Hybrid SPECT/CT Imaging in Clinical Practice

by Israel; Ora

• ISBN13: 9780824728540
• ISBN10: 0824728548
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-05-22
• Publisher: CRC Press

Summary

Technion-Israel Institute of Technology, Haifa. Presents recent advances and clinical applications of sequential, single session single-photon emission computed tomography and computed tomography imaging. Topics include physics and history of SPECT/CT, clinical applications of SPECT/CT, imaging for prostate cancer, and more. For radiologists.

Table of Contents

Preface	v
Contributors	xiii
PART I: INTRODUCTION AND TECHNICAL ASPECTS
Physics and History of SPECT/CT	1	(24)
Bruce H. Hasegawa
Alex Frenkel
Introduction	1	(1)
Brief History of Dual-Modality Imaging	2	(4)
General Design Features of Dual-Modality Imaging Systems	6	(2)
SPECT/CT Imaging Systems	8	(1)
Capabilities of Dual-Modality Imaging	9	(6)
Need for Dual-Modality Imaging	15	(1)
Challenges of Dual-Modality Imaging	16	(1)
Future of Dual-Modality Imaging	17	(1)
Concluding Remarks	18	(1)
References	19	(6)
PART II: CLINICAL APPLICATIONS OF SPECT/CT IN TUMOR IMAGING
99mTc-Sestamibi SPECT/CT for Parathyroid Imaging	25	(16)
Yodphat Krausz
Introduction	25	(1)
Anatomy	26	(1)
Surgery	26	(1)
Imaging	27	(8)
Conclusion	35	(1)
References	35	(6)
131Iodine SPECT/CT for Thyroid Cancer Imaging	41	(18)
William H. Martin
Dominique Delbeke
Introduction	41	(1)
Differentiated Thyroid Carcinoma	41	(4)
Localization of Recurrent and Metastatic Disease with 131I-SPECT/CT	45	(2)
Other Types of Thyroid Cancers	47	(6)
Summary and Future Directions	53	(1)
References	54	(5)
123Iodine MIBG SPECT/CT for Tumor Imaging	59	(18)
Carl-Martin Kirsch
Ora Israel
Introduction	59	(1)
Radiolabeled MIBG	59	(1)
123I and 131I MIBG Scintigraphy	60	(7)
MIBG SPECT/CT	67	(6)
Conclusion	73	(1)
References	73	(4)
111Indium Octreotide SPECT/CT for Neuroendocrine Tumor Imaging	77	(16)
Stanley J. Goldsmith
Rosna M. Mirtcheva
Lale Kostakoglu
Introduction	77	(1)
Somatostatin and Somatostatin Receptors	77	(1)
111In-Octreotide	78	(1)
111In-Octreotide Planar and SPECT Scintigraphy	78	(4)
111In-Octreotide Co-Registration and SPECT/CT	82	(9)
Summary and Conclusions	91	(1)
References	91	(2)
Bone SPECT/CT in Oncology	93	(14)
Marius Stefan Horger
Susanne Martina Eschmann
Roland Bruno Bares
Introduction	93	(2)
Clinical Indications for Bone Scintigraphy, SPECT, and SPECT/CT	95	(1)
Bone Metastases: Incidence, Distribution, Clinical Features, and Imaging Characteristics	96	(1)
Bone Scintigraphy and SPECT/CT in Specific Malignant Tumors	96	(6)
Conclusion	102	(2)
References	104	(3)
67Gallium SPECT/CT in Imaging of Lymphoma	107	(14)
Rachel Bar-Shalom
Ora Israel
Introduction	107	(1)
Technical Aspects of Gallium SPECT/CT in Lymphoma	108	(2)
Clinical Aspects of Gallium SPECT/CT in Lymphoma	110	(7)
Conclusion and Future Prospects	117	(1)
References	117	(4)
Sentinel Node Scintigraphic Mapping Using SPECT/CT	121	(20)
Einat Even-Sapir
Introduction	121	(1)
The Clinical Impact of Sentinel Node Biopsy	121	(2)
Sentinel Node Identification	123	(2)
Interpretation of Lymphoscintigraphy	125	(2)
Lymphoscintigraphy with SPECT/CT in Patients with Melanoma, Breast Cancer, and Head and Neck Malignancy	127	(7)
References	134	(7)
SPECT/CT Imaging for Prostate Cancer	141	(16)
Scott C. Bartley
Naomi P. Alazraki
Stanley J. Goldsmith
Introduction	141	(1)
Prostate Specific Antigen	141	(1)
Clinical Features of Prostate Cancer	142	(1)
Imaging of Prostate Cancer	143	(1)
Imaging of Prostate Cancer Using Radiolabeled Monoclonal Antibody	143	(3)
Scintigraphic Imaging Protocols	146	(4)
SPECT/CT Imaging	150	(3)
111In Capromab Pendetide SPECT/CT in Therapy Planning	153	(1)
Conclusion	154	(1)
References	154	(3)
SPECT/CT for Dosimetry Calculations	157	(24)
Eric C. Frey
Introduction	157	(1)
Review of Dosimetry Concepts and Dose Estimation Methods	158	(2)
Conventional Methods for Estimating Cumulated Activity from Planar Images	160	(5)
Potential Improvements in Dose Estimation Using SPECT/CT Systems	165	(1)
Quantitative Planar Methods	165	(1)
Quantitative SPECT Methods	166	(6)
Quantitative SPECT Methods for Cumulated Activity Estimation	172	(1)
Clinical Application of SPECT/CT for Dosimetry	172	(4)
Summary	176	(2)
References	178	(3)
PART III: ADDITIONAL AND FUTURE APPLICATIONS OF SPECT/CT
SPECT/CT Attenuation Compensation in Nuclear Cardiology	181	(16)
Michael K. O'Connor
Introduction	181	(1)
Scatter Correction	182	(2)
Depth-Dependent Resolution Recovery	184	(1)
Attenuation Compensation	185	(2)
SPECT/CT	187	(4)
The Future of SPECT/CT in Attenuation Compensation	191	(1)
References	192	(5)
SPECT/CT in the Evaluation of Infection	197	(12)
Zohar Keidar
Ora Israel
Introduction	197	(2)
67Gallium Citrate	199	(1)
Radiolabeled Leukocytes	200	(3)
Labeled Antigranulocyte Antibodies	203	(2)
Labeled Human Nonspecific Immunuglobulin	205	(1)
Additional Radiolabeled Molecules for Infection Imaging	205	(1)
Conclusions	206	(1)
References	207	(2)
SPECT/CT Imaging of Small Animals	209	(32)
Bruce H. Hasegawa
Role of Small Animals in Biomedical Research	209	(2)
Small Animal SPECT Imaging	211	(7)
Small Animal CT Imaging	218	(2)
Implementation of Small Animal SPECT/CT Systems	220	(3)
Practical Issues Associated with Small Animal SPECT/CT Imaging	223	(2)
Radionuclide Quantification with Small Animal SPECT/CT	225	(1)
Applications of Small Animal SPECT and SPECT/CT Imaging	226	(4)
Future of Small Animal SPECT/CT Imaging	230	(3)
Concluding Remarks	233	(1)
References	234	(7)
Index	241