Hypothalamic Integration of Energy Metabolism

by Kalsbeek; Fliers; Hofman; Swaab; Van Someren; Buijs

• ISBN13: 9780444522610
• ISBN10: 0444522611
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-10-04
• Publisher: Elsevier Science

Summary

The prevalence of obesity in developed countries is fast becoming a health issue on par with infectious diseases and malnutrition. Research in this area has grown substantially and includes the neurochemical pathways of the hypothalamus and its role in regulating energy expenditures in the body. This volume in the Progress in Brain Research series examines the emerging role of the hypothalamus as a crucial link between the sensing of nutrients and the control of insulin sensitivity, glucose uptake, and glucose production, the integrative role of the hypothalamus in thyroid and bone metabolism, the interaction between circadian information and energy metabolism, and the important interplay between the immune system and energy metabolism. All contributors are recognized experts in their respective specialities Provides expanded coverage of hypothalamic mechanisms involved in energy metabolism Includes many outstanding full-colour illustrations Contains special sections on circadian rhythms, immune system, thyroid and bone metabolism

Table of Contents

List of Contributors	v
Preface	ix
Acknowledgements	xi
Section I. Hypothalamic Integration of Energy Metabolism
The human hypothalamus in metabolic and episodic disorders	3	(44)
D.F. Swaab
Synaptic plasticity mediating Leptin's effect on metabolism	47	(10)
T.L. Horvath
The hypothalamus, hormones and hunger: alterations in human obesity and illness	57	(18)
A.P. Goldstone
Glucocorticoids, chronic stress, and obesity	75	(32)
M.F. Dallman
N.C. Pecoraro
S.E. La Fleur
J.P. Warne
A.B. Ginsberg
S.F. Akana
K.C. Laugero
H. Houshyar
A.M. Strack
S. Bhatnagar
M.E. Bell
Design and synthesis of (ant)-agonists that alter appetite and adiposity	107	(12)
L.H.T. Van Der Ploeg
A. Kanatani
D. MacNeil
T.M. Fong
A. Strack
R. Nargund
X.-M. Guan
Monogenic human obesity syndromes	119	(10)
I. S. Farooqi
Section II. Hypothalamic Integration of Blood-borne Signals
The selfish brain: competition for energy resources	129	(12)
H.L. Fehm
W. Kern
A. Peters
Integration of metabolic stimuli in the hypothalamic arcuate nucleus	141	(14)
M. van den Top
D. Spanswick
Adipokines that link obesity and diabetes to the hypothalamus	155	(22)
R.S. Ahima
Y. Qi
N.S. Singhal
Section III. Hypothalamic Control of Bone and Thyroid Metabolism
The circadian modulation of Leptin-controlled bone formation	177	(12)
L. Fu
M.S. Patel
G. Karsenty
Hypothalamic thyroid hormone feedback in health and disease	189	(20)
E. Fliers
A. Alkemade
W.M. Wiersinga
D.F. Swaab
The TRH Neuron: a hypothalamic integrator of energy metabolism	209	(30)
R.M. Lechan
C. Fekete
Section IV. Rhythms, Sleep and Energy Metabolism
The seventeenth C.U. Ariens Kappers Lecture: an Introduction	239	(4)
M.A. Hofman
D.F. Swaab
Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms	243	(10)
C.B. Saper
Circadian timing in health and disease	253	(18)
E.S. Maywood
J. O'Neill
G.K.Y. Wong
A.B. Reddy
M.H. Hastings
Circadian time keeping: the daily ups and downs of genes, cells and organisms	271	(12)
U. Schibler
The hypothalamic clock and its control of glucose homeostasis	283	(26)
A. Kalsbeek
M. Ruiter
S.E. La Fleur
C. Cailotto
F. Kreier
R.M. Buijs
Mechanisms and functions of coupling between sleep and temperature rhythms	309	(16)
E.J.W. Van Someren
What can we learn from seasonal animals about the regulation of energy balance?	325	(16)
P.J. Morgan
A.W. Ross
J.G. Mercer
P. Barrett
Section V. Hypothalamic Integration of ``Sensory'' Information
Organization of circadian functions: interaction with the body	341	(20)
R.M. Buijs
F.A. Scheer
F. Kreier
C. Yi
N. Bos
V.D. Goncharuk
A. Kalsbeek
Hypoglycemia in diabetes: pathophysiological mechanisms and diurnal variation	361	(6)
P.E. Cryer
Hypothalamic integration of immune function and metabolism	367	(40)
A. Guijarro
A. Laviano
M.M. Meguid
Subject Index	407