Immunology A Comprehensive Review

by Wise, Darla J.; Carter, G. R.

• ISBN13: 9780813815992
• ISBN10: 0813815991
• Edition: 8th
• Format: Paperback
• Copyright: 2002-06-24
• Publisher: Wiley-Blackwell

Summary

Immunology: A Concise Review offers the essential and basic ideas of immunology as a quick reference for students, practitioners, and veterinary technicians. Although concise, the book is comprehensive and a knowledge of its contents will assure the reader a relatively thorough understanding of what is frequently a difficult subject. The book covers all of the basics of immunology, including chapters on: the origin and function of hemopoietic and lymphopoietic cells; non-specific immunity; antigens; complement; cell receptors and cytokines associated with the immune response; specific immune responses; responses to bacteria, fungi, protozoa, helminths, and tumors. More advanced topics include: an examination of all four hypersensitivity reactions; autoimmunity; immune deficiency diseases; organ transplant and rejection; vaccination and immunization; and immunodiagnostic techniques. Additionally, the book offers end of chapter glossaries and a cumulative glossary as well as explanatory black and white illustrations.

Author Biography

Dr. Darla J. Wise, M.S. Ph.D., is an Assistant Professor of Biology at Concord College in Athens, WV, and is the Associate Editor of Proceedings of the West Virginia Academy of Science. Dr. Wise’s research interest lies in the area of host-pathogen relationships. She has authored articles in the areas of immune responses, characterization of enzymes associated with host-pathogen relationships, and DNA-based methods of disease diagnosis.

Gordon R. Carter, D.V.M., M.S., D.V.Sc., is a Professor Emeritus of the Department of Biomedical Sciences and Pathobiology at the Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University in Blacksburg. Professor Carter has published many scientific papers and is the senior author f more that a dozen textbooks.

Table of Contents

Preface	ix
Abbreviations and Greek Letters	xi
Introducing Immunology	3	(10)
Basic Concepts	3	(4)
Milestones in Immunology	7	(3)
Glossary	10	(3)
The Hemopoietic and Lymphopoietic Cells	13	(6)
The Hemopoietic System	13	(2)
The Lymphopoietic System	15	(2)
Lymphoid Organs	17	(1)
The Lymphatic System	17	(1)
Glossary	18	(1)
Natural Immunity and Resistance	19	(6)
Natural or Native Immunity	19	(1)
Physical and Chemical Barriers	19	(1)
Inflammation	20	(1)
Fever	21	(1)
Phagocytosis	22	(1)
Extracellular Killing	23	(1)
Interferons	23	(1)
Natural Killer (NK) Cells	23	(1)
Glossary	24	(1)
The Nature of Antigens	25	(6)
Haptens	26	(1)
B Lymphocytes	27	(2)
T Lymphocytes	29	(1)
Antigen Processing	29	(1)
Glossary	30	(1)
The Complement System	31	(6)
Cascade	31	(1)
Cytolysis	32	(1)
Inflammation	32	(1)
Opsonization and Immune Adherence	33	(1)
The Classical Pathway	33	(2)
The Alternative Pathway	35	(1)
Glossary	36	(1)
T Cell Receptors, Major Histocompatibility Complex, and Cytokines	37	(12)
T Cell Receptors	37	(3)
Major Histocompatibility Complex (MHC)	40	(5)
Cytokines	45	(2)
Glossary	47	(2)
The Humoral Immune Response	49	(12)
Structure and Assembly of Antibodies/Immunoglobulins	49	(3)
Isotype/Class Switching	52	(2)
The Clonal Selection Theory of Antibody Production	54	(2)
Antibody Response and Antigen-Antibody Interactions	56	(1)
Primary and Secondary Humoral Immune Responses	57	(2)
Glossary	59	(2)
The Cell-Mediated Immune Response	61	(8)
T Lymphocytes (T Cells)	61	(2)
Cell-Mediated Cytotoxicity	63	(3)
The Role of Macrophages	66	(1)
Immunopathology	67	(1)
Glossary	67	(2)
The Immune System in Action	69	(20)
Immunity to Bacteria	69	(3)
Immunity to Viruses	72	(4)
Immunity to Fungi	76	(2)
Immunity to Protozoa and Helminths	78	(3)
Immunity to Tumors	81	(4)
Tumor Immunotherapy	85	(2)
Glossary	87	(2)
Hypersensitivity Reactions Part I: Allergy and Anaphylaxis	89	(12)
Type 1 Immediate or Anaphylactic Hypersensitivity	89	(1)
Allergy and Anaphylaxis	89	(11)
Glossary	100	(1)
Hypersensitivity Reactions Part II: Cytotoxic/Cytologic, Immune Complex, and Delayed-Type	101	(12)
Cytotoxic/Cytolytic Reactions	101	(3)
Immune Complex Disease	104	(4)
Type IV Delayed-Type Hypersensitivity	108	(3)
Glossary	111	(2)
Autoimmunity	113	(6)
Development	113	(1)
Role of Heredity	114	(1)
Environment	115	(1)
Examples of Autoimmune Diseases	116	(2)
Diagnosis	118	(1)
Treatment	118	(1)
Immunodeficiencies	119	(4)
Primary Immunodeficiencies	119	(2)
Secondary Deficiencies	121	(1)
Glossary	122	(1)
Transplantation and Graft Rejection	123	(6)
Rejection	123	(6)
Vaccination and Immunization	129	(8)
Natural and Artificial Immunization	129	(1)
Active Immunization	130	(1)
Vaccines	131	(1)
Current and New Vaccine Development	132	(3)
Passive Immunization	135	(2)
Immunodiagnostic Techniques	137	(14)
Antibody Detection and Measurement	137	(1)
Procedures	138	(11)
Glossary	149	(2)
Human Immunodeficiency Virus (HIV) Infection and Acquired Immune Deficiency Syndrome (AIDS)	151	(12)
General	151	(2)
The Virus and Pathogenesis	153	(4)
Immunology	157	(1)
Vaccination	158	(1)
Diagnosis	159	(1)
Treatment	160	(1)
Immune Restoration	161	(1)
Glossary	161	(2)
Cumulative Glossary	163	(10)
Index	173