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Image-guided radiation treatment (IGRT) is rapidly becoming the standard in external-beam radiation therapy. Its advantages include greater precision, reduced likelihood of positioning errors, and online correction of motion errors. This volume provides a cutting-edge overview of the latest IGRT technology and systems, including an historical perspective, discussion of future directions, and insights from the firsthand experiences of the expert authors. Each chapter discusses the geometry of the imaging and treatment system, relevant imaging principles and algorithms, treatment principles, image fidelity (scatter, spatial, and contrast resolution), and clinical applications.