylen	291	(16)
25 &beta2;-glycoprotein I and Anti-&beta2;glycoprotein I Antibodies
Shinsuke Yasuda, Tatsuya Atsumi, and Takao Koike	307	(12)
26 Antiprothrombin Antibodies
Maria Laura Bertolaccini	319	(10)
27 Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies
Robert A.S. Roubey	329	(12)
Section 3: Basic Aspects
28 Vascular Pathology of Antiphospholipid Antibody Syndrome
Gale A. McCarty	341	(21)
29 Placental Pathology in Antiphospholipid Syndrome
Ann L. Parke	362	(13)
30 Antiphospholipid Syndrome - Experimental Models: Insight into Etiology, Pathogenesis, and Treatments
Miri Blank, Ilan Krause, and Yehuda Shoenfeld	375	(20)
31 Antiphospholipid Antibody-Induced Pregnancy Loss and Thrombosis
Guillermina Girardi and Jane E. Salmon	395	(8)
32 Mechanism of Thrombosis in Antiphospholipid Syndrome: Binding to Platelets
Joan-Caries Reverter and Dolors Tássies	403	(12)
33 Interaction of Antiphospholipid Antibodies with Endothelial Cells
Pier Luigi Meroni, Elena Raschi, Cinzia Testoni, Arianna Parisio, Maria Gerosa, and Maria Orietta Borghi	415	(12)
34 The Influence of Antiphospholipid Antibodies on the Protein C Pathway
Philip G. de Groot and Ronald H.W.M. Derksen	427	(12)
35 Contribution of Tissue Factor to the Pathogenesis of Thrombosis in Patients with Antiphospholipid Syndrome
Chary López-Pedrera, Francisco Velasco, and Maria J. Cuadrado	439	(7)
36 Annexins in Antiphospholipid Syndrome
Jacob H. Rand and Xiao-Xuan Wu	446	(11)
37 Plasminogen Activation, Fibrinolysis, and Cell Proteolytic Activity in Antiphospholipid Syndrome
Eduardo Anglés-Cano	457	(13)
38 Lessons from Sequence Analysis of Monoclonal Antiphospholipid Antibodies
Ian P. Giles, David A. Isenberg, and Anisur Rahman	470	(22)
39 Apoptosis and Antiphospholipid Antibodies
Keith B. Elkon, Neelufar Mozaffarian, and Natalia Tishkevich	492	(9)
40 Accelerated Atherogenesis and Antiphospholipid Antibodies
Eiji Matsuura, Kazuko Kobayashi, and Luis R. Lopez	501	(20)
41 Genetics of Antiphospholipid Syndrome
Tatsuya Atsumi and Olga Amengual	521	(11)
42 Infection and Drug-Induced Antiphospholipid Antibodies
Silvia S. Pierangeli and Azzudin E. Gharavi	532	(15)
Section 4: Therapy
43 Management of Thrombosis in Antiphospholipid Syndrome
Munther A. Khamashta and Guillermo Ruiz-Irastorza	547	(8)
44 Management of Antiphospholipid Syndrome in Pregnancy
Lorin Lakasing, Susan Bewley, and Catherine Nelson-Piercy	555	(13)
45 Management of Thrombocytopenia in Hughes Syndrome
Monica Galli and Tiziano Barbui	568	(11)
46 The Future of Hughes Syndrome
Michael D. Lockshin	579	(4)
Index	583