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Johann Schaller and Simon Gerber are the authors of Human Blood Plasma Proteins: Structure and Function, published by Wiley.
Preface | p. xi |
Introduction | p. 1 |
References | p. 3 |
p. 5 | |
Blood Components | p. 7 |
Introduction | p. 7 |
Short History | p. 7 |
Blood Components | p. 8 |
Blood cells | p. 8 |
Blood plasma | p. 12 |
The blood group system | p. 13 |
References | p. 15 |
Data Sheet | p. 16 |
Blood Plasma Proteins | p. 17 |
Introduction | p. 17 |
Short History | p. 17 |
Classification of Blood Plasma Proteins | p. 17 |
References | p. 20 |
p. 21 | |
Domains, Motifs and Repeats | p. 23 |
Introduction | p. 23 |
The Epidermal Growth Factor (EGF)-Like Domain | p. 24 |
The Kringle Domain | p. 26 |
The [gamma]-Carboxyglutamic Acid-Rich (Gla) Domain | p. 27 |
The PAN/Apple Domain | p. 28 |
The Sushi/CCP/SCR Domain | p. 30 |
The Fibronectin Type I, the Fibronectin Type II Collagen-Binding and the Fibronectin Type III Domains | p. 31 |
The Coagulation Factors 5/8 Type C Domain (FA58C) | p. 32 |
The Thrombospondin Type I Repeat (TSP1) | p. 34 |
The VWFA, VWFC and VWFD Domains | p. 35 |
The Cystatin-Like Domain | p. 36 |
The LDL-Receptor Class A (LDLRA) and Class B (LDLRB) Domains | p. 36 |
The C-Terminal Cystine Knot (CTCK) Structure | p. 38 |
The Anaphylatoxin Domain | p. 40 |
The CUB Domain | p. 40 |
The NTR Domain | p. 41 |
The C-Type Lectin (CTL) Domain | p. 42 |
The Ig-Like Domain | p. 43 |
References | p. 44 |
Protein Families | p. 47 |
Introduction | p. 47 |
Serine Proteases: The Trypsin Family | p. 47 |
Serine Protease Inhibitors (Serpins) | p. 48 |
The [alpha subscript 2]-Macroglobulin Family | p. 50 |
The Serum Albumin Family | p. 52 |
The Pancreatic Trypsin Inhibitor (Kunitz) Family Signature | p. 52 |
The Kazal Serine Protease Inhibitors Family Signature | p. 53 |
The Multicopper Oxidase Family | p. 54 |
The Lipocalin Family | p. 54 |
The Globin Family | p. 55 |
The Glucagon/Gastric Inhibitory Polypeptide (GIP)/Secretin/Vasoactive Intestinal Peptide (VIP) Family | p. 56 |
The Glycoprotein Hormone Family | p. 58 |
Membrane Attack Complex Components/Perforin Signature (The Complement C6/C7/C8/C9 Family) | p. 59 |
The Lipase Family | p. 60 |
Hormone Families and Signatures | p. 61 |
The erythropoietin/thrombopoietin signature | p. 61 |
The corticotropin-releasing factor family | p. 61 |
The gonadotropin-releasing hormone signature | p. 62 |
The calcitonin/CGRP/IAPP family | p. 62 |
The gastrin/cholecystokinin family | p. 62 |
The insulin family | p. 62 |
Growth Factor Families | p. 64 |
The platelet-derived growth factor family | p. 64 |
The transforming growth factor-[beta] family | p. 64 |
Cytokine Families | p. 65 |
The tumor necrosis factor family | p. 65 |
The interferon [alpha], [beta] and [delta] family | p. 66 |
Interleukin Families and Signatures | p. 66 |
The interleukin-1 signature | p. 66 |
The interleukin-2 signature | p. 67 |
The interleukin-4/-13 signature | p. 68 |
The interleukin-6/granulocyte colony-stimulating factor/myelomonocytic growth factor family | p. 68 |
The interleukin-7 and -9 signature | p. 69 |
Interleukin-10 family | p. 69 |
The Small Cytokine (Intercrine/Chemokine) Family and Signature | p. 70 |
References | p. 72 |
Posttranslational Modifications | p. 75 |
Introduction | p. 75 |
Databases for Posttranslational Modifications (PTMs) | p. 75 |
Disulfide Bridges | p. 75 |
Glycosylation | p. 77 |
Phosphorylation | p. 79 |
Ser/Thr phosphorylation sites | p. 80 |
Tyr phosphorylation site | p. 81 |
Hydroxylation | p. 81 |
Aspartic acid and asparagine hydroxylation site | p. 81 |
Sulfation | p. 82 |
Acylation and Alkylation | p. 84 |
Amidation | p. 84 |
Carboxylation | p. 84 |
Crosslinks | p. 85 |
The isoglutamyl cysteine thioester bond | p. 85 |
The isopeptide bond | p. 85 |
References | p. 86 |
p. 89 | |
Blood Coagulation and Fibrinolysis | p. 91 |
Introduction | p. 91 |
Definition of haemostasis | p. 91 |
Primary Haemostasis | p. 92 |
The Coagulation Cascade | p. 95 |
The Fibrinolytic System | p. 109 |
The Regulation of Blood Coagulation and Fibrinolysis | p. 114 |
The Kinin and Angiotensin/Renin Systems | p. 116 |
References | p. 119 |
Data Sheets | p. 121 |
The Complement System | p. 151 |
Introduction | p. 151 |
Nomenclature | p. 152 |
The Classical Pathway | p. 152 |
The anaphylatoxins C3a, C4a and C5a | p. 160 |
The Alternative Pathway | p. 160 |
The Terminal Components of the Complement System | p. 162 |
Components of Complement Activation | p. 165 |
Regulation of the Complement System | p. 167 |
References | p. 171 |
Data Sheets | p. 172 |
The Immune System | p. 195 |
Introduction | p. 195 |
Immunoglobulins | p. 196 |
Antibody Diversity | p. 203 |
Major Histocompatibility Complex (MHC) Proteins | p. 205 |
Innate Immune System | p. 209 |
Other Proteins | p. 213 |
References | p. 214 |
Data Sheets | p. 215 |
Enzymes | p. 231 |
Introduction | p. 231 |
EC 1: Oxidoreductases | p. 231 |
EC 1.11: peroxidases | p. 233 |
EC 2: Transferases | p. 236 |
EC 2.3: acyltransferases | p. 236 |
EC 2.6: transfer of nitrogenous group | p. 237 |
EC 2.7: transfer of phosphorous-containing groups | p. 237 |
EC 3: Hydrolases | p. 239 |
EC 3.1: esterases (ester bond) | p. 239 |
EC 3.2: glycosylases (sugars) | p. 242 |
EC 3.4: peptidases (peptide bonds) | p. 243 |
EC 3.4.17: metallocarboxypeptidases | p. 243 |
EC 3.4.21: serine endopeptidases (serine proteases) | p. 243 |
EC 3.4.22: cysteine endopeptidases (cysteine proteases) | p. 250 |
EC 3.4.23: aspartic endopeptidases (aspartic proteases) | p. 253 |
EC 5: Isomerases | p. 255 |
EC 5.3: oxidoreductases (intramolecular) | p. 256 |
References | p. 257 |
Data Sheets | p. 258 |
Inhibitors | p. 283 |
Introduction | p. 283 |
Serine Protease Inhibitors (Serpins) | p. 283 |
Introduction | p. 283 |
Structural properties | p. 284 |
Inhibitory reaction | p. 286 |
Blood Coagulation and Fibrinolysis | p. 286 |
Blood coagulation | p. 287 |
Fibrinolysis | p. 291 |
The Complement System | p. 292 |
General Inhibitors | p. 293 |
Other Serpins | p. 294 |
Other Inhibitors | p. 294 |
References | p. 298 |
Data Sheets | p. 299 |
Lipoproteins | p. 317 |
Introduction | p. 317 |
Enzymes in Lipoprotein Metabolism | p. 318 |
Apolipoproteins | p. 320 |
LDL and VLDL Receptors | p. 324 |
Serum Amyloid A Proteins | p. 325 |
References | p. 326 |
Data Sheets | p. 327 |
Hormones | p. 343 |
Introduction | p. 343 |
Pancreatic Hormones | p. 343 |
Gastrointestinal Hormones | p. 346 |
Calcium-Related Hormones | p. 347 |
Hormone-Releasing Factors, Their Trophic Hormones and Related Hormones | p. 349 |
Vasopressin and Oxytocin | p. 355 |
Natural Opioid Peptides | p. 356 |
Vasoactive Peptides | p. 357 |
Erythropoietin and Thrombopoietin | p. 359 |
Others | p. 360 |
Adiponectin | p. 360 |
Islet amyloid polypeptide | p. 360 |
References | p. 361 |
Data Sheets | p. 362 |
Cytokines and Growth Factors | p. 393 |
Introduction | p. 393 |
Interleukin Families | p. 395 |
Interleukin-1 family | p. 395 |
Interleukin-2 family | p. 397 |
Interleukin-3 family | p. 397 |
Interleukin-4/interleukin-13 family | p. 398 |
Interleukin-5 family | p. 398 |
Interleukin-6 family | p. 400 |
Interleukin-7/interleukin-9 family | p. 402 |
Interleukin-10 family | p. 402 |
Interleukin-15 family | p. 404 |
Granulocyte-macrophage colony-stimulating factor family | p. 404 |
Tumour Necrosis Factor Family | p. 405 |
The Interferon Family | p. 406 |
The interferon [alpha]/[beta] family | p. 406 |
The interferon [gamma] family | p. 408 |
Chemokines | p. 408 |
The intercrine [alpha]/chemokine CxC family | p. 409 |
The intercrine [beta]/chemokine CC family | p. 410 |
The Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor Family | p. 413 |
Transforming Growth Factor-[beta] Family | p. 414 |
Miscellaneous | p. 415 |
The nerve growth factor-[beta] family | p. 415 |
Epidermal growth factor | p. 417 |
Insulin-like growth factor binding proteins | p. 418 |
References | p. 418 |
Data Sheets | p. 419 |
Transport and Storage | p. 451 |
Introduction | p. 451 |
The Serum Albumin Family | p. 451 |
The Globin Family | p. 452 |
Haptoglobin | p. 456 |
Iron Transport and Storage | p. 457 |
Iron oxidation: ceruloplasmin | p. 457 |
Iron transport proteins: transferrins | p. 459 |
Iron storage | p. 462 |
Heme transport and iron recovery: hemopexin | p. 462 |
Transport of Hormones, Steroids and Vitamins | p. 463 |
Hormone transport proteins | p. 464 |
Steroid transport proteins | p. 467 |
Vitamin A transport protein | p. 467 |
Other Transport Proteins in Plasma | p. 468 |
Selenoproteins | p. 468 |
References | p. 468 |
Data Sheets | p. 469 |
Additional Proteins | p. 487 |
Introduction | p. 487 |
Additional Blood Plasma Proteins | p. 487 |
Data Sheets | p. 492 |
Appendix | p. 503 |
Glossary | p. 515 |
Index | p. 521 |
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