Immune Dysfunction and Immunotherapy in Heart Disease

by Watson, Ronald Ross; Larson, Douglas F.

• ISBN13: 9781405155687
• ISBN10: 140515568X
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-09-24
• Publisher: Wiley-Blackwell

Summary

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.The four parts of the book address: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs Immune Dysfunction Leading to Heart Disease: Induction by PathogensBoth researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Author Biography

Dr. Larson and Dr. Watson have worked together researching the role of immune and cytokine dysfunction in heart disease for 8 years. They have been and currently are funded to do such research by grants from the U.S. National Institute of Heart, Lung and Blood, the American Heart Foundation, companies and private foundations. Dr. Watson has edited 62 scientific books, including several dealing with heart disease and conditions such as aging and AIDS that promote immune dysfunction as well as heart disease. Dr. Larson directs the Center's organ perfusion program as well as its Master degree in pharmacology and toxicology for perfusion students.

____________________________________________________________________

Ronald Ross Watson Ph.D.

Professor Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245155, 1501 N. Campbell Avenue, Tucson, AZ 85749.

[phone], Fax [phone] [e-mail]

____________________________________________________________________

Douglas F. Larson Ph.D.

Professor Surgery and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell Avenue, Tucson, AZ 85749. [phone] [e-mail]

Table of Contents

Contributors	p. vii
Preface	p. xi
About the Editors	p. xiii
Immune dysfunction leading to heart disease: induction by physiological changes	p. 1
Immunosuppression by ultraviolet light-B radiation: a mediator of cardiac remodeling	p. 3
Immune mechanisms in pediatric cardiovascular disease	p. 6
Heart failure-role of autoimmunity	p. 17
Immune basis of hypertension in humans	p. 28
Immune dysregulation: potential mediator of metabolic syndrome-induced cardiac remodeling	p. 34
T helper 2 cell cytokines in remodeling of aortic wall	p. 39
Effects of TNF-[alpha] on cardiac function	p. 48
Immunosuppression in promotion of cardiac allograft vasculopathy	p. 57
Immunotherapy for left ventricular dysfunction after heart transplantation	p. 80
Immune dysfunction promoting CVD: induction by transplantation drugs	p. 95
Immunomodulating therapy in chronic heart failure	p. 97
Statins in atherosclerosis: role of immune regulation	p. 109
ACE inhibitors as immunomodulators: treatment of cardiovascular disease	p. 116
Treatment of heart failure by anticytokine therapies	p. 128
Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugs	p. 133
Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndrome	p. 135
Cytokines and T cell-mediated responses in autoimmune myocarditis	p. 152
Drugs of abuse: accentuation of immunomodulation of viral myocarditis	p. 157
Immune dysfunction leading to heart disease: induction by pathogens	p. 173
Osteopontin: the link between the immune system and cardiac remodeling	p. 175
Inflammatory immune activation in heart failure patients: therapeutic implications	p. 182
Role of innate immune dysregulation in diabetic heart failure	p. 186
Tolerance in heart transplantation: current and future role	p. 195
Neutralization of Th2 cytokines in therapy of cardiovascular pathology	p. 207
Anti-inflammatory immune therapy in heart disease	p. 217
Cholesterol, interleukin-6 inflammation, and atherosclerosis-role of statins, bisphosphonates, and plant polyphenols in atherosclerosis and other diseases of aging	p. 227
Autoimmune myocarditis: treatment with anti-T-cell antibodies	p. 256
Immunosuppressive therapy to counter cardiac allograft vasculopathy	p. 263
Role of oral pathogens in the pathogenesis of coronary heart disease	p. 271
Myocardial regenerative potential by stem cell transplant	p. 280
Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseases	p. 288
Index	p. 301
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