Hypoxia and Consequences, Volume 1177

by Peers, Chris; Haddad, Gabriel G.; Chandel, Navdeep S.

• ISBN13: 9781573317733
• ISBN10: 157331773X
• Edition: 1st
• Format: Paperback
• Copyright: 2009-11-23
• Publisher: Wiley-Blackwell

Summary

International experts from academia, industry and government discuss the cellular mechanisms that underlie rapid and delayed responses to oxygen deprivation, known as hypoxia. This volume brings together researchers and clinicians from developmental and cellular biology, drug development, oncology, neurobiology and medicine to discuss 1) How hypoxia-inducible factors regulate development and physiology, 2) How cells sense changes in oxygen availability, and 3) How oxygen availability affects several pathologies like pulmonary hypertension, sleep apnea, cancer and neurodegeneration.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Chris Peers and Gabriel G. Haddad are the authors of Hypoxia and Consequences, Volume 1177, published by Wiley.

Table of Contents

Introduction to Hypoxia and Consequences: From Molecule to Malady

Transcriptional Responses to Hypoxia

Regulation of Vascularization by Hypoxia-Inducible Factor 1

FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins

From Polyps to People: A HIghly Familiar Response to Hypoxia

Maintaining Mammalian Iron and Oxygen Homeostasis: Sensors, Regulation, and Cross-Talk

Survival in Acute and Severe Low O₂ Environment: Use of a Genetic Model System

Mitochondria and Hypoxic Signaling: A New View

Pathophysiological Consequences of HIF Activation: HIF as a Modulator of Fibrosis

Mitochondrial Metabolism and Cancer

Oxygen Sensing

Molecular Imaging: Into In Vivo Interaction of HIF-1 and HIF-2 with ARNT

Oxygen-Sensitive Potassium Channels in Chemoreceptor Cell Physiology: Making a Virtue of Necessity

Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery

Hypoxia Selectively Inhibits KCNA5 Channels in Pulmonary Artery Smooth Muscle Cells

Enzyme-Linked Oxygen Sensing by Potassium Channels

Oxygen Sensing in the Carotid Body

Regulation of Oxygen Sensitivity in Adrenal Chromaffin Cells

Oxidative DNA Modifications in Hypoxic Signaling

The Neuronal Control of Hypoxic Ventilation: Erythropoietin and Sexual Dimorphism

Pathophysiological Responses to Hypoxia

Intermittent Hypoxia-Mediated Plasticity of Acute O2 Sensing Requires Altered Red-Ox Regulation by HIF-1 and HIF-2

Hypoxia and Neurodegeneration

The Role of NF-B in Hypoxia-Induced Gene Expression

Role of Hypoxia-Inducible Factors in Epigenetic Regulation via Histone Demethylases

An Essential Role of the HIF-1-c-Myc Axis in Malignant Progression

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